Results 71 to 80 of about 356,980 (295)

Robust Tests for Treatment Effect in Survival Analysis under Covariate-Adaptive Randomization

open access: yes, 2019
Covariate-adaptive randomization is popular in clinical trials with sequentially arrived patients for balancing treatment assignments across prognostic factors which may have influence on the response.
Shao, Jun, Ye, Ting
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Effects of different building blocks designs on the statistical characteristics of Automated Zone-design Tool output areas

open access: yesSouth African Journal of Geomatics, 2017
Prior to any census, the country usually gets demarcated into small geographic units called census enumeration areas, districts or blocks. In most countries, these small geographic units are also used for census dissemination. In cases where they are not used for census release, they are normally used as building blocks for developing output areas or ...
Mokhele, T, Mutanga, O, Ahmed, F
openaire   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Compressive Sensing with Prior Support Quality Information and Application to Massive MIMO Channel Estimation with Temporal Correlation

open access: yes, 2015
In this paper, we consider the problem of compressive sensing (CS) recovery with a prior support and the prior support quality information available. Different from classical works which exploit prior support blindly, we shall propose novel CS recovery ...
Lau, Vincent K. N., Rao, Xiongbin
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

PROTOCOL: The effectiveness of abstinence‐based and harm reduction‐based interventions in reducing problematic substance use in adults who are experiencing severe and multiple disadvantage homelessness: A systematic review and meta‐analysis

open access: yesCampbell Systematic Reviews, 2022
Background Homelessness is a major social and public health concern. It is a traumatic experience, and can have a devastating effect on those experiencing it.
Chris O'Leary   +5 more
doaj   +1 more source

A general theory of minimum aberration and its applications

open access: yes, 2005
Minimum aberration is an increasingly popular criterion for comparing and assessing fractional factorial designs, and few would question its importance and usefulness nowadays.
Cheng, Ching-Shui, Tang, Boxin
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Identifying the best FDA-endorsed healthy label designs through best-worst scaling experiment

open access: yesPublic Health Nutrition
Objective: This study aims to assess consumer preferences for fifteen proposed front-of-package ‘Healthy’ label candidates under the Food and Drug Administration’s (FDA) of the US updated guidelines for the ‘Healthy’ label.
Jianhui Liu   +3 more
doaj   +1 more source

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