Results 71 to 80 of about 225,797 (277)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
From Entropic Dynamics to Quantum Theory
, 2010 Non-relativistic quantum theory is derived from information codified into an appropriate statistical model. The basic assumption is that there is an irreducible uncertainty in the location of particles: positions constitute a configuration space and the ...
Ariel Caticha +2 more
core +1 more source
Laplacian operator on statistical manifold
Information Geometry, 2022 In this paper, we define a Laplacian operator on a statistical manifold, called the vector Laplacian. This vector Laplacian incorporates information from the Amari-Chentsov tensor. We derive a formula for the vector Laplacian. We also give two applications using the heat kernel associated with the vector Laplacian.
Ruichao Jiang +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Information geometric methods for complexity
, 2018 Research on the use of information geometry (IG) in modern physics has witnessed significant advances recently. In this review article, we report on the utilization of IG methods to define measures of complexity in both classical and, whenever available,
Cafaro, C., Felice, D., Mancini, S.
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Solution manifold and its statistical applications
Electronic Journal of Statistics, 2022 Accepted to the Electronic Journal of Statistics.
openaire +3 more sources
Kähler-Norden structures on statistical manifolds
Filomat, 2022 In this paper, we construct K?hler-Norden statistical structures on pseudo-Riemannian manifolds equipped with a torsion-free linear connection and an almost complex structure. Also, we present some examples and study curvature properties for these structures by using Tachibana operator. Finally, we consider a Norden statistical manifold and
Nourmohammadifar, Leila +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source