Results 101 to 110 of about 5,300,854 (366)

Edwards Statistical Mechanics for Jammed Granular Matter [PDF]

open access: yes, 2016
In 1989, Sir Sam Edwards made the visionary proposition to treat jammed granular materials using a volume ensemble of equiprobable jammed states in analogy to thermal equilibrium statistical mechanics, despite their inherent athermal features. Since then,
A. Baule   +3 more
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Relativistic Statistical Mechanics vs. Relativistic Thermodynamics

open access: yesEntropy, 2011
Based on a covariant theory of equilibrium Thermodynamics, a Statistical Relativistic Mechanics is developed for the non-interacting case. Relativistic Thermodynamics and Jüttner Relativistic Distribution Function in a moving frame are obtained by using ...
Benjamín López-Carrera   +1 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Statistical mechanics of anharmonic lattices

open access: yes, 2003
This paper is a review on the statistical mechanics of anharmonic oscillators coupled to heat reservoirs. We discuss stationary states (existence and ergodic properties) and entropy production (positivity, Green-Kubo formulas and the Gallavotti-Cohen ...
Dedicated Lawrence   +2 more
core   +2 more sources

Thermodynamically consistent coarse graining of biocatalysts beyond Michaelis–Menten

open access: yesNew Journal of Physics, 2018
Starting from the detailed catalytic mechanism of a biocatalyst we provide a coarse-graining procedure which, by construction, is thermodynamically consistent.
Artur Wachtel   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

STATISTICAL MECHANICS OF ANYONS

open access: yesNuclear Physics B, 1985
We study the statistical mechanics of a two-dimensional gas of free anyons-particles which interpolate between Bose-Einstein and Fermi-Dirac character. Thermodynamic quantities are discussed in the low-density regime. In particular, the second virial coefficient is evaluated by two different methods and is found to exhibit a simple, periodic, but ...
Daniel P. Arovas   +3 more
openaire   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

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