Results 121 to 130 of about 3,597,417 (263)

CoRegNet: unraveling gene co-regulation networks from public RNA-Seq repositories using a beta-binomial statistical model. [PDF]

Brief Bioinform, 2023
Wang J, Wan YW, Al-Ouran R, Huang M, Liu Z.   +4 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Statistical Model to Estimate the Potential Risk of Work-Related Stroke among Office Workers: A Methodological Description Article. [PDF]

Iran J Public Health
Farghadan M, Almutairi NS, Shariat A, Anastasio AT.   +3 more
europepmc   +1 more source

Statistical model of trajectories of reduced mobility in older people with locomotive disorders: a prospective cohort study with group-based trajectory model. [PDF]

BMC Geriatr, 2023
Iwaya T, Tanabe H, Ohkuma Y, Ito A, Hayashi K, Ideno Y, Nagai K, Akai M.   +7 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Statistical Model of Ocular Wavefronts With Accommodation. [PDF]

Invest Ophthalmol Vis Sci
Mechó-García M, Arcas-Carbonell M, Orduna-Hospital E, Sánchez-Cano A, López-Gil N, Macedo-de-Araújo RJ, Faria-Ribeiro M, Fernandes P, González-Méijome JM, Rozema J.   +9 more
europepmc   +1 more source

Data analysis for COVID-19 deaths using a novel statistical model: Simulation and fuzzy application. [PDF]

PLoS One, 2023
El-Sherpieny EA, Almetwally EM, Muse AH, Hussam E.   +3 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

scDETECT: a novel statistical model accounting for cell type correlation in single-cell RNA-seq differential expression analysis. [PDF]

Brief Bioinform
Xu Y, Zhang W, Wu H.
europepmc   +1 more source

Validation of depression determinants in caregivers of dementia patients with machine learning algorithms and statistical model. [PDF]

Front Med (Lausanne), 2023
Cho K, Choi J, Han S.
europepmc   +1 more source