Results 111 to 120 of about 775,359 (318)
Flexible Low-Rank Statistical Modeling with Missing Data and Side Information [PDF]
, 2018 We explore a general statistical framework for low-rank modeling of matrix-valued data, based on convex optimization with a generalized nuclear norm penalty.
Fithian, William +3 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Statistical Modeling of Spatial Extremes
Statistical Science, 2012 The areal modeling of the extremes of a natural process such as rainfall or temperature is important in environmental statistics; for example, understanding extreme areal rainfall is crucial in flood protection. This article reviews recent progress in the statistical modeling of spatial extremes, starting with sketches of the necessary elements of ...
A. C. Davison +2 more
openaire +6 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Improving the effectiveness of language modeling approaches to information retrieval: bridging the theory-effectiveness gap [PDF]
, 2012 "The recent decade has witnessed an explosive growth of online information with the birth of Web. Search engines such as Google and Bing are by far the most powerful tools that help users find relevant information from large amounts of Web texts and have
Lv,Yuanhua
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Who lies? A large-scale reanalysis linking basic personality traits to unethical decision making
Judgment and Decision Making, 2018 Previous research has established that higher levels of trait Honesty-Humility (HH) are associated with less dishonest behavior in cheating paradigms. However, only imprecise effect size estimates of this HH-cheating link are available.
Daniel W. Heck +3 more
doaj +1 more source
Developer-Friendly and Computationally Efficient Predictive Modeling without Information Leakage : The emil Package for R [PDF]
, 2018 Data driven machine learning for predictive modeling problems (classification, regression, or survival analysis) typically involves a number of steps beginning with data preprocessing and ending with performance evaluation.
Gustafsson, Mats G. +3 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source