Results 171 to 180 of about 5,852,793 (269)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Disparity between statistical significance and clinical importance in published randomised controlled trials: a methodological study. [PDF]

BMJ Open
Esterhuizen TM, Mbuagbaw L, Rehman N, Yanwou N, Swaby DJ, Kittle E, Licht JC, Thabane L.   +7 more
europepmc   +1 more source

Statistical Significance Testing for Mixed Priors: A Combined Bayesian and Frequentist Analysis. [PDF]

Entropy (Basel), 2022
Robnik J, Seljak U.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Data interpretation and statistical significance

Indian Journal of Dental Research, 2019
S M Balaji
doaj   +1 more source

Clinical significance versus statistical significance: Does it matter in clinical practice? [PDF]

Indian J Anaesth
Mohanty CR, Barik AK, David GAJ, Radhakrishnan RV.   +3 more
europepmc   +1 more source

Is it time to stop using statistical significance? [PDF]

Aust Prescr, 2021
Frank O, Tam CM, Rhee J.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

ProOvErlap: Assessing feature proximity/overlap and testing statistical significance from genomic intervals. [PDF]

J Biol Chem
Gualandi N, Bertozzo A, Brancolini C.
europepmc   +1 more source

Statistical significance and its critics: practicing damaging science, or damaging scientific practice? [PDF]

Synthese, 2022
Mayo DG, Hand D.
europepmc   +1 more source