Results 31 to 40 of about 6,116,423 (300)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Detecting an Unknown Abrupt Change in the Band Center of the Fast-Fluctuating Gaussian Random Process

Measurement Science Review, 2020
The generalized maximum likelihood algorithm is introduced for detecting the abrupt change in the band center of a fast-fluctuating Gaussian random process with the uniform spectral density.
Chernoyarov Oleg, Demina Tatiana, Kabanov Yuri, Makarov Alexander   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An age-structured mathematical model of tetanus epidemiology, immunity, and vaccination across the life course

Frontiers in Public Health
IntroductionTetanus remains a significant public health concern despite substantial reductions in incidence and mortality following the widespread introduction of tetanus-toxoid-containing vaccines (TTCVs).
Rachel A. Hounsell, Rachel A. Hounsell, Jared Norman, Sheetal P. Silal, Sheetal P. Silal   +4 more
doaj   +1 more source

Statistical analysis of simulation output [PDF]

Proceedings of the 29th conference on Winter simulation - WSC '97, 1997
This paper describe , in general terms, methods to help design the run for simulation models and interpreting their out ut. Statistical methods are described for several different purposes, and related problems like comparison, variance reduction, sensitivity estimation, etamodeling, and optimization are mentioned.
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Archetype-based stratification to inform sub-national tailoring of malaria interventions in Zambia

Malaria Journal
Introduction Although Zambia does not rank among the highest contributors to global malaria cases, in 2023, it had approximately eleven million cases. Furthermore, Zambia’s malaria incidence distribution is spatially heterogeneous at fine scales such as ...
Chilochibi Chiziba, Japhet Chiwaula, Busiku Hamainza, Sampa Chitambala-Otiono, Sheetal Silal   +4 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

ARIMA Markov Model and Its Application of China’s Total Energy Consumption

Energies
We propose an auto regressive integrated moving average Markov model (ARIMAMKM) for predicting annual energy consumption in China and enhancing the accuracy of energy consumption forecasts.
Chingfei Luo, Chenzi Liu, Chen Huang, Meilan Qiu, Dewang Li   +4 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source