Results 51 to 60 of about 64,777 (300)

Super-refractory status epilepticus and ischemic stroke: A clinical case report

Неврология, нейропсихиатрия, психосоматика, 2017
Generalized convulsive status epilepticus (GCSE) is the most dangerous type of status epilepticus. The paper describes a clinical case of a 33-year-old female patient admitted to an intensive care unit for diagnosed ischemic stroke in the posterior ...
A. S. Kotov, M. A. Litvinenko, E. A. Sandu, M. A. Alakova, E. K. Sorokina   +4 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus

Neurobiology of Disease, 2014
Anti-inflammatory therapies are the current most plausible drug candidates for anti-epileptogenesis and neuroprotection following prolonged seizures.
B.A. Duffy, K.P. Chun, D. Ma, M.F. Lythgoe, R.C. Scott   +4 more
doaj   +1 more source

Evaluating the effectiveness of the Emergency Neurological Life Support educational framework in low-income countries. [PDF]

, 2018
BackgroundThe Emergency Neurological Life Support (ENLS) is an educational initiative designed to improve the acute management of neurological injuries. However, the applicability of the course in low-income countries in unknown.
Acharya, Subhash, Bellini, Antonio, Goffi, Alberto, Hemphill, J Claude, McCredie, Victoria A, Shrestha, Gentle S, Singh, Jeffrey M   +6 more
core   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Interleucina-1ß, crisis convulsivas y muerte neuronal

Revista Peruana de Medicina Experimental y Salud Pública, 2013
La epilepsia es un trastorno neurológico que afecta aproximadamente al 1% de la población mundial. Estudios realizados en humanos y animales de experimentación sugieren que mediadores de inflamación, como las citocinas, participan en la fisiopatología de
Jesús S Medel-Matus, Libia X Cortijo-Palacios, Dulce M Álvarez-Croda, Joel Martínez-Quiroz, María L López-Meraz   +4 more
doaj  

Rapamycin attenuates acute seizure-induced astrocyte injury in mice in vivo [PDF]

, 2017
Astrocytes have been implicated in epileptogenesis and seizure-induced brain injury. Pathological studies reveal a variety of structural abnormalities in astrocytes, such as vacuolization and astrogliosis.
Guo, Dongjun, Wong, Michael, Zou, Jia
core   +2 more sources

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Time to treatment in pediatric patients with repeated episodes of status epilepticus

BMC Neurology
Objective To compare pediatric patients who presented with repeated status epilepticus episodes to patients with a single episode of status epilepticus and identify distinguishing clinical factors.
Jennifer V. Gettings, Iván Sánchez Fernández, Anne Anderson, J. Nicholas Brenton, Afra Can, Justice Clark, Raquel Farias Moeller, Howard P. Goodkin, Yi-Chen Lai, Mohamad A. Mikati, Lindsey A. Morgan, Edward Novotny, Adam P. Ostendorf, Juan Piantino, James J. Riviello, Kumar Sannagowdara, Robert C. Tasker, Dmitry Tchapyjnikov, Mark S. Wainwright, Angus Wilfong, Korwyn Williams, Bo Zhang, Tobias Loddenkemper, Marina Gaínza-Lein, on behalf of Pediatric Status Epilepticus Research Group (pSERG)   +24 more
doaj   +1 more source

Status epilepticus-induced changes in the subcellular distribution and activity of calcineurin in rat forebrain

Neurobiology of Disease, 2003
This study was performed to determine the effect of prolonged status epilepticus on the activity and subcellular location of a neuronally enriched, calcium-regulated enzyme, calcineurin. Brain fractions isolated from control animals and rats subjected to
Jonathan E Kurz, Annu Rana, J.Travis Parsons, Severn B Churn   +3 more
doaj   +1 more source