Results 51 to 60 of about 32,338 (260)

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

Gephyrin Neurological Autoimmunity

Annals of Neurology, EarlyView.
Gephyrin is a postsynaptic scaffold protein essential for inhibitory neurotransmission. Gephyrin‐immunoglobulin G (IgG) was reported, decades ago, in a single case of paraneoplastic stiff‐person‐like syndrome, but its broader clinical relevance remains unknown.
Maria Chiara Pantuliano, Friederike A. Arlt, Naomi Arenson, Irena Dujmovic Basuroski, Divyanshu Dubey, Connie E. Lesnick, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael A. Lane, Andrew McKeon   +10 more
wiley   +1 more source

Gut–Brain Axis Modulation by Short‐Chain Fatty Acids Exerts Disease‐Modifying Effects in a Murine Model of Drug‐Resistant Epilepsy

Annals of Neurology, EarlyView.
Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera, Rossella Di Sapia, Greta Volpedo, Sneha Anand, Eray Sahin, Pasquale Baldassarre, Francesca Buffelli, Andrea Petretto, Chiara Lavarello, James D. Mills, Gabriele Cattaneo, Ilaria Craparotta, Eleonora Aronica, Antonella Riva, Pasquale Striano, Annamaria Vezzani, Teresa Ravizza   +16 more
wiley   +1 more source

Updates in Refractory Status Epilepticus

Critical Care Research and Practice, 2018
Refractory status epilepticus is defined as persistent seizures despite appropriate use of two intravenous medications, one of which is a benzodiazepine. It can be seen in up to 40% of cases of status epilepticus with an acute symptomatic etiology as the
Rohit Marawar, Maysaa Basha, Advait Mahulikar, Aaron Desai, Kushak Suchdev, Aashit Shah   +5 more
doaj   +1 more source

Management Guidelines for the Treatment of Pediatric Brain Tumor–Associated Seizure: A Modified Delphi Consensus Report

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Seizures represent a significant source of morbidity for children with brain tumors. The objective of our study was to establish consensus guidelines for managing children with tumor‐related epilepsy. Methods The study team assembled a panel of 18 child neurologists specializing in neurological complications of brain tumors including
Stephanie N. Brosius, Jacky Ta, Juliane Gust, Fatema Malbari, Mai T. Dang   +4 more
wiley   +1 more source

Management of super refractory status epilepticus with isoflurane and hypothermia

Frontiers in Neurology, 2015
Super-refractory status epilepticus is status epilepticus that continues beyond 24 hours and includes those cases in which epilepsy is recurrent upon reduction or withdrawal of treatment.
Charles Patrick Gilman
doaj   +1 more source

Vagus nerve stimulation in super-refractory status epilepticus following hypoxic brain injury: a case report and review of the literature

Interdisciplinary Neurosurgery
Background: Status epilepticus (SE) is a life-threatening neurological condition that can be resistant to pharmacological treatments, particularly when triggered by severe brain insults such as asphyxia.
Farzan Fahim, Mahdi Mehmandoost, Faezeh Mousavinia, Amirmohammad Bahri, Negin Safari Dehnavi, Almirabbas Rouholamini, Omidreza Nikbakhtamirabad, Parisa Nikbakhtamirabad, Diba Akbarzadeh, Sayeh Oveisi, Yousef Moghadasi, Alireza Zali, Bijan Herfedoustbiazar   +12 more
doaj   +1 more source

A Case of Autoimmune Encephalitis with Refractory Status Epilepticus

Archives of Epilepsy, 2019
Refractory status epilepticus is usually caused by a severe brain injury and has a high rate of mortality and morbidity despite the infusion of antiepileptic drugs and anesthetic agents.
Merve Melodi ÇAKAR, Aslıhan AKŞAR, Meliha AKPINAR, Elif MERCAN, Sezgin KEHAYA, Babürhan GÜLDİKEN   +5 more
doaj   +1 more source

P2X receptors as targets for the treatment of status epilepticus

Frontiers in Cellular Neuroscience, 2013
Prolonged seizures are amongst the most common neurological emergencies. Status epilepticus is a state of continuous seizures that is life-threatening and prompt termination of status epilepticus is critical to protect the brain from permanent damage ...
David C Henshall, David C Henshall, Miguel eDiaz-Hernandez, Miguel eDiaz-Hernandez, M. Teresa eMiras-Portugal, M. Teresa eMiras-Portugal, Tobias eEngel, Tobias eEngel   +7 more
doaj   +1 more source

“The Most Difficult Conversations We Have”: Resident Experiences With Pediatric Neuroprognostication

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Pediatric neuroprognostication is often complicated by uncertainty and embedded in high‐stakes medical decisions. For child neurology residents, participation in neuroprognostication can represent key learning experiences but also comes with emotional and ethical challenges, which poses a risk of moral distress.
Grant L. Lin, Beatrice D. White, Shelby D. Burk, Jessica A. Moriarty, David B. Mauser, Claire E. Wakefield, Courtney J. Wusthoff, Justin N. Baker   +7 more
wiley   +1 more source