Results 191 to 200 of about 25,871 (229)
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Synthesis of Staurosporine Aglycon
1997Abstract Discussion Points What is the mechanism of step b? Propose a mechanism for the transformation covered in step f. Simply refluxing compound 7 under an inert atmosphere in bromobenzene gave a product 10 in high yield. In the proton NMR spectrum of this product there were the following signals integrating for single protons; o 3.28
C J Moody +3 more
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Staurosporine-induced neurite outgrowth in PC12h cells
Experimental Cell Research, 1989Treatment of PC12h cells with staurosporine (100 nM), a potent inhibitor of protein kinases, promoted rapid outgrowth of neurites. The mechanism of neurite formation elicited by staurosporine is different from that elicited by nerve growth factor or by dibutyryl cyclic AMP, based on the independence from transcription or from activation of cyclic AMP ...
S, Hashimoto, A, Hagino
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Stabilization of blood platelet microtubular system by staurosporine
Life Sciences, 1989The stimulative effects of phorbol myristate acetate (PMA) on rabbit platelet shape change and platelet adhesion were completely inhibited by staurosporine (STS)-pretreatment. When the platelets were observed by whole mount immuno transmission electron microscopy (TEM), STS was found to stabilize platelet microtubular cytoskeleton.
N, Ishihara, M, Iwama, B, Kobayashi
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Effects of Staurosporine on Transcription by Vesicular Stomatitis Virus
Virology, 1993The protein kinase inhibitor staurosporine has been found to inhibit vesicular stomatitis virus transcription in infected BHK cells. Both primary and secondary transcription were virtually abolished by 10 microM staurosporine. In contrast, transcription by purified virions, or by nucleocapsids isolated from them, was unaffected by staurosporine ...
K D, Rigaut, Y, Gao, J, Lenard
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Mechanism of staurosporine-induced apoptosis in murine hepatocytes
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2002Staurosporine (STS) induces apoptosis in various cell lines. We report in this study that primary cultured mouse hepatocytes are less sensitive to STS compared with Jurkat cells and Huh-7 cells. In contrast to the cell lines, no apparent release of cytochrome c or loss of mitochondrial transmembrane potential was detected in primary hepatocytes ...
Guoping, Feng, Neil, Kaplowitz
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Staurosporine advances interblastomeric flattening of the mouse embryo
Zygote, 1993Staurosporine, an inhibitor of protein kinase activity, causes premature intercellular flattening of blastomeres but does not induce their premature polarisation. The flattening induced is calcium dependent, is reversed transiently at mitosis and requires the continuing presence of the drug.
D M, O'Sullivan +2 more
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Staurosporine Inhibits Invasion of Erythrocytes by Malarial Merozoites
Experimental Parasitology, 1994Staurosporine, a protein kinase inhibitor, inhibits the invasion of rhesus by Plasmodium knowlesi merozoites with an IC50 of 250 nM. The drug exerts its effects primarily on the merozoite, with little or no effect on the erythrocyte. Okadaic acid, an inhibitor of protein phosphatases, can partially abrogate the inhibitory effects of staurosporine ...
G E, Ward +3 more
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Staurosporine‐induced morphological changes in the rat osteoblasts.
Cell Biology International, 1993AbstractTreatment of cultured rat osteoblasts with staurosporine caused a rapid outgrowth of long slender cellular processes and the formation of stellate cells. The number of stellate cells increased with higher concentrations of and longer incubation with staurosporine.
R S, Yang +4 more
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Cell cycle synchronizing properties of staurosporine
Methods in Cell Science, 1996Staurosporine (SSP) is a microbial alkaloid isolated from cultures of Streptomyces. For its ability to specifically inhibit protein kinase C and other serine/threonine and tyrosine protein kinases, SSP has been utilized recently to synchronize cells in G1 and/or G2 phases of the cell cycle.
BRUNO, SILVIA +2 more
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Natural Staurosporine Derivatives with Fluorescence for Cancer Theranostics
ChemMedChemIn recent years, developing effective theranostic agents for precise cancer treatment has been one of the most prevalent strategies. Herein, three staurosporine derivatives, MCY‐STS, ECY‐STS, and ICY‐STS, synthesized through minor modifications of natural staurosporine, are reported. These derivatives not only exhibit attractive fluorescence properties,
Kualiang Li +10 more
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