Results 191 to 200 of about 25,920 (226)
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Effects of Staurosporine on Transcription by Vesicular Stomatitis Virus
Virology, 1993The protein kinase inhibitor staurosporine has been found to inhibit vesicular stomatitis virus transcription in infected BHK cells. Both primary and secondary transcription were virtually abolished by 10 microM staurosporine. In contrast, transcription by purified virions, or by nucleocapsids isolated from them, was unaffected by staurosporine ...
K D, Rigaut, Y, Gao, J, Lenard
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Staurosporine advances interblastomeric flattening of the mouse embryo
Zygote, 1993Staurosporine, an inhibitor of protein kinase activity, causes premature intercellular flattening of blastomeres but does not induce their premature polarisation. The flattening induced is calcium dependent, is reversed transiently at mitosis and requires the continuing presence of the drug.
D M, O'Sullivan +2 more
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Staurosporine Inhibits Invasion of Erythrocytes by Malarial Merozoites
Experimental Parasitology, 1994Staurosporine, a protein kinase inhibitor, inhibits the invasion of rhesus by Plasmodium knowlesi merozoites with an IC50 of 250 nM. The drug exerts its effects primarily on the merozoite, with little or no effect on the erythrocyte. Okadaic acid, an inhibitor of protein phosphatases, can partially abrogate the inhibitory effects of staurosporine ...
G E, Ward +3 more
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Mechanism of staurosporine-induced apoptosis in murine hepatocytes
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2002Staurosporine (STS) induces apoptosis in various cell lines. We report in this study that primary cultured mouse hepatocytes are less sensitive to STS compared with Jurkat cells and Huh-7 cells. In contrast to the cell lines, no apparent release of cytochrome c or loss of mitochondrial transmembrane potential was detected in primary hepatocytes ...
Guoping, Feng, Neil, Kaplowitz
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Staurosporine‐induced morphological changes in the rat osteoblasts.
Cell Biology International, 1993AbstractTreatment of cultured rat osteoblasts with staurosporine caused a rapid outgrowth of long slender cellular processes and the formation of stellate cells. The number of stellate cells increased with higher concentrations of and longer incubation with staurosporine.
R S, Yang +4 more
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Cell cycle synchronizing properties of staurosporine
Methods in Cell Science, 1996Staurosporine (SSP) is a microbial alkaloid isolated from cultures of Streptomyces. For its ability to specifically inhibit protein kinase C and other serine/threonine and tyrosine protein kinases, SSP has been utilized recently to synchronize cells in G1 and/or G2 phases of the cell cycle.
BRUNO, SILVIA +2 more
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Natural Staurosporine Derivatives with Fluorescence for Cancer Theranostics
ChemMedChemIn recent years, developing effective theranostic agents for precise cancer treatment has been one of the most prevalent strategies. Herein, three staurosporine derivatives, MCY‐STS, ECY‐STS, and ICY‐STS, synthesized through minor modifications of natural staurosporine, are reported. These derivatives not only exhibit attractive fluorescence properties,
Kualiang Li +10 more
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First Total Synthesis of Staurosporine and ent-Staurosporine
Journal of the American Chemical Society, 1995J. T. Link +2 more
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Staurosporine fermentation process.
1991A fermentation process for preparing staurosporine, a known antibiotic, employing a heretofore unknown microorganism is described, said micoorganism being classified as a novel strain of Streptomyces hygroscopicus and being herein designated Streptomyces hygroscopicus strain C39280-450-9 (ATCC 53730).
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