Results 171 to 180 of about 25,871 (229)

Molecular Subtyping and Prognostic Prediction in Pancreatic Cancer Based on Mitophagy-Related Genes. [PDF]

Int J Med Sci
Cai Y, Yue T, Ma Y, Liu G, Zhang J, Rong L.   +5 more
europepmc   +1 more source

Identification of MBT3T as a new effective therapeutic option in imatinib-resistant gastrointestinal stromal tumors (GISTs). [PDF]

J Exp Clin Cancer Res
Ravegnini G, Esposito D, Gorini F, Marforio TD, Coschina E, Benuzzi E, Simone A, Samaha A, Di Vito A, Rossi M, Hrelia P, Locatelli A, Calvaresi M, Facchinello N, Morigi R, Angelini S.   +15 more
europepmc   +1 more source

Discovery of Novel Piperidinyl-Based Benzoxazole Derivatives as Anticancer Agents Targeting VEGFR-2 and c-Met Kinases. [PDF]

Pharmaceuticals (Basel)
Eldehna WM, Elsayed ZM, Elnagar MR, El-Said AH, Majrashi TA, Negmeldin AT, Saleh AM, Elrayess R, Elnahriry KA, Chen ZL, Elagawany M, Tawfik HO.   +11 more
europepmc   +1 more source

In vitro adventitious root culture of Withania somnifera L.: a strategy for enhanced secondary metabolite production with therapeutic antioxidant and anti-inflammatory potential. [PDF]

Sci Rep
Mohammed DM, Abdelazeez WMA, Suliman AA, Sallam ARM, Sief-Eldein AGM, Aboueldis GR.   +5 more
europepmc   +1 more source

Thapsigargin triggers a non-apoptotic, caspase-independent programmed cell death in basophilic leukaemia cells. [PDF]

Cell Death Discov
Steiner P, Melek K, Andosch A, Wiesbauer L, Madlmayr A, Duggan M, Kerschbaum HH, Zierler S.   +7 more
europepmc   +1 more source

Inhibition of GPX4 induces the death of p53-mutant triple-negative breast cancer cells. [PDF]

Breast Cancer Res Treat
Tahaney WM, Lanier A, Qian J, Moyer CL, Nguyen N, Ma Y, Hill J, Powell RT, Stephan CC, Davies PJA, Mazumdar A, Brown PH.   +11 more
europepmc   +1 more source

Staurosporine Analogs Via C–H Borylation

ACS Medicinal Chemistry Letters, 2020
Staurosporine is among the most potent naturally occurring kinase inhibitors isolated to date and has served as a lead compound for numerous drug development efforts in several therapeutic areas. Herein we report that C-H borylation chemistry provides access to analogs of staurosporine that were previously inaccessible to medicinal chemists who, in the
Keighley N Reisenauer, Joseph H Taube, John L Wood   +2 more
exaly   +4 more sources

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Inhibition of aldosterone biosynthesis by staurosporine

Biological Chemistry, 2005
AbstractStaurosporine (STS) is a very potent broad-range kinase inhibitor, and its antiproliferative properties made it a lead compound for protein kinase C (PKC) inhibitors with therapeutic potential. Because STS also causes hypotension, we investigated in this study whether it directly interferes with the terminal steps of aldosterone biosynthesis ...
Matthias, Bureik, Alexander, Mion, Christopher J, Kenyon, Rita, Bernhardt   +3 more
openaire   +2 more sources

Molecular mechanism of staurosporine-induced apoptosis in osteoblasts

Pharmacological Research, 2000
Staurosporine, a microbial alkaloid, is a strong inhibitor of protein kinases. We induced apoptosis in murine osteoblast MC3T3E-1 cells by exposure to the staurosporine. Staurosporine transiently increased the phosphotransferase activity of c-Jun N-terminal kinase-1 (JNK1), which in turn may activate the transcriptional activity of activating protein-1
Han-Jung Chae, Soo-Wan Chae, Hyung-Ryong Kim   +2 more
exaly   +3 more sources

ChemInform Abstract: First Total Synthesis of Staurosporine and ent‐Staurosporine.

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
J. T. LINK, S. RAGHAVAN, S. J. DANISHEFSKY   +2 more
openaire   +1 more source