Results 171 to 180 of about 25,920 (226)

Discovery of Novel Piperidinyl-Based Benzoxazole Derivatives as Anticancer Agents Targeting VEGFR-2 and c-Met Kinases. [PDF]

Pharmaceuticals (Basel)
Eldehna WM, Elsayed ZM, Elnagar MR, El-Said AH, Majrashi TA, Negmeldin AT, Saleh AM, Elrayess R, Elnahriry KA, Chen ZL, Elagawany M, Tawfik HO.   +11 more
europepmc   +1 more source

Molecular Subtyping and Prognostic Prediction in Pancreatic Cancer Based on Mitophagy-Related Genes. [PDF]

Int J Med Sci
Cai Y, Yue T, Ma Y, Liu G, Zhang J, Rong L.   +5 more
europepmc   +1 more source

Thapsigargin triggers a non-apoptotic, caspase-independent programmed cell death in basophilic leukaemia cells. [PDF]

Cell Death Discov
Steiner P, Melek K, Andosch A, Wiesbauer L, Madlmayr A, Duggan M, Kerschbaum HH, Zierler S.   +7 more
europepmc   +1 more source

Staurosporine Analogs Via C–H Borylation

ACS Medicinal Chemistry Letters, 2020
Staurosporine is among the most potent naturally occurring kinase inhibitors isolated to date and has served as a lead compound for numerous drug development efforts in several therapeutic areas. Herein we report that C-H borylation chemistry provides access to analogs of staurosporine that were previously inaccessible to medicinal chemists who, in the
Joseph Taube, John Wood, Keighley N Reisenauer   +2 more
exaly   +4 more sources

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Inhibition of aldosterone biosynthesis by staurosporine

Biological Chemistry, 2005
AbstractStaurosporine (STS) is a very potent broad-range kinase inhibitor, and its antiproliferative properties made it a lead compound for protein kinase C (PKC) inhibitors with therapeutic potential. Because STS also causes hypotension, we investigated in this study whether it directly interferes with the terminal steps of aldosterone biosynthesis ...
Matthias, Bureik, Alexander, Mion, Christopher J, Kenyon, Rita, Bernhardt   +3 more
openaire   +2 more sources

Molecular mechanism of staurosporine-induced apoptosis in osteoblasts

Pharmacological Research, 2000
Staurosporine, a microbial alkaloid, is a strong inhibitor of protein kinases. We induced apoptosis in murine osteoblast MC3T3E-1 cells by exposure to the staurosporine. Staurosporine transiently increased the phosphotransferase activity of c-Jun N-terminal kinase-1 (JNK1), which in turn may activate the transcriptional activity of activating protein-1
Hyung-Min Kim, Soo-Wan Chae, Han-Jung Chae   +2 more
exaly   +3 more sources

ChemInform Abstract: First Total Synthesis of Staurosporine and ent‐Staurosporine.

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
J. T. LINK, S. RAGHAVAN, S. J. DANISHEFSKY   +2 more
openaire   +1 more source

Synthesis of the staurosporine aglycone

Journal of the Chemical Society, Chemical Communications, 1990
The staurosporine aglycone 3 has been synthesised in 22.6% overall yield from ethyl indole-2-acetate by a route which involves an intramolecular Diels–Alder reaction of the pyranoindolone 8 followed by nitrene mediated cyclisation.
Christopher J. Moody, Kulsum F. Rahimtoola   +1 more
openaire   +1 more source

Characterization of staurosporine-sensitive mutants of Saccharomyces cerevisiae: vacuolar functions affect staurosporine sensitivity

Molecular and General Genetics MGG, 2000
Mutations at several loci affect the sensitivity of the yeast Saccharomyces cerevisiae to staurosporine. We report here the characterization of novel staurosporine- and temperature-sensitive mutants (stt). Cloning and integration mapping showed that the genes STT2/ STT6, STT5, STT7, STT8 and STT9 are allelic to VPS18, ERG10, GPI1, VPS34 and VPS11 ...
S, Yoshida, Y, Anraku
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Synthesis of the staurosporine aglycon

The Journal of Organic Chemistry, 1992
A short synthesis of the staurosporine aglycon (6) is reported, the indolocarbazole skeleton being constructed by an intramolecular Diels-Alder reaction followed by a nitrene-mediated ring closure. The synthesis starts by acylation of ethyl indole-2-acetate with oxalyl chloride.
Christopher J. Moody, Kulsum F. Rahimtoola, Barry Porter, Barry C. Ross   +3 more
openaire   +1 more source