Results 171 to 180 of about 27,930 (225)

Characterization of staurosporine-sensitive mutants of Saccharomyces cerevisiae: vacuolar functions affect staurosporine sensitivity

Molecular and General Genetics MGG, 2000
Mutations at several loci affect the sensitivity of the yeast Saccharomyces cerevisiae to staurosporine. We report here the characterization of novel staurosporine- and temperature-sensitive mutants (stt). Cloning and integration mapping showed that the genes STT2/ STT6, STT5, STT7, STT8 and STT9 are allelic to VPS18, ERG10, GPI1, VPS34 and VPS11 ...
S, Yoshida, Y, Anraku
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Molecular Mechanism of Staurosporine-Induced Apoptosis in Osteoblasts

Pharmacological Research, 2000
Staurosporine, a microbial alkaloid, is a strong inhibitor of protein kinases. We induced apoptosis in murine osteoblast MC3T3E-1 cells by exposure to the staurosporine. Staurosporine transiently increased the phosphotransferase activity of c-Jun N-terminal kinase-1 (JNK1), which in turn may activate the transcriptional activity of activating protein-1
Hyung-Min Kim, Soo-Wan Chae, Han-Jung Chae   +2 more
exaly   +3 more sources

Synthesis of the staurosporine aglycon

The Journal of Organic Chemistry, 1992
A short synthesis of the staurosporine aglycon (6) is reported, the indolocarbazole skeleton being constructed by an intramolecular Diels-Alder reaction followed by a nitrene-mediated ring closure. The synthesis starts by acylation of ethyl indole-2-acetate with oxalyl chloride.
Christopher J. Moody, Kulsum F. Rahimtoola, Barry Porter, Barry C. Ross   +3 more
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Biosynthesis of Staurosporine, 2. Incorporation of Tryptophan

Journal of Natural Products, 1988
Following studies to define the time course, media, and nutrient parameters for the production of the potent cytotoxic antibiotic staurosporine in Streptomyces staurosporeus, biosynthetic studies of staurosporine with singly- and doubly-labeled radioactive precursors established that either one or two units of tryptophan was incorporated efficiently ...
D, Meksuriyen, G A, Cordell
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Induction of a Common Pathway of Apoptosis by Staurosporine

Experimental Cell Research, 1994
The present observations show that staurosporine can rapidly trigger both the morphological changes and intranucleosomal DNA fragmentation typical of apoptosis. This occurred in a number of cell lines from various origins regardless of the state of differentiation and cell cycle phase, suggesting the presence of a common inducible suicide pathway.
R, Bertrand, E, Solary, P, O'Connor, K W, Kohn, Y, Pommier   +4 more
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Total Synthesis of Staurosporine

1997
Abstract Discussion Points What is the structure of the intermediate formed in step d? Suggest a reason for the closure of the oxazoline ring on the 8-face (formation of 4) and not on the a-face. Step j yielded a 2.5:1 mixture of a.:8 epoxides. Give reasons for the low stereoselectivity observed. The minor epoxide was found to react less
J T Link, S Raghavan, S J Danishefsky,
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DISCORDANCE BETWEEN THE EFFECT OF MODULATORS OF CALCIUM ON STAUROSPORINE‐INDUCED APOPTOSIS AND STAUROSPORINE‐INDUCED ACTIN DEGRADATION

Cell Biology International, 2002
AbstractStaurosporine produced DNA fragmentation characteristic of apoptosis and a dramatic alteration of cell structure that include alterations of cytoskeletal actin and cytoplasmic condensation with vacuolization. These changes were not induced by chelerythrine, a more specific PKC inhibitor than staurosporine.
Simon W, Rabkin, Jennifer Y, Kong
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Synthesis of Staurosporine Aglycon

1997
Abstract Discussion Points What is the mechanism of step b? Propose a mechanism for the transformation covered in step f. Simply refluxing compound 7 under an inert atmosphere in bromobenzene gave a product 10 in high yield. In the proton NMR spectrum of this product there were the following signals integrating for single protons; o 3.28
C J Moody, K F Rahimtoola, B Porter, B C Ross,   +3 more
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Biosynthesis of Staurosporine:  Incorporation of Glucose

Journal of Natural Products, 1996
Previously, it was disclosed that tryptophan provides two units of the basic building blocks involved in the biosynthesis of the indolo[2,3-a]carbazole unit of staurosporine (1). In this paper we describe the incorporation of [1-13C]-d-glucose and [U-13C6]-d-glucose into staurosporine, through which it was established that the amino-sugar moiety is ...
Shu-Wei Yang, Geoffrey A. Cordell
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A facile synthesis of staurosporine aglycone

Tetrahedron Letters, 1994
Abstract A highly efficient method is described for the synthesis of staurosporine aglycone 3 from the readily available dibromomaleic acid in six steps.
Guojian Xie, J. William Lown
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