Results 181 to 190 of about 27,930 (225)
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Staurosporine-induced neurite outgrowth in PC12h cells
Experimental Cell Research, 1989Treatment of PC12h cells with staurosporine (100 nM), a potent inhibitor of protein kinases, promoted rapid outgrowth of neurites. The mechanism of neurite formation elicited by staurosporine is different from that elicited by nerve growth factor or by dibutyryl cyclic AMP, based on the independence from transcription or from activation of cyclic AMP ...
S, Hashimoto, A, Hagino
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Stabilization of blood platelet microtubular system by staurosporine
Life Sciences, 1989The stimulative effects of phorbol myristate acetate (PMA) on rabbit platelet shape change and platelet adhesion were completely inhibited by staurosporine (STS)-pretreatment. When the platelets were observed by whole mount immuno transmission electron microscopy (TEM), STS was found to stabilize platelet microtubular cytoskeleton.
N, Ishihara, M, Iwama, B, Kobayashi
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Effects of Staurosporine on Transcription by Vesicular Stomatitis Virus
Virology, 1993The protein kinase inhibitor staurosporine has been found to inhibit vesicular stomatitis virus transcription in infected BHK cells. Both primary and secondary transcription were virtually abolished by 10 microM staurosporine. In contrast, transcription by purified virions, or by nucleocapsids isolated from them, was unaffected by staurosporine ...
K D, Rigaut, Y, Gao, J, Lenard
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Mechanism of staurosporine-induced apoptosis in murine hepatocytes
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2002Staurosporine (STS) induces apoptosis in various cell lines. We report in this study that primary cultured mouse hepatocytes are less sensitive to STS compared with Jurkat cells and Huh-7 cells. In contrast to the cell lines, no apparent release of cytochrome c or loss of mitochondrial transmembrane potential was detected in primary hepatocytes ...
Guoping, Feng, Neil, Kaplowitz
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Natural Staurosporine Derivatives with Fluorescence for Cancer Theranostics
ChemMedChemIn recent years, developing effective theranostic agents for precise cancer treatment has been one of the most prevalent strategies. Herein, three staurosporine derivatives, MCY‐STS, ECY‐STS, and ICY‐STS, synthesized through minor modifications of natural staurosporine, are reported. These derivatives not only exhibit attractive fluorescence properties,
Kualiang Li +10 more
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First Total Synthesis of Staurosporine and ent-Staurosporine
Journal of the American Chemical Society, 1995J. T. Link +2 more
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Staurosporine Analogs via C–H Borylation
ACS Medicinal Chemistry Letters, 2020Joseph H Taube +2 more
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