Results 181 to 190 of about 25,920 (226)

DISCORDANCE BETWEEN THE EFFECT OF MODULATORS OF CALCIUM ON STAUROSPORINE-INDUCED APOPTOSIS AND STAUROSPORINE-INDUCED ACTIN DEGRADATION

Cell Biology International, 2002
AbstractStaurosporine produced DNA fragmentation characteristic of apoptosis and a dramatic alteration of cell structure that include alterations of cytoskeletal actin and cytoplasmic condensation with vacuolization. These changes were not induced by chelerythrine, a more specific PKC inhibitor than staurosporine.
Simon Rabkin
exaly   +3 more sources

Simplified staurosporine analogs as potent JAK3 inhibitors

Bioorganic and Medicinal Chemistry Letters, 2007
Simplification of bottom ring and regioselective functionalization of the indolocarbazole unit of staurosporine (2) are described. The modification led to a new series of simplified staurosporine analogs, which exhibited significant inhibitory activity against Janus kinase 3 (JAK3).
Ravi Malaviya, William V Murray, Lawrence J Wilson   +2 more
exaly   +3 more sources

Biosynthesis of Staurosporine, 2. Incorporation of Tryptophan

Journal of Natural Products, 1988
Following studies to define the time course, media, and nutrient parameters for the production of the potent cytotoxic antibiotic staurosporine in Streptomyces staurosporeus, biosynthetic studies of staurosporine with singly- and doubly-labeled radioactive precursors established that either one or two units of tryptophan was incorporated efficiently ...
D, Meksuriyen, G A, Cordell
openaire   +2 more sources

Induction of a Common Pathway of Apoptosis by Staurosporine

Experimental Cell Research, 1994
The present observations show that staurosporine can rapidly trigger both the morphological changes and intranucleosomal DNA fragmentation typical of apoptosis. This occurred in a number of cell lines from various origins regardless of the state of differentiation and cell cycle phase, suggesting the presence of a common inducible suicide pathway.
R, Bertrand, E, Solary, P, O'Connor, K W, Kohn, Y, Pommier   +4 more
openaire   +2 more sources

Total Synthesis of Staurosporine

1997
Abstract Discussion Points What is the structure of the intermediate formed in step d? Suggest a reason for the closure of the oxazoline ring on the 8-face (formation of 4) and not on the a-face. Step j yielded a 2.5:1 mixture of a.:8 epoxides. Give reasons for the low stereoselectivity observed. The minor epoxide was found to react less
J T Link, S Raghavan, S J Danishefsky,
openaire   +1 more source

Synthesis of Staurosporine Aglycon

1997
Abstract Discussion Points What is the mechanism of step b? Propose a mechanism for the transformation covered in step f. Simply refluxing compound 7 under an inert atmosphere in bromobenzene gave a product 10 in high yield. In the proton NMR spectrum of this product there were the following signals integrating for single protons; o 3.28
C J Moody, K F Rahimtoola, B Porter, B C Ross,   +3 more
openaire   +1 more source

Biosynthesis of Staurosporine:  Incorporation of Glucose

Journal of Natural Products, 1996
Previously, it was disclosed that tryptophan provides two units of the basic building blocks involved in the biosynthesis of the indolo[2,3-a]carbazole unit of staurosporine (1). In this paper we describe the incorporation of [1-13C]-d-glucose and [U-13C6]-d-glucose into staurosporine, through which it was established that the amino-sugar moiety is ...
Shu-Wei Yang, Geoffrey A. Cordell
openaire   +1 more source

A facile synthesis of staurosporine aglycone

Tetrahedron Letters, 1994
Abstract A highly efficient method is described for the synthesis of staurosporine aglycone 3 from the readily available dibromomaleic acid in six steps.
Guojian Xie, J. William Lown
openaire   +1 more source

Staurosporine-induced neurite outgrowth in PC12h cells

Experimental Cell Research, 1989
Treatment of PC12h cells with staurosporine (100 nM), a potent inhibitor of protein kinases, promoted rapid outgrowth of neurites. The mechanism of neurite formation elicited by staurosporine is different from that elicited by nerve growth factor or by dibutyryl cyclic AMP, based on the independence from transcription or from activation of cyclic AMP ...
S, Hashimoto, A, Hagino
openaire   +2 more sources

Stabilization of blood platelet microtubular system by staurosporine

Life Sciences, 1989
The stimulative effects of phorbol myristate acetate (PMA) on rabbit platelet shape change and platelet adhesion were completely inhibited by staurosporine (STS)-pretreatment. When the platelets were observed by whole mount immuno transmission electron microscopy (TEM), STS was found to stabilize platelet microtubular cytoskeleton.
N, Ishihara, M, Iwama, B, Kobayashi
openaire   +2 more sources