Results 131 to 140 of about 1,264 (145)

Glycophagy: An emerging target in pathology

Clinica Chimica Acta, 2018
Autophagy, a highly conserved self-digestion process, is initially regarded as non-selectively sequestering and degradation cytoplasmic contents. Nowadays, many kinds of selective autophagy have been found in response to various physiological cues such ...
Pingbo Yao, Lin-xi Chen
exaly   +2 more sources

STBD1 (Starch-domain-containing-binding-protein 1) Modulates Myocardial Glycogen Handling in Systemic Metabolic Challenge

Heart, Lung and Circulation, 2021
S. Hayes, U. Varma, C. Curl, A. Raaijmakers, L. Delbridge   +4 more
openaire   +2 more sources

Investigating STarch Binding Domain Containing Protein 1 (STBD1) as a Physiologic Regulator of Cardiac Functional and Metabolic Homeostasis

Heart, Lung and Circulation
A. Chau, U. Varma, A. Raaijmakers, K. Weeks, C. Curl, K. Mellor, L. Delbridge   +6 more
openaire   +2 more sources

The glycogen cargo receptor STBD1: from biology to disease targeted therapies

2022
Glycophagy is a novel selective autophagy characterized by glycogen degradation via the lysosomal enzyme acid α-glucosidase (GAA). Starch-binding domain-containing protein 1 (STBD1) is a glycogen cargo receptor that mediates glycophagy through binding glycogen transport into lysosomes.
Qiannan Tang, Meiqing Liu, Hong Zhao, Linxi Chen   +3 more
openaire   +1 more source

Single-cell RNA-seq reveals different subsets of non-specific cytotoxic cells in teleost.

Genomics, 2020
Non-specific cytotoxic cells (NCC) are important cytotoxic leukocytes in teleost immune system. However, the NCC subsets have not been clarified. Thus, we create a comprehensive cell map of ~24,062 head kidney-derived leukocytes from Nile tilapia post ...
J. Niu, Yu Huang, Xinchao Liu, Zhiqiang Zhang, Jufen Tang, Bei Wang, Yishan Lu, Jia Cai, J. Jian   +8 more
semanticscholar   +1 more source

Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues

bioRxiv
Diabetic heart disease is highly prevalent and is associated with the early development of impaired diastolic relaxation. The mechanisms of diabetic heart disease are poorly understood and it is a condition for which there are no targeted therapies ...
Prof Lea, MD Delbridge, K. Mellor, U. Varma, P. Koutsifeli, C. Curl, J. Janssens, L. J. Daniels, G. Bernasochi, A. Raaijmakers, M. Annandale, X. Li, S. James, D. J. Taylor, K. Raedschelders, K. Weeks, R. J. Mills, R. G. Parton, X. Hu, J. Bell, T. J. O’Brien, R. Katare, E. Porrello, J. Hudson, R. Xiao, J. E. Eyk, R. A. Gottlieb, L. Delbridge   +27 more
semanticscholar   +2 more sources

Paired copy number variation analysis in siblings discordant for familial Parkinson’s disease

Annals of Clinical Biochemistry
Objectives Numerous studies on the genetic pathogenesis of familial Parkinson’s Disease (PD) have explained the etiology of only a limited percentage of cases. In this study, we aimed to identify copy number variations (CNVs) in patients with familial PD
S. Atay, A. Acarer, Handan Ak, Zafer Colakoglu, H. Aydin   +4 more
semanticscholar   +1 more source

Chemical genetic screen identifies Gapex-5/GAPVDI and STBD1 as novel AMPK substrates.

2019
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis, acting as a sensor of energy and nutrient status. As such, AMPK is considered a promising drug target for treatment of medical conditions particularly associated with metabolic dysfunctions. To better understand the downstream effectors and physiological consequences
Ducommun, S., Deak, M., Zeigerer, A., Göransson, O., Seitz, S., Collodet, C., Madsen, A.B., Jensen, T.E., Viollet, B., Foretz, M., Gut, P., Sumpton, D., Sakamoto, K.   +12 more
openaire   +1 more source

Mouse Stbd1 is N-myristoylated and affects ER–mitochondria association and mitochondrial morphology

Journal of Cell Science, 2017
Julia Morales-Sanfrutos, Kyriacos Kyriacou, Edward W Tate   +2 more
exaly  

Cardiomyocyte glycophagy is regulated by insulin and exposure to high extracellular glucose.

American Journal of Physiology. Heart and Circulatory Physiology, 2014
K. Mellor, U. Varma, D. Stapleton, L. Delbridge   +3 more
semanticscholar   +1 more source