Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens [PDF]
Cells, 2022 As a predominant hormone in the reproductive axis, follicle-stimulating hormone (FSH) is known as the primary surviving factor for follicular growth. In this study, the alleviating effect of FSH on aging chicken granulosa cells (GCs) was investigated ...
Changquan Guo, Caiqiao Zhang
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Dysfunction of astrocytic glycophagy exacerbates reperfusion injury in ischemic stroke [PDF]
Redox BiologyGlycophagy has evolved from an alternative glycogen degradation pathway into a multifaceted pivot to regulate cellular metabolic hemostasis in peripheral tissues.
Haiyun Guo, Wugang Hou, Hua-Ning Wang
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ROS generation attenuates the anti-cancer effect of CPX on cervical cancer cells by inducing autophagy and inhibiting glycophagy [PDF]
Redox Biology, 2022 Cervical cancer is one of the most common gynecological malignancies with poor prognosis due to constant chemoresistance and repeated relapse. Ciclopirox olamine (CPX), a synthetic antifungal agent, has recently been identified to be a promising anti ...
Yunlong Lei, Youquan Bu
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Glycophagy is involved in cardiac glycogen regulation in response to exercise [PDF]
Current Research in PhysiologyCardiac glycogen-autophagy (‘glycophagy’) is disturbed in cardiometabolic pathologies. The physiological role of cardiac glycophagy is unclear. Exercise induces transient cardiac glycogen accumulation.
Parisa Koutsifeli, Kimberley M Mellor
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Glycogen-autophagy: Molecular machinery and cellular mechanisms of glycophagy [PDF]
Journal of Biological Chemistry, 2022 Autophagy is an essential cellular process involving degradation of superfluous or defective macromolecules and organelles as a form of homeostatic recycling. Initially proposed to be a "bulk" degradation pathway, a more nuanced appreciation of selective autophagy pathways has developed in the literature in recent years.
Parisa Koutsifeli +2 more
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Glycophagy is an ancient bilaterian pathway supporting metabolic adaptation through STBD1 structural evolution [PDF]
Communications BiologyGlycophagy, a selective form of autophagy critical for glycogen homeostasis, relies on the glycogen cargo receptor called starch-binding domain-containing protein 1 (STBD1), yet its evolutionary origins remain elusive.
Liting Ren +6 more
doaj +5 more sources
Lysosomal glucose sensing and glycophagy in metabolism [PDF]
Trends in Endocrinology and Metabolism, 2023 Lysosomes are cellular organelles that function to catabolize both extra- and intracellular cargo, act as a platform for nutrient sensing, and represent a core signaling node integrating bioenergetic cues to changes in cellular metabolism. Although lysosomal amino acid and lipid sensing in metabolism has been well characterized, lysosomal glucose ...
Melina Mancini +2 more
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Asiatic Acid Alleviates Renal Damage by Upregulating STBD1-Mediated Glycophagy in Diabetic Kidney Disease [PDF]
BiomedicinesBackground/Objectives: The role of glycogen metabolism in diabetic kidney disease (DKD) remains unclear. This study investigated the therapeutic potential of asiatic acid (AA) on glycogen metabolism in DKD and its underlying mechanisms.
Lei Guo +16 more
doaj +3 more sources
Glycophagy: molecular mechanisms, regulatory signals, and disease associations [PDF]
Autophagy ReportsGlycophagy is a process of selective degradation of glycogen through the autophagy pathway. It relies on key proteins, such as STBD1 (glycogen-specific autophagy receptor), GABARAPL1 (member of the ATG8 family), and acid α-glucosidase (GAA), and proceeds
Lei Chen +3 more
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Regulation and role of glycophagy in skeletal muscle energy metabolism [PDF]
Autophagy, 2022 Glycophagy is the autophagic degradation of glycogen via the lysosomal enzyme GAA/alpha-acid glucosidase. Glycophagy is considered a housekeeping process to degrade poorly branched glycogen particles, but the regulation and role of glycophagy in skeletal muscle metabolism remains enigmatic.
Timothy D Heden +2 more
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