Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens [PDF]
Cells, 2022 As a predominant hormone in the reproductive axis, follicle-stimulating hormone (FSH) is known as the primary surviving factor for follicular growth. In this study, the alleviating effect of FSH on aging chicken granulosa cells (GCs) was investigated ...
Caiqiao Zhang +2 more
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Dysfunction of astrocytic glycophagy exacerbates reperfusion injury in ischemic stroke [PDF]
Redox BiologyGlycophagy has evolved from an alternative glycogen degradation pathway into a multifaceted pivot to regulate cellular metabolic hemostasis in peripheral tissues.
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Glycophagy is involved in cardiac glycogen regulation in response to exercise [PDF]
Current Research in PhysiologyCardiac glycogen-autophagy (‘glycophagy’) is disturbed in cardiometabolic pathologies. The physiological role of cardiac glycophagy is unclear. Exercise induces transient cardiac glycogen accumulation.
Troy Merry +2 more
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Asiatic Acid Alleviates Renal Damage by Upregulating STBD1-Mediated Glycophagy in Diabetic Kidney Disease [PDF]
BiomedicinesBackground/Objectives: The role of glycogen metabolism in diabetic kidney disease (DKD) remains unclear. This study investigated the therapeutic potential of asiatic acid (AA) on glycogen metabolism in DKD and its underlying mechanisms.
Lin Xiaochun, Peili Wu
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Glycophagy is an ancient bilaterian pathway supporting metabolic adaptation through STBD1 structural evolution [PDF]
Communications BiologyGlycophagy, a selective form of autophagy critical for glycogen homeostasis, relies on the glycogen cargo receptor called starch-binding domain-containing protein 1 (STBD1), yet its evolutionary origins remain elusive.
Liting Ren +6 more
doaj +4 more sources
Methods for detection of cardiac glycogen-autophagy [PDF]
Autophagy ReportsGlycogen-autophagy (‘glycophagy’) is a selective autophagy process involved in delivering glycogen to the lysosome for bulk degradation. Glycophagy protein intermediaries include STBD1 as a glycogen tagging receptor, delivering the glycogen cargo into ...
Parisa Koutsifeli +14 more
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ROS generation attenuates the anti-cancer effect of CPX on cervical cancer cells by inducing autophagy and inhibiting glycophagy [PDF]
Redox Biology, 2022 Cervical cancer is one of the most common gynecological malignancies with poor prognosis due to constant chemoresistance and repeated relapse. Ciclopirox olamine (CPX), a synthetic antifungal agent, has recently been identified to be a promising anti ...
Yunlong Lei +2 more
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Glycophagy: molecular mechanisms, regulatory signals, and disease associations [PDF]
Autophagy ReportsGlycophagy is a process of selective degradation of glycogen through the autophagy pathway. It relies on key proteins, such as STBD1 (glycogen-specific autophagy receptor), GABARAPL1 (member of the ATG8 family), and acid α-glucosidase (GAA), and proceeds
Lx Chen
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Enhanced lysosomal glycogen breakdown is associated with liver tumorigenesis in glycogen storage disease type III [PDF]
JHEP ReportsBackground & Aims: Glycogen storage disease type III (GSDIII) is a rare metabolic disorder caused by mutations in the glycogen debranching enzyme (AGL), leading to hepatic glycogen accumulation, fibrosis and increased hepatocellular carcinoma (HCC ...
Valle Montalvo-Romeral +26 more
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Glycogen is a neutral cargo of bulk autophagy in Komagataella phaffii [PDF]
Autophagy ReportsGlycogen is a primary cellular energy store in numerous eukaryotes. Its biosynthesis is a main strategy to cope with forthcoming starvation. During starvation, glycogen is processed in the cytosol or delivered for degradation to animal lysosomes or yeast
Nimna V. Wijewantha, Taras Y. Nazarko
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