Heterozygous GAA knockout is nonconsequential on metabolism and the spatial liver transcriptome in high‐fat diet‐induced obese and prediabetic mice [PDF]
Physiological ReportsGlycophagy is the autophagic degradation of glycogen by the enzyme acid alpha‐glucosidase (GAA). Although GAA inhibitors improve metabolic health by inhibiting GAA in the intestine, it is not clear if GAA inhibition in peripheral tissues such as the ...
Cameron P. McCall +4 more
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Rab4b controls hepatic glucose production during fasting through glycophagy [PDF]
Nature CommunicationsHepatic glucose production, essential for maintaining glycemia, is often altered in metabolic-associated fatty liver and glycogen storage diseases. Therefore, understanding the mechanisms that regulate the glucose production by hepatocyte is pivotal ...
Marion Dussot +18 more
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Atg45 is an autophagy receptor for glycogen, a non-preferred cargo of bulk autophagy in yeast [PDF]
iScienceSummary: The mechanisms governing autophagy of proteins and organelles have been well studied, but how other cytoplasmic components such as RNA and polysaccharides are degraded remains largely unknown.
Takahiro Isoda +4 more
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Glycogen-autophagy: Molecular machinery and cellular mechanisms of glycophagy [PDF]
Journal of Biological Chemistry, 2022 Autophagy is an essential cellular process involving degradation of superfluous or defective macromolecules and organelles as a form of homeostatic recycling. Initially proposed to be a "bulk" degradation pathway, a more nuanced appreciation of selective
Kate Weeks +2 more
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Glycogen Granules Are Degraded by Non-Selective Autophagy in Nitrogen-Starved Komagataella phaffii [PDF]
CellsAutophagy was initially recognized as a bulk degradation process that randomly sequesters and degrades cytoplasmic material in lysosomes (vacuoles in yeast). In recent years, various types of selective autophagy have been discovered.
Nimna V. Wijewantha +2 more
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Autophagy of glycogen is non-selective in Komagataella phaffii [PDF]
Autophagy ReportsGlycogen is an important reserve polysaccharide from bacteria to human. It is organized in glycogen granules that also contain several proteins involved in their metabolism.
Taras Y. Nazarko
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Lysosomal glucose sensing and glycophagy in metabolism [PDF]
Trends in Endocrinology and Metabolism, 2023 Lysosomes are cellular organelles that function to catabolize both extra- and intracellular cargo, act as a platform for nutrient sensing, and represent a core signaling node integrating bioenergetic cues to changes in cellular metabolism.
Mélina Mancini +2 more
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Gluconeogenesis and glycogenolysis required in metastatic breast cancer cells [PDF]
Frontiers in OncologyIntroductionMetabolic adaptability, including glucose metabolism, enables cells to survive multiple stressful environments. Glycogen may serve as a critical storage depot to provide a source of glucose during times of metabolic demand during the ...
Emily Hicks +12 more
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Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation
Cell Reports, 2019 Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases.
Alicia Mayeuf-Louchart +20 more
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The “sweet” side of ER-mitochondria contact sites
Communicative & Integrative Biology, 2017 The regions at which the ER and mitochondria come into close proximity, known as ER-mitochondria contact sites provide essential platforms for the exchange of molecules between the two organelles and the coordination of various fundamental cellular ...
Anthi Demetriadou +2 more
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