Results 11 to 20 of about 473 (103)

Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity. [PDF]

J Cereb Blood Flow Metab, 2021
Autophagy is essential to cell function, as it enables the recycling of intracellular constituents during starvation and in addition functions as a quality control mechanism by eliminating spent organelles and proteins that could cause cellular damage if not properly removed.
Napoli E, Panoutsopoulos AA, Kysar P, Satriya N, Sterling K, Shibata B, Imai D, Ruskin DN, Zarbalis KS, Giulivi C.   +9 more
europepmc   +8 more sources

Methods for detection of cardiac glycogen-autophagy [PDF]

Autophagy Reports
Glycogen-autophagy (‘glycophagy’) is a selective autophagy process involved in delivering glycogen to the lysosome for bulk degradation. Glycophagy protein intermediaries include STBD1 as a glycogen tagging receptor, delivering the glycogen cargo into ...
Parisa Koutsifeli, Lorna J. Daniels, Joshua Neale, Sarah Fong, Upasna Varma, Marco Annandale, Xun Li, Yohanes Nursalim, James R. Bell, Kate L. Weeks, Aleksandr Stotland, David J. Taylor, Roberta A. Gottlieb, Lea M.D. Delbridge, Kimberley M. Mellor   +14 more
doaj   +7 more sources

Myocardial glycophagy flux dysregulation and glycogen accumulation characterize diabetic cardiomyopathy

Journal of Molecular and Cellular Cardiology
Diabetic heart disease morbidity and mortality is escalating. No specific therapeutics exist and mechanistic understanding of diabetic cardiomyopathy etiology is lacking. While lipid accumulation is a recognized cardiomyocyte phenotype of diabetes, less is known about glycolytic fuel handling and storage.
Upasna Varma, Marco Annandale, Johannes V Janssens   +2 more
exaly   +6 more sources

Heterozygous GAA knockout is nonconsequential on metabolism and the spatial liver transcriptome in high‐fat diet‐induced obese and prediabetic mice [PDF]

Physiological Reports
Glycophagy is the autophagic degradation of glycogen by the enzyme acid alpha‐glucosidase (GAA). Although GAA inhibitors improve metabolic health by inhibiting GAA in the intestine, it is not clear if GAA inhibition in peripheral tissues such as the ...
Cameron P. McCall, Melina C. Mancini, Jaroslaw Staszkiewicz, Douglas G. Mashek, Timothy D. Heden   +4 more
doaj   +4 more sources

Atg45 is an autophagy receptor for glycogen, a non-preferred cargo of bulk autophagy in yeast [PDF]

iScience
Summary: The mechanisms governing autophagy of proteins and organelles have been well studied, but how other cytoplasmic components such as RNA and polysaccharides are degraded remains largely unknown.
Takahiro Isoda, Eigo Takeda, Sachiko Hosokawa, Shukun Hotta-Ren, Yoshinori Ohsumi   +4 more
doaj   +4 more sources

Myocardial glycophagy — A specific glycogen handling response to metabolic stress is accentuated in the female heart [PDF]

Journal of Molecular and Cellular Cardiology, 2013
Cardiac metabolic stress is a hallmark of many cardiac pathologies, including diabetes. Cardiac glycogen mis-handling is a frequent manifestation of various cardiopathologies. Diabetic females have a higher risk of heart disease than males, yet sex disparities in cardiac metabolic stress settings are not well understood.
Melissa E Reichelt, Kimberley M Mellor
exaly   +9 more sources

Osteocalcin modulates hippocampal activities and influences glycophagy within astrocytes in a chronic unpredictable mild stress mouse model [PDF]

Comprehensive Psychoneuroendocrinology
Osteocalcin (OCN), an active substance produced by bone tissue, has demonstrated potential in alleviating depressive symptoms and exerting extensive regulatory effects on glial cells in animals by participating in the communication between bone and brain, while its precise mechanisms within the central nervous system (CNS) still not fully understood ...
Chen H, Mao J, Wang M, Zhang Q, Zheng R, Wu Y, Ma X, Liu Q.   +7 more
exaly   +6 more sources

Glycogen Granules Are Degraded by Non-Selective Autophagy in Nitrogen-Starved Komagataella phaffii [PDF]

Cells
Autophagy was initially recognized as a bulk degradation process that randomly sequesters and degrades cytoplasmic material in lysosomes (vacuoles in yeast). In recent years, various types of selective autophagy have been discovered.
Nimna V. Wijewantha, Ravinder Kumar, Taras Y. Nazarko   +2 more
doaj   +4 more sources

Sacubitril/valsartan combination enhanced cardiac glycophagy and prevented the progression of murine diabetic cardiomyopathy

Biomedicine and Pharmacotherapy, 2022
Diabetic cardiomyopathy (DCM) is linked to disturbance in cardiac glucose handling and increased cardiac glycogen storage. This study tested the potential role of sacubitril/valsartan on the progression of DCM in high fat diet (HFD)/streptozotocin (STZ)-induced type 2 diabetic rats compared to valsartan alone, including their effects on the cardiac ...
Dina Salem Abdelaziz, Elshenawy, Nehal Mohammed, Ramadan, Vivian Boshra, Abdo, Rehab Hamdy, Ashour   +3 more
exaly   +4 more sources

Asiatic acid alleviates ischemic myocardial injury in mice by modulating mitophagy- and glycophagy-based energy metabolism. [PDF]

Acta Pharmacol Sin, 2022
Myocardial infarction (MI) causes disturbances in myocardial energy metabolism, ultimately leading to a poor prognosis. Cytosolic glycogen autophagy (glycophagy) and mitochondrial autophagy (mitophagy) are upregulated in MI to optimize energy metabolism but to a limited extent.
Qiu F, Yuan Y, Luo W, Gong YS, Zhang ZM, Liu ZM, Gao L.   +6 more
europepmc   +4 more sources