Results 11 to 20 of about 576 (126)

Heterozygous GAA knockout is nonconsequential on metabolism and the spatial liver transcriptome in high‐fat diet‐induced obese and prediabetic mice [PDF]

Physiological Reports
Glycophagy is the autophagic degradation of glycogen by the enzyme acid alpha‐glucosidase (GAA). Although GAA inhibitors improve metabolic health by inhibiting GAA in the intestine, it is not clear if GAA inhibition in peripheral tissues such as the ...
Cameron P. McCall, Melina C. Mancini, Jaroslaw Staszkiewicz, Douglas G. Mashek, Timothy D. Heden   +4 more
doaj   +3 more sources

Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity. [PDF]

J Cereb Blood Flow Metab, 2021
Autophagy is essential to cell function, as it enables the recycling of intracellular constituents during starvation and in addition functions as a quality control mechanism by eliminating spent organelles and proteins that could cause cellular damage if not properly removed.
Napoli E, Panoutsopoulos AA, Kysar P, Satriya N, Sterling K, Shibata B, Imai D, Ruskin DN, Zarbalis KS, Giulivi C.   +9 more
europepmc   +5 more sources

Methods for detection of cardiac glycogen-autophagy [PDF]

Autophagy Reports
Glycogen-autophagy (‘glycophagy’) is a selective autophagy process involved in delivering glycogen to the lysosome for bulk degradation. Glycophagy protein intermediaries include STBD1 as a glycogen tagging receptor, delivering the glycogen cargo into ...
Parisa Koutsifeli, Lorna J. Daniels, Joshua Neale, Sarah Fong, Upasna Varma, Marco Annandale, Xun Li, Yohanes Nursalim, James R. Bell, Kate L. Weeks, Aleksandr Stotland, David J. Taylor, Roberta A. Gottlieb, Lea M.D. Delbridge, Kimberley M. Mellor   +14 more
doaj   +2 more sources

Enhanced lysosomal glycogen breakdown is associated with liver tumorigenesis in glycogen storage disease type III [PDF]

JHEP Reports
Background & Aims: Glycogen storage disease type III (GSDIII) is a rare metabolic disorder caused by mutations in the glycogen debranching enzyme (AGL), leading to hepatic glycogen accumulation, fibrosis and increased hepatocellular carcinoma (HCC ...
Valle Montalvo-Romeral, Louisa Jauze, Gwendoline Perrot, Mouna Amaouche, Antoine Gardin, Araceli Aguilar González, Alicia Leblond, Carine Zitoun-Ardon, Félicie Evrard, Jérémie Cosette, Christophe Tatout, Fanny Bordier, Emilie Bertil-Froidevaux, Christophe Georger, Laetitia van Wittenberghe, Valérie Paradis, Simon Gay, Fanny Dujardin, François Maillot, Amandine Gautier-Stein, Gilles Mithieux, Edoardo Malfatti, Charlotte Mussini, Philippe Labrune, Alicia Mayeuf-Louchart, Giuseppe Ronzitti, Fabienne Rajas   +26 more
doaj   +2 more sources

Model-based analysis uncovers mutations altering autophagy selectivity in human cancer. [PDF]

Nat Commun, 2021
Autophagy can selectively target protein aggregates, pathogens, and dysfunctional organelles for the lysosomal degradation. Aberrant regulation of autophagy promotes tumorigenesis, while it is far less clear whether and how tumor-specific alterations ...
Han Z, Zhang W, Ning W, Wang C, Deng W, Li Z, Shang Z, Shen X, Liu X, Baba O, Morita T, Chen L, Xue Y, Jia D.   +13 more
europepmc   +6 more sources

The ER - Glycogen Particle - Phagophore Triangle: A Hub Connecting Glycogenolysis and Glycophagy? [PDF]

Pathology & Oncology Research, 2019
Glycogen particle is an intracellular organelle, which serves as a carbohydrate reserve in various cells. The function of glycogen is not entirely known in several cell types.
Bánhegyi, Gábor, Mandl, József
core   +4 more sources

Biomedical Implications of Autophagy in Macromolecule Storage Disorders [PDF]

Frontiers in Cell and Developmental Biology, 2019
An imbalance between the production and clearance of macromolecules such as proteins, lipids and carbohydrates can lead to a category of diseases broadly known as macromolecule storage disorders.
Adina Maria Palhegyi, Elena Seranova, Simona Dimova, Sheabul Hoque, Sovan Sarkar   +4 more
doaj   +3 more sources

Glycophagy — the physiological perspective on a newly characterized glycogen-selective autophagy

Current Opinion in Physiology, 2022
Degradation of intracellular components through autophagy is a fundamental process to maintain cellular integrity and homeostasis. Recently a glycogen-selective autophagy pathway has been described, termed ‘glycophagy’. Glycogen is a primary storage depot and regulator of glucose availability, and glycophagy is emerging as a ...
Parisa Koutsifeli, Kate L Weeks, James R Bell   +2 more
exaly   +2 more sources

Glycogen is a neutral cargo of bulk autophagy in Komagataella phaffii [PDF]

Autophagy Reports
Glycogen is a primary cellular energy store in numerous eukaryotes. Its biosynthesis is a main strategy to cope with forthcoming starvation. During starvation, glycogen is processed in the cytosol or delivered for degradation to animal lysosomes or yeast
Nimna V. Wijewantha, Taras Y. Nazarko
doaj   +2 more sources

Sacubitril/valsartan combination enhanced cardiac glycophagy and prevented the progression of murine diabetic cardiomyopathy

Biomedicine and Pharmacotherapy, 2022
Diabetic cardiomyopathy (DCM) is linked to disturbance in cardiac glucose handling and increased cardiac glycogen storage. This study tested the potential role of sacubitril/valsartan on the progression of DCM in high fat diet (HFD)/streptozotocin (STZ)-induced type 2 diabetic rats compared to valsartan alone, including their effects on the cardiac ...
Rehab H Ashour
exaly   +3 more sources