Results 21 to 30 of about 473 (103)

Glycophagy — the physiological perspective on a newly characterized glycogen-selective autophagy

Current Opinion in Physiology, 2022
Degradation of intracellular components through autophagy is a fundamental process to maintain cellular integrity and homeostasis. Recently a glycogen-selective autophagy pathway has been described, termed ‘glycophagy’. Glycogen is a primary storage depot and regulator of glucose availability, and glycophagy is emerging as a ...
Lea M D Delbridge, Parisa Koutsifeli, Marco Annandale   +2 more
exaly   +3 more sources

The ER – Glycogen Particle – Phagophore Triangle: A Hub Connecting Glycogenolysis and Glycophagy? [PDF]

Pathology & Oncology Research, 2018
Glycogen particle is an intracellular organelle, which serves as a carbohydrate reserve in various cells. The function of glycogen is not entirely known in several cell types. Glycogen can be mobilized for different purposes, which can be related to cellular metabolic needs, intracellular redox state, metabolic state of the whole organism depending on ...
Mandl, József, Bánhegyi, Gábor
semanticscholar   +5 more sources

Autophagy of glycogen is non-selective in Komagataella phaffii [PDF]

Autophagy Reports
Glycogen is an important reserve polysaccharide from bacteria to human. It is organized in glycogen granules that also contain several proteins involved in their metabolism.
Taras Y. Nazarko
doaj   +3 more sources

Gluconeogenesis and glycogenolysis required in metastatic breast cancer cells [PDF]

Frontiers in Oncology
IntroductionMetabolic adaptability, including glucose metabolism, enables cells to survive multiple stressful environments. Glycogen may serve as a critical storage depot to provide a source of glucose during times of metabolic demand during the ...
Emily Hicks, Marjorie Anne Layosa, Marjorie Anne Layosa, Chaylen Andolino, Chaylen Andolino, Caitlin Truffer, Yazhen Song, Yazhen Song, Timothy D. Heden, Shawn S. Donkin, Shawn S. Donkin, Dorothy Teegarden, Dorothy Teegarden   +12 more
doaj   +3 more sources

STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma

Cell Reports
Summary: The accumulation of lipid droplets (LDs) and glycogen is a major hallmark of clear cell renal cell carcinoma (ccRCC), yet their interplay remains unclear.
Hao Wang, Tong Xiao, Hao Zhuang, Yi Liu, Kexing Jin, Jing Li, Jun Li, Yan Gao, Dan Yue, Wei Cui, Qingxia Xu, Jingxuan Pan, Kangdong Liu, Yong Wang, Ruibing Chen, Hongle Li   +15 more
doaj   +3 more sources

Corrigendum to “Sacubitril/valsartan combination enhanced cardiac glycophagy and prevented the progression of murine diabetic cardiomyopathy” [Biomed. Pharmacother. 153 (2022) 113382]

Biomedicine and Pharmacotherapy, 2022
Dina Salem Abdelaziz Elshenawy, Nehal Mohammed Ramadan, Vivian Boshra Abdo, Rehab Hamdy Ashour   +3 more
exaly   +3 more sources

Enhanced lysosomal glycogen breakdown is associated with liver tumorigenesis in glycogen storage disease type III [PDF]

JHEP Reports
Background & Aims: Glycogen storage disease type III (GSDIII) is a rare metabolic disorder caused by mutations in the glycogen debranching enzyme (AGL), leading to hepatic glycogen accumulation, fibrosis and increased hepatocellular carcinoma (HCC ...
Valle Montalvo-Romeral, Louisa Jauze, Gwendoline Perrot, Mouna Amaouche, Antoine Gardin, Araceli Aguilar González, Alicia Leblond, Carine Zitoun-Ardon, Félicie Evrard, Jérémie Cosette, Christophe Tatout, Fanny Bordier, Emilie Bertil-Froidevaux, Christophe Georger, Laetitia van Wittenberghe, Valérie Paradis, Simon Gay, Fanny Dujardin, François Maillot, Amandine Gautier-Stein, Gilles Mithieux, Edoardo Malfatti, Charlotte Mussini, Philippe Labrune, Alicia Mayeuf-Louchart, Giuseppe Ronzitti, Fabienne Rajas   +26 more
doaj   +2 more sources

Glycogen is a neutral cargo of bulk autophagy in Komagataella phaffii [PDF]

Autophagy Reports
Glycogen is a primary cellular energy store in numerous eukaryotes. Its biosynthesis is a main strategy to cope with forthcoming starvation. During starvation, glycogen is processed in the cytosol or delivered for degradation to animal lysosomes or yeast
Nimna V. Wijewantha, Taras Y. Nazarko
doaj   +2 more sources

Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation

Cell Reports, 2019
Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases.
Alicia Mayeuf-Louchart, Steve Lancel, Yasmine Sebti, Benoit Pourcet, Anne Loyens, Stéphane Delhaye, Christian Duhem, Justine Beauchamp, Lise Ferri, Quentin Thorel, Alexis Boulinguiez, Mathilde Zecchin, Julie Dubois-Chevalier, Jérôme Eeckhoute, Logan T. Vaughn, Peter J. Roach, Christian Dani, Bartholomew A. Pederson, Stéphane D. Vincent, Bart Staels, Hélène Duez   +20 more
doaj   +2 more sources

Myocardial autophagic energy stress responses—macroautophagy, mitophagy, and glycophagy

American Journal of Physiology-Heart and Circulatory Physiology, 2015
An understanding of the role of autophagic processes in the management of cardiac metabolic stress responses is advancing rapidly and progressing beyond a conceptualization of the autophagosome as a simple cell recycling depot. The importance of autophagy dysregulation in diabetic cardiomyopathy and in ischemic heart disease - both conditions ...
Lea M D, Delbridge, Kimberley M, Mellor, David J R, Taylor, Roberta A, Gottlieb   +3 more
openaire   +4 more sources