Atg45 is an autophagy receptor for glycogen, a non-preferred cargo of bulk autophagy in yeast [PDF]
iScienceSummary: The mechanisms governing autophagy of proteins and organelles have been well studied, but how other cytoplasmic components such as RNA and polysaccharides are degraded remains largely unknown.
Takahiro Isoda +4 more
doaj +2 more sources
Muscle glycogen unavailability and fat oxidation rate during exercise: Insights from McArdle disease [PDF]
The Journal of Physiology, Volume 601, Issue 3, Page 551-566, 1 February 2023., 2023 Glycogen store disease; Muscle fatigue; Substrate oxidationEnfermedad de almacenamiento de glucógeno; Fatiga muscular; Oxidación del sustratoMalaltia d'emmagatzematge de glucogen; Fatiga muscular; Oxidació del substratCarbohydrate availability affects ...
Real Martinez, Alberto +5 more
core +2 more sources
Gluconeogenesis and glycogenolysis required in metastatic breast cancer cells [PDF]
Frontiers in OncologyIntroductionMetabolic adaptability, including glucose metabolism, enables cells to survive multiple stressful environments. Glycogen may serve as a critical storage depot to provide a source of glucose during times of metabolic demand during the ...
Emily Hicks +12 more
doaj +2 more sources
Asiatic acid alleviates ischemic myocardial injury in mice by modulating mitophagy- and glycophagy-based energy metabolism. [PDF]
Acta Pharmacol Sin, 2022 Myocardial infarction (MI) causes disturbances in myocardial energy metabolism, ultimately leading to a poor prognosis. Cytosolic glycogen autophagy (glycophagy) and mitochondrial autophagy (mitophagy) are upregulated in MI to optimize energy metabolism but to a limited extent.
Qiu F +6 more
europepmc +3 more sources
Regulation of autophagy by plant‐based polyphenols: a critical review of current advances in glucolipid metabolic diseases and food industry applications [PDF]
Food Frontiers, Volume 4, Issue 3, Page 1039-1067, September 2023., 2023 Autophagy is a complex self-degrading process, and its imbalance adversely affects local (metabolically active organs) or systemic metabolism, resulting in metabolic dysfunction correlated with obesity, fatty liver, and type 2 diabetes.
Chen, J +7 more
core +2 more sources
Cargo hitchhiking autophagy - a hybrid autophagy pathway utilized in yeast. [PDF]
AutophagyMacroautophagy is a catabolic process that maintains cellular homeostasis by recycling intracellular material through the use of double-membrane vesicles called autophagosomes. In turn, autophagosomes fuse with vacuoles (in yeast and plants) or lysosomes
Cooper KF.
europepmc +3 more sources
Myocardial autophagic energy stress responses—macroautophagy, mitophagy, and glycophagy
American Journal of Physiology - Heart and Circulatory Physiology, 2015 An understanding of the role of autophagic processes in the management of cardiac metabolic stress responses is advancing rapidly and progressing beyond a conceptualization of the autophagosome as a simple cell recycling depot. The importance of autophagy dysregulation in diabetic cardiomyopathy and in ischemic heart disease - both conditions ...
Kimberley M Mellor, Roberta A Gottlieb
exaly +4 more sources
Glycogen Granules Are Degraded by Non-Selective Autophagy in Nitrogen-Starved Komagataella phaffii [PDF]
CellsAutophagy was initially recognized as a bulk degradation process that randomly sequesters and degrades cytoplasmic material in lysosomes (vacuoles in yeast). In recent years, various types of selective autophagy have been discovered.
Nimna V. Wijewantha +2 more
doaj +2 more sources
Autophagy of glycogen is non-selective in Komagataella phaffii [PDF]
Autophagy ReportsGlycogen is an important reserve polysaccharide from bacteria to human. It is organized in glycogen granules that also contain several proteins involved in their metabolism.
Taras Y. Nazarko
doaj +2 more sources
Journal of Molecular and Cellular Cardiology, 2013 Cardiac metabolic stress is a hallmark of many cardiac pathologies, including diabetes. Cardiac glycogen mis-handling is a frequent manifestation of various cardiopathologies. Diabetic females have a higher risk of heart disease than males, yet sex disparities in cardiac metabolic stress settings are not well understood.
Reichelt, M. E. +4 more
exaly +4 more sources