Results 21 to 30 of about 401 (96)

STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma

Cell Reports
Summary: The accumulation of lipid droplets (LDs) and glycogen is a major hallmark of clear cell renal cell carcinoma (ccRCC), yet their interplay remains unclear.
Hao Wang, Tong Xiao, Hao Zhuang, Yi Liu, Kexing Jin, Jing Li, Jun Li, Yan Gao, Dan Yue, Wei Cui, Qingxia Xu, Jingxuan Pan, Kangdong Liu, Yong Wang, Ruibing Chen, Hongle Li   +15 more
doaj   +2 more sources

Biomedical Implications of Autophagy in Macromolecule Storage Disorders [PDF]

Frontiers in Cell and Developmental Biology, 2019
An imbalance between the production and clearance of macromolecules such as proteins, lipids and carbohydrates can lead to a category of diseases broadly known as macromolecule storage disorders.
Adina Maria Palhegyi, Elena Seranova, Simona Dimova, Sheabul Hoque, Sovan Sarkar   +4 more
doaj   +2 more sources

Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity. [PDF]

J Cereb Blood Flow Metab, 2021
Autophagy is essential to cell function, as it enables the recycling of intracellular constituents during starvation and in addition functions as a quality control mechanism by eliminating spent organelles and proteins that could cause cellular damage if
Napoli E, Panoutsopoulos AA, Kysar P, Satriya N, Sterling K, Shibata B, Imai D, Ruskin DN, Zarbalis KS, Giulivi C.   +9 more
europepmc   +3 more sources

Osteocalcin modulates hippocampal activities and influences glycophagy within astrocytes in a chronic unpredictable mild stress mouse model [PDF]

Comprehensive Psychoneuroendocrinology
Chen H, Mao J, Wang M, Zhang Q, Zheng R, Wu Y, Ma X, Liu Q.   +7 more
exaly   +2 more sources

Regulation of autophagy by plant‐based polyphenols: A critical review of current advances in glucolipid metabolic diseases and food industry applications

Food Frontiers, Volume 4, Issue 3, Page 1039-1067, September 2023., 2023
Polyphenol‐mediated metabolic functions of autophagy occur in various tissues. Multiple signaling pathways, receptors, and transcription factors are involved. Polyphenol‐regulated autophagy benefits its application in the food industry. Abstract Autophagy is a complex self‐degrading process, and its imbalance adversely affects local (metabolically ...
Zhenyu Wang, Wei Quan, Maomao Zeng, Zhaojun Wang, Qiuming Chen, Jie Chen, Mark Christian, Zhiyong He   +7 more
wiley   +1 more source

A putative adverse outcome network for neonatal mortality and lower birth weight in rodents: Applicability to per‐ and polyfluoroalkyl substances and relevance to human health

Birth Defects Research, Volume 115, Issue 11, Page 1011-1062, June 15, 2023., 2023
Abstract Background Some per‐ and poly‐fluoroalkyl substances (PFAS) cause neonatal mortality and lower birth weight in rodents. We constructed an Adverse Outcome Pathway (AOP) network for neonatal mortality and lower birth weight in rodents, comprising three putative AOPs.
John M. Rogers, Melissa M. Heintz, Chad M. Thompson, Laurie C. Haws   +3 more
wiley   +1 more source

Muscle glycogen unavailability and fat oxidation rate during exercise: Insights from McArdle disease

The Journal of Physiology, Volume 601, Issue 3, Page 551-566, 1 February 2023., 2023
Abstract figure legend McArdle disease is caused by inherited blockade of glycogen breakdown in skeletal muscle fibres, with subsequent intolerance to most exercise tasks, as well as a substantial impairment of peak aerobic capacity. The present study indicates that the exercise capacity of these patients is mainly sustained by fat oxidation, with ...
Carlos Rodriguez‐Lopez, Alfredo Santalla, Pedro. L Valenzuela, Alberto Real‐Martínez, Mónica Villarreal‐Salazar, Irene Rodriguez‐Gomez, Tomàs Pinós, Ignacio Ara, Alejandro Lucia   +8 more
wiley   +1 more source

Lysosomal glycogen accumulation in Pompe disease results in disturbed cytoplasmic glycogen metabolism

Journal of Inherited Metabolic Disease, Volume 46, Issue 1, Page 101-115, January 2023., 2023
Abstract Pompe disease is an inherited metabolic myopathy caused by deficiency of acid alpha‐glucosidase (GAA), resulting in lysosomal glycogen accumulation. Residual GAA enzyme activity affects disease onset and severity, although other factors, including dysregulation of cytoplasmic glycogen metabolism, are suspected to modulate the disease course ...
Rodrigo Canibano‐Fraile, Laurike Harlaar, Carlos A. dos Santos, Marianne Hoogeveen‐Westerveld, Jeroen A. A. Demmers, Tim Snijders, Philip Lijnzaad, Robert M. Verdijk, Nadine A. M. E. van der Beek, Pieter A. van Doorn, Ans T. van der Ploeg, Esther Brusse, W. W. M. Pim Pijnappel, Gerben J. Schaaf   +13 more
wiley   +1 more source

Role of autophagy in aging: The good, the bad, and the ugly

Aging Cell, Volume 22, Issue 1, January 2023., 2023
Various forms of autophagy. Major types of autophagy include macroautophagy, microautophagy (inside the circle), and chaperone‐mediated autophagy. Autophagy is used for the removal of damaged biomolecules and organelles (outside the circle). Abstract Autophagy (self‐eating) is a conserved catabolic homeostatic process required for cellular metabolic ...
Siamak Tabibzadeh
wiley   +1 more source

Autophagy in health and disease: From molecular mechanisms to therapeutic target

MedComm, Volume 3, Issue 3, September 2022., 2022
Macroautophagy/autophagy is an evolutionally conserved catabolic process induced under various stress conditions to maintain intracellular homeostasis. Dysregulation of autophagy is closely associated with various human diseases. This review will focus on the molecular mechanisms in control of autophagy, the implication of autophagy in various human ...
Guang Lu, Yu Wang, Yin Shi, Zhe Zhang, Canhua Huang, Weifeng He, Chuang Wang, Han‐Ming Shen   +7 more
wiley   +1 more source