Results 41 to 50 of about 576 (126)

A guide to the regulation of selective autophagy receptors

The FEBS Journal, Volume 289, Issue 1, Page 75-89, January 2022., 2022
Selective autophagy receptors are essential for bridging the cellular cargo destined for degradation with autophagy machinery. As such, their role in autophagy is strictly regulated. In this review, we outline and discuss post‐translational (phosphorylation, ubiquitination, acetylation) and structural (oligomerisation) modifications involved in ...
Andrea Gubas, Ivan Dikic
wiley   +1 more source

Selective autophagy

Cancer Science, Volume 112, Issue 10, Page 3972-3978, October 2021., 2021
In this short review, we focus on the mechanism of "selective" autophagy, which is rapidly being elucidated. Abstract While starvation‐induced autophagy is thought to randomly degrade cellular components, under certain circumstances autophagy selectively recognizes, sequesters, and degrades specific targets via autophagosomes.
Mohammad Omar Faruk, Yoshinobu Ichimura, Masaaki Komatsu   +2 more
wiley   +1 more source

A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Lipids are integral cellular components that act as substrates for energy provision, signaling molecules, and essential constituents of biological membranes along with a variety of other biological functions. Despite their significance, lipid accumulation may result in lipotoxicity, impair autophagy, and lysosomal function that may lead to certain ...
Muhammad Babar Khawar, Muddasir Hassan Abbasi, Mussarat Rafiq, Naila Naz, Rabia Mehmood, Nadeem Sheikh, Carla Tatone   +6 more
wiley   +1 more source

Lafora disease offers a unique window into neuronal glycogen metabolism [PDF]

, 2018
Lafora disease (LD) is a fatal, autosomal recessive, glycogen-storage disorder that manifests as severe epilepsy. LD results from mutations in the gene encoding either the glycogen phosphatase laforin or the E3 ubiquitin ligase malin. Individuals with LD
Gentry, Matthew S., Guinovart, Joan J., Minassian, Berge A., Roach, Peter J., Serratosa, Jose M.   +4 more
core   +2 more sources

HOIL-1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation [PDF]

, 2022
HOIL‐1, a component of the linear ubiquitin chain assembly complex (LUBAC), ubiquitylates serine and threonine residues in proteins by esterification. Here, we report that mice expressing an E3 ligase‐inactive HOIL‐1[C458S] mutant accumulate polyglucosan
Cohen, Philip, Kelsall, Ian R, Knebel, Axel, Mancebo-Gamella, Paula, Matthews, Stephen J, McCrory, Elisha H, Nanda, Sambit K, Scudamore, Cheryl L, Wood, Nicola T, Xu, Yingqi   +9 more
core   +2 more sources

Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy [PDF]

, 2013
Several myopathies are associated with defects in autophagic and lysosomal degradation of glycogen, but it remains unclear how glycogen is targeted to the lysosome and what significance this process has for muscle cells.
Nieuwenhuis, Joppe, Perrimon, Norbert, Zirin, Jonathan   +2 more
core   +3 more sources

WDFY3 mutation alters laminar position and morphology of cortical neurons [PDF]

, 2022
Background: Proper cerebral cortical development depends on the tightly orchestrated migration of newly born neurons from the inner ventricular and subventricular zones to the outer cortical plate.
Cannizzaro, Noemi, Green, Ralph, Hippenmeyer, Simon, Rülicke, Thomas, Schaaf, Zachary A., Tat, Lyvin, Zarbalis, Konstantinos S.   +6 more
core   +1 more source

Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. [PDF]

, 2019
Biological roles of obscurin and its close homolog Obsl1 (obscurin-like 1) have been enigmatic. While obscurin is highly expressed in striated muscles, Obsl1 is found ubiquitously.
Blondelle, Jordan, Bremner, Shannon, Clark, Madison, Desmond, Patrick, Estève, Eric, Ghassemian, Majid, Lange, Stephan, Marrocco, Valeria, Myers, Stephanie, Nguyen, Jim, Pierantozzi, Enrico, Sorrentino, Vincenzo, Ward, Samuel, Wright, Matthew   +13 more
core   +5 more sources

Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation

Cell Reports, 2019
Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases.
Alicia Mayeuf-Louchart, Steve Lancel, Yasmine Sebti, Benoit Pourcet, Anne Loyens, Stéphane Delhaye, Christian Duhem, Justine Beauchamp, Lise Ferri, Quentin Thorel, Alexis Boulinguiez, Mathilde Zecchin, Julie Dubois-Chevalier, Jérôme Eeckhoute, Logan T. Vaughn, Peter J. Roach, Christian Dani, Bartholomew A. Pederson, Stéphane D. Vincent, Bart Staels, Hélène Duez   +20 more
doaj   +1 more source

Glycogen and its metabolism: some new developments and old themes [PDF]

, 2012
Glycogen is a branched polymer of glucose that acts as a store of energy in times of nutritional sufficiency for utilization in times of need. Its metabolism has been the subject of extensive investigation and much is known about its regulation by ...
Depaoli-Roach, Anna A., Hurley, Thomas D., Roach, Peter J., Tagliabracci, Vincent S.   +3 more
core   +1 more source