Results 41 to 50 of about 473 (103)

Role of autophagy in aging: The good, the bad, and the ugly

Aging Cell, Volume 22, Issue 1, January 2023., 2023
Various forms of autophagy. Major types of autophagy include macroautophagy, microautophagy (inside the circle), and chaperone‐mediated autophagy. Autophagy is used for the removal of damaged biomolecules and organelles (outside the circle). Abstract Autophagy (self‐eating) is a conserved catabolic homeostatic process required for cellular metabolic ...
Siamak Tabibzadeh
wiley   +1 more source

Autophagy in health and disease: From molecular mechanisms to therapeutic target

MedComm, Volume 3, Issue 3, September 2022., 2022
Macroautophagy/autophagy is an evolutionally conserved catabolic process induced under various stress conditions to maintain intracellular homeostasis. Dysregulation of autophagy is closely associated with various human diseases. This review will focus on the molecular mechanisms in control of autophagy, the implication of autophagy in various human ...
Guang Lu, Yu Wang, Yin Shi, Zhe Zhang, Canhua Huang, Weifeng He, Chuang Wang, Han‐Ming Shen   +7 more
wiley   +1 more source

A chromosome‐level genome of Antechinus flavipes provides a reference for an Australian marsupial genus with male death after mating

Molecular Ecology Resources, Volume 22, Issue 2, Page 740-754, February 2022., 2022
Abstract The 15 species of small carnivorous marsupials that comprise the genus Antechinus exhibit semelparity, a rare life‐history strategy in mammals where synchronized death occurs after one breeding season. Antechinus males, but not females, age rapidly (demonstrate organismal senescence) during the breeding season and show promise as new animal ...
Ran Tian, Kai Han, Yuepan Geng, Chen Yang, Chengcheng Shi, Patrick B. Thomas, Coral Pearce, Kate Moffatt, Siming Ma, Shixia Xu, Guang Yang, Xuming Zhou, Vadim N. Gladyshev, Xin Liu, Diana O. Fisher, Lisa K. Chopin, Natália O. Leiner, Andrew M. Baker, Guangyi Fan, Inge Seim   +19 more
wiley   +1 more source

A guide to the regulation of selective autophagy receptors

The FEBS Journal, Volume 289, Issue 1, Page 75-89, January 2022., 2022
Selective autophagy receptors are essential for bridging the cellular cargo destined for degradation with autophagy machinery. As such, their role in autophagy is strictly regulated. In this review, we outline and discuss post‐translational (phosphorylation, ubiquitination, acetylation) and structural (oligomerisation) modifications involved in ...
Andrea Gubas, Ivan Dikic
wiley   +1 more source

Regulation and role of glycophagy in skeletal muscle energy metabolism

, 2021
Glycophagy is the autophagic degradation of glycogen via the lysosomal enzyme GAA/alpha-acid glucosidase. Glycophagy is considered a housekeeping process to degrade poorly branched glycogen particles, but the regulation and role of glycophagy in skeletal
Timothy D. Heden (3710056), Curtis C. Hughey (3686770), Lisa S. Chow (5597075), Douglas G. Mashek (8467239)   +3 more
core   +1 more source

Selective autophagy

Cancer Science, Volume 112, Issue 10, Page 3972-3978, October 2021., 2021
In this short review, we focus on the mechanism of "selective" autophagy, which is rapidly being elucidated. Abstract While starvation‐induced autophagy is thought to randomly degrade cellular components, under certain circumstances autophagy selectively recognizes, sequesters, and degrades specific targets via autophagosomes.
Mohammad Omar Faruk, Yoshinobu Ichimura, Masaaki Komatsu   +2 more
wiley   +1 more source

A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Lipids are integral cellular components that act as substrates for energy provision, signaling molecules, and essential constituents of biological membranes along with a variety of other biological functions. Despite their significance, lipid accumulation may result in lipotoxicity, impair autophagy, and lysosomal function that may lead to certain ...
Muhammad Babar Khawar, Muddasir Hassan Abbasi, Mussarat Rafiq, Naila Naz, Rabia Mehmood, Nadeem Sheikh, Carla Tatone   +6 more
wiley   +1 more source

Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets. [PDF]

MedComm (2020)
Astrocytes display heterogeneity in various neurological disorders and behavioral neuropsychiatric disorders. Astrocytes influence the progression of neurological diseases through neuroinflammation, oxidative stress, metabolic abnormalities, intercellular interactions, and a spectrum of other pathophysiological processes.
Mao S, Qiao R, Wang Q, Shen L, Li D, Huo X, Wang J, Liu K, Chen W, Zhu T, Zhang B, Leng S, Bai Y.   +12 more
europepmc   +2 more sources

Selective autophagy in hepatocellular carcinoma: Mechanisms, roles and therapeutic implications (Review). [PDF]

Exp Ther Med
Selective autophagy, which is the targeted degradation of specific cellular components through lysosomes, serves a complex role in hepatocellular carcinoma (HCC).
Hsieh CH.
europepmc   +2 more sources

Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act

Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated primarily from endogenous biochemical reactions in mitochondria, endoplasmic reticulum (ER), and peroxisomes. Typically, ROS/RNS correlate with oxidative damage and cell death; however, free radicals are also crucial for normal cellular functions, including supporting ...
Natalia Jimenez-Moreno, Jon D. Lane, Claudio De Lucia   +2 more
wiley   +1 more source