Adapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in Melanoma [PDF]
, 2016 Melanoma has emerged as a paradigm of a highly aggressive and plastic cancer, capable to co-opt the tumour stroma in order to adapt to the hostile microenvironment, suppress immunosurveillance mechanisms and disseminate.
Hannelore Maes +3 more
core +2 more sources
Crosstalk between Glycogen-Selective Autophagy, Autophagy and Apoptosis as a Road towards Modifier Gene Discovery and New Therapeutic Strategies for Glycogen Storage Diseases [PDF]
, 2022 Glycogen storage diseases (GSDs) are rare metabolic monogenic disorders characterized by an excessive accumulation of glycogen in the cell. However, monogenic disorders are not simple regarding genotype-phenotype correlation.
Anđelković, Marina +6 more
core +1 more source
Dynamic glucose uptake, storage, and release by human microvascular endothelial cells [PDF]
, 2022 Endothelia determine blood-to-tissue solute delivery, yet glucose transit is poorly understood. To illuminate mechanisms, we tracked [3H]-2-deoxyglucose (2-DG) in human adipose-tissue microvascular endothelial cells.
Bilan, Philip J. +8 more
core +1 more source
Autophagy in healthy aging and disease [PDF]
, 2021 Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival.
Aman, Y +14 more
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Additional Pathogenic Pathways in RBCK1 Deficiency [PDF]
, 2022 RBCK1 deficiency is a rare congenital autoinflammatory disease that causes inflammatory disruption on the molecular level. This deficiency has three major clinical manifestations: increased sensitivity to bacterial infections, autoinflammation syndrome ...
Bolkov, M. A. +3 more
core +1 more source
Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act
Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020 Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated primarily from endogenous biochemical reactions in mitochondria, endoplasmic reticulum (ER), and peroxisomes. Typically, ROS/RNS correlate with oxidative damage and cell death; however, free radicals are also crucial for normal cellular functions, including supporting ...
Natalia Jimenez-Moreno +2 more
wiley +1 more source
The “sweet” side of ER-mitochondria contact sites
Communicative & Integrative Biology, 2017 The regions at which the ER and mitochondria come into close proximity, known as ER-mitochondria contact sites provide essential platforms for the exchange of molecules between the two organelles and the coordination of various fundamental cellular ...
Anthi Demetriadou +2 more
doaj +1 more source
Loss of autophagy in chondrocytes causes severe growth retardation [PDF]
, 2019 新潟大学博士(医学)Chondrogenesis is accompanied by not only cellular renovation, but also metabolic stress. Therefore, macroautophagy/autophagy is postulated to be involved in this process.
177874, Horigome, Yoji
core +1 more source
Investigation of the role of the glucose-6-phosphate translocase in the activation of autophagy and glycogen-selective autophagy in glycogen storage disease type IB patients [PDF]
, 2023 Introduction: Glycogen storage disease type Ib (GSD-Ib) is characterized by a deficiency of glucose-6- phosphate translocase (G6PT) encoded by the SLC37A4 gene, affecting glucose homeostasis and disrupting autophagy.
Anđelković, Marina +11 more
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Role of autophagy in the control of food intake [PDF]
, 2015 Treballs Finals de Grau de Farmàcia, Facultat de Farmàcia, Universitat de Barcelona, 2015. Tutora: Dolors Serra i Cucurull.[eng] Autophagy is an intracellular pathway which has been well characterised since many years ago. It is present in all cell types
Balañá García-Vela, Blanca
core