Results 51 to 60 of about 473 (103)

Investigation of the role of the glucose-6-phosphate translocase in the activation of autophagy and glycogen-selective autophagy in glycogen storage disease type IB patients [PDF]

, 2023
Introduction: Glycogen storage disease type Ib (GSD-Ib) is characterized by a deficiency of glucose-6- phosphate translocase (G6PT) encoded by the SLC37A4 gene, affecting glucose homeostasis and disrupting autophagy.
Jocić, Nikola, Anđelković, Marina, Parezanović, Marina, Ugrin, Milena, Klaassen, Kristel, Spasovski, Vesna, Stevanović, Nina, Skakić, Anita, Pavlović, Sonja, Stojiljković, Maja, Komazec, Jovana, Stanković, Sara   +11 more
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Uncovering the Role of Glycogen in Brown Adipose Tissue

, 2021
International audienceThe presence of glycogen in the brown adipose tissue (BAT) has been described 60 years ago. However, the role of this energetic storage in brown adipocytes has been long time underestimated.
Mayeuf-Louchart, Alicia
core   +1 more source

THE ROLE OF GLYCOGEN ACCUMULATION AND UTILIZATION IN METASTTIC BREAST CANCER PROGRESSION

, 2022
   Breast cancer is a significant public health concern being the second leading cause of cancer-related death in women, with a projected 43,250 deaths in the US in 2022.
Emily Michele Hicks (14221748)
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Immune modulation through secretory autophagy

Journal of Cellular Biochemistry, Volume 125, Issue 11, November 2024.
Abstract Autophagy is a central mechanism of cellular homeostasis through the degradation of a wide range of cellular constituents. However, recent evidence suggests that autophagy actively provides information to neighboring cells via a process called secretory autophagy. Secretory autophagy couples the autophagy machinery to the secretion of cellular
Andreas Weigert, Lina Herhaus
wiley   +1 more source

Advances in natural products modulating autophagy influenced by cellular stress conditions and their anticancer roles in the treatment of ovarian cancer

The FASEB Journal, Volume 38, Issue 19, 15 October 2024.
Natural products can influence various intracellular stress responses, thereby controlling the malignant biological behavior of ovarian cancer and affecting its progression. Abstract Autophagy is a conservative catabolic process that typically serves a cell‐protective function.
Dongxiao Li, Danbo Geng, Min Wang
wiley   +1 more source

The glycogenolytic enzyme acid α‐glucosidase is expressed in the bovine uterine endometrium

Reproduction in Domestic Animals, Volume 59, Issue 6, June 2024.
Abstract Progesterone has been shown to stimulate glycogen catabolism in uterine epithelial cells. Acid α‐glucosidase (GAA) is an enzyme that breaks down glycogen within lysosomes. We hypothesized that progesterone may stimulate glycogenolysis in the uterine epithelium via GAA.
Malia D. Berg, Matthew Dean
wiley   +1 more source

Molecular mechanisms of the cardiac glycogen response to physiological metabolic stress

, 2021
Full Text is available to authenticated members of The University of Auckland only.Background: The heart relies mainly on the oxidation of fatty acids and glucose for energy production, stored in the heart as triglycerides and glycogen respectively ...
James, Samuel
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Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib

Molecular Metabolism
Objective: Carbohydrate Response Element Binding Protein (ChREBP) is a glucose 6-phosphate (G6P)-sensitive transcription factor that acts as a metabolic switch to maintain intracellular glucose and phosphate homeostasis.
K.A. Krishnamurthy, M.G.S. Rutten, J.A. Hoogerland, T.H. van Dijk, T. Bos, M. Koehorst, M.P. de Vries, N.J. Kloosterhuis, H. Havinga, B.V. Schomakers, M. van Weeghel, J.C. Wolters, B.M. Bakker, M.H. Oosterveer   +13 more
doaj   +1 more source

Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1

, 2011
Glycogen, a branched polymer of glucose, acts as an intracellular carbon and energy reserve in many tissues and cell types. An important pathway for its degradation is by transport to lysosomes in an autophagy-like process.
Sixin Jiang, Clark D. Wells, Wells, Clark D., Jiang, Sixin, Peter J. Roach, Roach, Peter J.   +5 more
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Novel mechanisms of diastolic dysfunction in diabetes

, 2019
Diabetic cardiomyopathy is primarily characterised by diastolic dysfunction and deranged cardiomyocyte performance. The underlying mechanisms are unknown, and specific treatment targets are lacking.
Koutsifeli, Parisa
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