GABARAPL1 Inhibits EMT Signaling through SMAD-Tageted Negative Feedback [PDF]
Biology, 2021 The pathway of selective autophagy, leading to a targeted elimination of specific intracellular components, is mediated by the ATG8 proteins, and has been previously suggested to be involved in the regulation of the Epithelial–mesenchymal transition (EMT)
Eric Hervouet +2 more
exaly +5 more sources
Secretion of pro‐angiogenic extracellular vesicles during hypoxia is dependent on the autophagy‐related protein GABARAPL1 [PDF]
Journal of Extracellular Vesicles, 2021 Tumour hypoxia is a hallmark of solid tumours and contributes to tumour progression, metastasis development and therapy resistance. In response to hypoxia, tumour cells secrete pro‐angiogenic factors to induce blood vessel formation and restore oxygen ...
Joel Beaumont +2 more
exaly +7 more sources
Molecular Oncology, 2022 Cancer stem‐like cells (CSLC) are considered a major contributor to the development and progression of hepatocellular carcinoma (HCC). Previous studies indicated that CSLC are characterized by resistance to ferroptosis, a type of lipid peroxidation ...
Xiao-Jing Du, xingxing zhang, Zhijie Yu
exaly +4 more sources
GABARAPL1 Promotes AR+ Prostate Cancer Growth by Increasing FL-AR/AR-V Transcription Activity and Nuclear Translocation [PDF]
Frontiers in Oncology, 2019 The next generation Androgen receptor (AR)-targeted therapies are now in widespread clinical use and prolong prostate cancer (CaP) patient survival. However, the therapies are not curative due to diverse range of resistance mechanisms. AR variants (AR-V),
Bing Su, Xiaofan Chen
exaly +6 more sources
GABARAPL1 is important for the activation of HRI during eIF2α phosphorylation-dependent stress response to sodium arsenite [PDF]
Scientific ReportsSodium arsenite is known to activate the integrated stress response pathway, through the activation of the heme-regulated inhibitor kinase (HRI). Upon activation, HRI phosphorylates the α subunit of the translation initiation factor eIF2, resulting in ...
Sarah Campenet +8 more
doaj +2 more sources
Identification of mitophagy-related genes in patients with acute myocardial infarction [PDF]
HereditasMitophagy is involved in acute myocardial infarction (AMI) process. However, the role of mitophagy-related genes (MRGs) in the AMI process is not well illustrated. We identified MRGs involved in AMI by bioinformatics analysis.
Ju-Ying Li +7 more
doaj +2 more sources
Prognostic implications of autophagy and pyroptosis related genes in oral squamous cell carcinoma: research on bioinformatics and experiments [PDF]
Frontiers in OncologyObjectiveOral squamous cell carcinoma (OSCC) is associated with poor prognosis, underscoring the urgent need to identify biomarkers that can predict patient outcomes and guide personalized treatment strategies.
Leshui Qiao +3 more
doaj +2 more sources
Glycophagy: molecular mechanisms, regulatory signals, and disease associations [PDF]
Autophagy ReportsGlycophagy is a process of selective degradation of glycogen through the autophagy pathway. It relies on key proteins, such as STBD1 (glycogen-specific autophagy receptor), GABARAPL1 (member of the ATG8 family), and acid α-glucosidase (GAA), and proceeds
Lei Chen +3 more
doaj +2 more sources
Identification of autophagy-related genes in intestinal ischemia-reperfusion injury and their role in immune infiltration [PDF]
Frontiers in PhysiologyBackgroundIntestinal ischemia-reperfusion (II/R) injury is a serious condition characterized by high morbidity and mortality rates. Research has shown that II/R injury is closely linked to autophagy and immune dysregulation.
Yichen Hu +8 more
doaj +2 more sources
Methods for detection of cardiac glycogen-autophagy [PDF]
Autophagy ReportsGlycogen-autophagy (‘glycophagy’) is a selective autophagy process involved in delivering glycogen to the lysosome for bulk degradation. Glycophagy protein intermediaries include STBD1 as a glycogen tagging receptor, delivering the glycogen cargo into ...
Parisa Koutsifeli +14 more
doaj +2 more sources