GABARAPL1 Inhibits EMT Signaling through SMAD-Tageted Negative Feedback [PDF]
Biology, 2021 The pathway of selective autophagy, leading to a targeted elimination of specific intracellular components, is mediated by the ATG8 proteins, and has been previously suggested to be involved in the regulation of the Epithelial–mesenchymal transition (EMT)
Eric Hervouet +2 more
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Secretion of pro‐angiogenic extracellular vesicles during hypoxia is dependent on the autophagy‐related protein GABARAPL1 [PDF]
Journal of Extracellular Vesicles, 2021 Tumour hypoxia is a hallmark of solid tumours and contributes to tumour progression, metastasis development and therapy resistance. In response to hypoxia, tumour cells secrete pro‐angiogenic factors to induce blood vessel formation and restore oxygen ...
Tom G Keulers +2 more
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The Small Molecule H89 Facilitates Mesenchymal Stem Cell‐derived Extracellular Vesicle Release and Optimizes Therapeutic Efficacy in Liver Regeneration [PDF]
Journal of Extracellular VesiclesThe role of human umbilical cord mesenchymal stem cell‐derived extracellular vesicles (hUCMSC‐EVs) in liver regeneration is promising, yet their clinical translation is hampered by insufficient production. Current strategies targeting their secretion are
Yu Fu +14 more
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Molecular Oncology, 2022 Cancer stem‐like cells (CSLC) are considered a major contributor to the development and progression of hepatocellular carcinoma (HCC). Previous studies indicated that CSLC are characterized by resistance to ferroptosis, a type of lipid peroxidation ...
Xiaojing Du, Zhuoran Qi, Jinzhi Xu
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GABARAPL1 is important for the activation of HRI during eIF2α phosphorylation-dependent stress response to sodium arsenite [PDF]
Scientific ReportsSodium arsenite is known to activate the integrated stress response pathway, through the activation of the heme-regulated inhibitor kinase (HRI). Upon activation, HRI phosphorylates the α subunit of the translation initiation factor eIF2, resulting in ...
Sarah Campenet +8 more
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GABARAPL1 is essential for ACR-induced autophagic cell death of mouse Leydig cells
Ecotoxicology and Environmental SafetyAcrylamide (ACR), a chemical extensively utilized in industry and food processing sectors, has been recognized for its potentially irreversible adverse effect on male reproductive system; however, the underlying mechanism remains elusive.
Linlin Xu +2 more
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Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1. [PDF]
PLoS ONE, 2013 Macroautophagy is a highly conserved cellular degradation process, regulated by autophagy-related (atg) factors, in which a double membrane autophagosome engulfs cytoplasmic components to target them for degradation.
Jaclyn Nicole Le Grand +7 more
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The NMD Pathway Regulates GABARAPL1 mRNA during the EMT [PDF]
Biomedicines, 2021 EMT is a reversible cellular process that is linked to gene expression reprogramming, which allows for epithelial cells to undergo a phenotypic switch to acquire mesenchymal properties.
Timothée Baudu +12 more
doaj +6 more sources
Inhibition of GABARAP or GABARAPL1 prevents aminoglycoside- induced hearing loss [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaAminoglycosides (AGs) are highly potent, broad-spectrum antibiotics frequently used as first-line treatments for multiple life-threatening infections. Despite their severe ototoxicity, causing irreversible hearing loss in millions of people annually, no preventive therapy has been approved.
Jinan Li, Seung-Il Oh, Chang Liu
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Exploring exosome-related genes as candidate biomarkers in primary immune thrombocytopenia through transcriptomics and preliminary experimental validation [PDF]
Scientific ReportsPrimary Immune Thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia and bleeding tendency. Exosomes mediate abnormal crosstalk between immune cells and megakaryocytes in ITP, suggesting that exosome-related genes may serve as
Fangfang Lou +6 more
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