Secretion of pro‐angiogenic extracellular vesicles during hypoxia is dependent on the autophagy‐related protein GABARAPL1 [PDF]
Journal of Extracellular Vesicles, 2021 Tumour hypoxia is a hallmark of solid tumours and contributes to tumour progression, metastasis development and therapy resistance. In response to hypoxia, tumour cells secrete pro‐angiogenic factors to induce blood vessel formation and restore oxygen ...
Kasper Rouschop +2 more
exaly +11 more sources
GABARAPL1 is important for the activation of HRI during eIF2α phosphorylation-dependent stress response to sodium arsenite [PDF]
Scientific ReportsSodium arsenite is known to activate the integrated stress response pathway, through the activation of the heme-regulated inhibitor kinase (HRI). Upon activation, HRI phosphorylates the α subunit of the translation initiation factor eIF2, resulting in ...
Sarah Campenet +8 more
doaj +6 more sources
GABARAPL1 Inhibits EMT Signaling through SMAD-Tageted Negative Feedback [PDF]
Biology, 2021 The pathway of selective autophagy, leading to a targeted elimination of specific intracellular components, is mediated by the ATG8 proteins, and has been previously suggested to be involved in the regulation of the Epithelial–mesenchymal transition (EMT)
Aurélie Baguet +2 more
exaly +5 more sources
Frontiers in Oncology, 2019 The next generation Androgen receptor (AR)-targeted therapies are now in widespread clinical use and prolong prostate cancer (CaP) patient survival. However, the therapies are not curative due to diverse range of resistance mechanisms. AR variants (AR-V),
Bing Su, Xiaofan Chen
exaly +4 more sources
The Small Molecule H89 Facilitates Mesenchymal Stem Cell‐derived Extracellular Vesicle Release and Optimizes Therapeutic Efficacy in Liver Regeneration [PDF]
Journal of Extracellular VesiclesThe role of human umbilical cord mesenchymal stem cell‐derived extracellular vesicles (hUCMSC‐EVs) in liver regeneration is promising, yet their clinical translation is hampered by insufficient production. Current strategies targeting their secretion are
Yu Fu +14 more
doaj +3 more sources
Molecular Oncology, 2022 Cancer stem‐like cells (CSLC) are considered a major contributor to the development and progression of hepatocellular carcinoma (HCC). Previous studies indicated that CSLC are characterized by resistance to ferroptosis, a type of lipid peroxidation ...
Xingxing Zhang +2 more
exaly +4 more sources
Exploring exosome-related genes as candidate biomarkers in primary immune thrombocytopenia through transcriptomics and preliminary experimental validation [PDF]
Scientific ReportsPrimary Immune Thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia and bleeding tendency. Exosomes mediate abnormal crosstalk between immune cells and megakaryocytes in ITP, suggesting that exosome-related genes may serve as
Fangfang Lou +6 more
doaj +2 more sources
Ferroptosis-Based Peripheral Immune Dysregulation and Diagnostic Signatures in Parkinson's Disease: An RNA Transcriptomic and Single-Cell Immune Sequencing Analysis. [PDF]
FASEB JThis study explored the crosstalk between ferroptosis‐related genes and peripheral immune alterations in Parkinson's disease. We constructed a gene signature and classified molecular subtypes, and further pinpointed key ferroptosis‐associated molecules in immune cells and neuronal cells.
Cheng L +5 more
europepmc +2 more sources
Glycophagy: molecular mechanisms, regulatory signals, and disease associations [PDF]
Autophagy ReportsGlycophagy is a process of selective degradation of glycogen through the autophagy pathway. It relies on key proteins, such as STBD1 (glycogen-specific autophagy receptor), GABARAPL1 (member of the ATG8 family), and acid α-glucosidase (GAA), and proceeds
Lei Chen +3 more
doaj +2 more sources
Prognostic implications of autophagy and pyroptosis related genes in oral squamous cell carcinoma: research on bioinformatics and experiments [PDF]
Frontiers in OncologyObjectiveOral squamous cell carcinoma (OSCC) is associated with poor prognosis, underscoring the urgent need to identify biomarkers that can predict patient outcomes and guide personalized treatment strategies.
Leshui Qiao +3 more
doaj +2 more sources