GABARAPL1 is essential for ACR-induced autophagic cell death of mouse Leydig cells
Ecotoxicology and Environmental SafetyAcrylamide (ACR), a chemical extensively utilized in industry and food processing sectors, has been recognized for its potentially irreversible adverse effect on male reproductive system; however, the underlying mechanism remains elusive.
Jiaxiang Chen
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Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1. [PDF]
PLoS ONE, 2013 Macroautophagy is a highly conserved cellular degradation process, regulated by autophagy-related (atg) factors, in which a double membrane autophagosome engulfs cytoplasmic components to target them for degradation.
Jaclyn Nicole Le Grand +7 more
doaj +5 more sources
Inhibition of GABARAP or GABARAPL1 prevents aminoglycoside- induced hearing loss [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaAminoglycosides (AGs) are highly potent, broad-spectrum antibiotics frequently used as first-line treatments for multiple life-threatening infections. Despite their severe ototoxicity, causing irreversible hearing loss in millions of people annually, no ...
Seung-Il Oh, Bo Zhao, Chang Liu
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Scientific Reports, 2023 The ubiquitin‒proteasome system (UPS) and autophagy are the two primary cellular pathways of misfolded or damaged protein degradation that maintain cellular proteostasis.
Atsushi Hatanaka +9 more
doaj +4 more sources
The NMD Pathway Regulates GABARAPL1 mRNA during the EMT [PDF]
Biomedicines, 2021 EMT is a reversible cellular process that is linked to gene expression reprogramming, which allows for epithelial cells to undergo a phenotypic switch to acquire mesenchymal properties.
Timothée Baudu +12 more
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GABARAPL1 is essential in extracellular vesicle cargo loading and metastasis development [PDF]
Radiotherapy and OncologyBackground and purpose: Hypoxia is a common feature of tumours, associated with poor prognosis due to increased resistance to radio- and chemotherapy and enhanced metastasis development.
Barbeau, Lydie M.O.; id_orcid +10 more
core +7 more sources
PLoS Pathogens, 2023 Recently, viruses have been shown to regulate selective autophagy for productive infections. For instance, human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), activates selective autophagy of mitochondria, termed ...
Mai Tram Vo +2 more
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GABARAPL1 suppresses metastasis by counteracting PI3K/Akt pathway in prostate cancer
Oncotarget, 2017 Metastasis remains the primary cause of prostate cancer (CaP)-related death. Using a genome wide shRNA screen, we identified GABARAPL1 as a potential CaP metastasis suppressor.
Chen, Xiaofan +6 more
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Targeting GABARAPL1/HIF-2a axis to induce tumor cell apoptosis in nasopharyngeal carcinoma [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): The primary gene mutations associated with nasopharyngeal carcinoma (NPC) are located within the phosphoinositide 3-kinase-mammalian target of rapamycin signaling pathways, which have inhibitory effects on autophagy.
Xiaopeng Huang +3 more
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GABARAPL1 Exerts Regulatory Effects on Hypoxia‐Induced Pyroptosis in the Pathogenesis of Myocardial Infarction [PDF]
Journal of Cellular and Molecular MedicineABSTRACTMyocardial infarction (MI) is a major health threat, with high incidence and poor prognosis. This study aims to discover novel biomarkers and therapeutic targets to reduce myocardial damage and improve patient survival. A comprehensive bioinformatics analysis of MI datasets was conducted to identify pivotal genes related to pyroptosis and ...
Yaling Han
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