Results 11 to 20 of about 2,771 (143)
Frontiers in Oncology, 2019 The next generation Androgen receptor (AR)-targeted therapies are now in widespread clinical use and prolong prostate cancer (CaP) patient survival. However, the therapies are not curative due to diverse range of resistance mechanisms. AR variants (AR-V),
Bing Su, Xiaofan Chen
exaly +3 more sources
GABARAPL1 Exerts Regulatory Effects on Hypoxia‐Induced Pyroptosis in the Pathogenesis of Myocardial Infarction [PDF]
Journal of Cellular and Molecular MedicineABSTRACTMyocardial infarction (MI) is a major health threat, with high incidence and poor prognosis. This study aims to discover novel biomarkers and therapeutic targets to reduce myocardial damage and improve patient survival. A comprehensive bioinformatics analysis of MI datasets was conducted to identify pivotal genes related to pyroptosis and ...
Chenghui Yan, Haixu Song, Yaling Han
exaly +4 more sources
Targeting GABARAPL1/HIF-2a axis to induce tumor cell apoptosis in nasopharyngeal carcinoma [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): The primary gene mutations associated with nasopharyngeal carcinoma (NPC) are located within the phosphoinositide 3-kinase-mammalian target of rapamycin signaling pathways, which have inhibitory effects on autophagy.
Xiaopeng Huang +3 more
doaj +3 more sources
Prognostic implications of autophagy and pyroptosis related genes in oral squamous cell carcinoma: research on bioinformatics and experiments [PDF]
Frontiers in OncologyObjectiveOral squamous cell carcinoma (OSCC) is associated with poor prognosis, underscoring the urgent need to identify biomarkers that can predict patient outcomes and guide personalized treatment strategies.
Leshui Qiao +3 more
doaj +2 more sources
Glycophagy: molecular mechanisms, regulatory signals, and disease associations [PDF]
Autophagy ReportsGlycophagy is a process of selective degradation of glycogen through the autophagy pathway. It relies on key proteins, such as STBD1 (glycogen-specific autophagy receptor), GABARAPL1 (member of the ATG8 family), and acid α-glucosidase (GAA), and proceeds
Lei Chen +3 more
doaj +2 more sources
Identification of mitophagy-related genes in patients with acute myocardial infarction [PDF]
HereditasMitophagy is involved in acute myocardial infarction (AMI) process. However, the role of mitophagy-related genes (MRGs) in the AMI process is not well illustrated. We identified MRGs involved in AMI by bioinformatics analysis.
Ju-Ying Li +7 more
doaj +2 more sources
Identification of autophagy-related genes in intestinal ischemia-reperfusion injury and their role in immune infiltration [PDF]
Frontiers in PhysiologyBackgroundIntestinal ischemia-reperfusion (II/R) injury is a serious condition characterized by high morbidity and mortality rates. Research has shown that II/R injury is closely linked to autophagy and immune dysregulation.
Yichen Hu +8 more
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Scientific Reports, 2023 The ubiquitin‒proteasome system (UPS) and autophagy are the two primary cellular pathways of misfolded or damaged protein degradation that maintain cellular proteostasis.
Atsushi Hatanaka +9 more
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Methods for detection of cardiac glycogen-autophagy [PDF]
Autophagy ReportsGlycogen-autophagy (‘glycophagy’) is a selective autophagy process involved in delivering glycogen to the lysosome for bulk degradation. Glycophagy protein intermediaries include STBD1 as a glycogen tagging receptor, delivering the glycogen cargo into ...
Parisa Koutsifeli +14 more
doaj +2 more sources
Cells, 2022 Vaccine therapy is a promising method of research to promote T cell immune response and to develop novel antitumor immunotherapy protocols. Accumulating evidence has shown that autophagy is involved in antigen processing and presentation to T cells.
Leïla Fonderflick +5 more
doaj +3 more sources