GABARAPL1 is essential for ACR-induced autophagic cell death of mouse Leydig cells
Ecotoxicology and Environmental SafetyAcrylamide (ACR), a chemical extensively utilized in industry and food processing sectors, has been recognized for its potentially irreversible adverse effect on male reproductive system; however, the underlying mechanism remains elusive.
Jiaxiang Chen
exaly +5 more sources
Inhibition of GABARAP or GABARAPL1 prevents aminoglycoside- induced hearing loss [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaAminoglycosides (AGs) are highly potent, broad-spectrum antibiotics frequently used as first-line treatments for multiple life-threatening infections. Despite their severe ototoxicity, causing irreversible hearing loss in millions of people annually, no preventive therapy has been approved.
Jinan Li, Seung-Il Oh, Chang Liu
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The NMD Pathway Regulates GABARAPL1 mRNA during the EMT [PDF]
Biomedicines, 2021 EMT is a reversible cellular process that is linked to gene expression reprogramming, which allows for epithelial cells to undergo a phenotypic switch to acquire mesenchymal properties.
Timothée Baudu +12 more
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Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1. [PDF]
PLoS ONE, 2013 Macroautophagy is a highly conserved cellular degradation process, regulated by autophagy-related (atg) factors, in which a double membrane autophagosome engulfs cytoplasmic components to target them for degradation.
Jaclyn Nicole Le Grand +7 more
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GABARAPL1 Exerts Regulatory Effects on Hypoxia‐Induced Pyroptosis in the Pathogenesis of Myocardial Infarction [PDF]
Journal of Cellular and Molecular MedicineABSTRACTMyocardial infarction (MI) is a major health threat, with high incidence and poor prognosis. This study aims to discover novel biomarkers and therapeutic targets to reduce myocardial damage and improve patient survival. A comprehensive bioinformatics analysis of MI datasets was conducted to identify pivotal genes related to pyroptosis and ...
Yaling Han
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Targeting GABARAPL1/HIF-2a axis to induce tumor cell apoptosis in nasopharyngeal carcinoma [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): The primary gene mutations associated with nasopharyngeal carcinoma (NPC) are located within the phosphoinositide 3-kinase-mammalian target of rapamycin signaling pathways, which have inhibitory effects on autophagy.
Xiaopeng Huang +3 more
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GABARAP proteins regulate the packaging of HIV-1 genomic RNA into virions [PDF]
EMBO ReportsIn addition to their role in canonical autophagy, autophagy proteins (ATG) contribute to various cellular processes, including phagocytosis, membrane remodeling, and vesicle secretion.
Marjory Palaric +9 more
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Scientific Reports, 2023 The ubiquitin‒proteasome system (UPS) and autophagy are the two primary cellular pathways of misfolded or damaged protein degradation that maintain cellular proteostasis.
Atsushi Hatanaka +9 more
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Cells, 2022 Vaccine therapy is a promising method of research to promote T cell immune response and to develop novel antitumor immunotherapy protocols. Accumulating evidence has shown that autophagy is involved in antigen processing and presentation to T cells.
Leïla Fonderflick +5 more
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Integrated Transcriptomic Analysis Identifies Immune Remodeling and Prognostic Signatures in Uveal Melanoma. [PDF]
Int J GenomicsBackground Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults and exhibits a high propensity for liver metastasis, often leading to poor prognosis. However, effective prognostic biomarkers and therapeutic strategies for metastatic UVM remain limited.
Li Z, Yang Y, Wang H, Wang J.
europepmc +2 more sources