Results 41 to 50 of about 2,771 (143)

Regulation of Autophagy in Chick Skeletal Muscle: Effect of mTOR Inhibition

The Journal of Poultry Science, 2020
Autophagy in the skeletal muscle increases under catabolic conditions resulting in muscle atrophy. This study investigated the effect of inhibition of mechanistic target of rapamycin (mTOR) on autophagy in chick skeletal muscle.
Kazuki Nakashima, Aiko Ishida
doaj   +1 more source

Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation

Cell Death and Disease, 2022
Channelling of glucose via glycogen, known as the glycogen shunt, may play an important role in the metabolism of brain tumours, especially in hypoxic conditions.
Christos E. Zois, Anne M. Hendriks, Syed Haider, Elisabete Pires, Esther Bridges, Dimitra Kalamida, Dimitrios Voukantsis, B. Christoffer Lagerholm, Rudolf S. N. Fehrmann, Wilfred F. A. den Dunnen, Andrei I. Tarasov, Otto Baba, John Morris, Francesca M. Buffa, James S. O. McCullagh, Mathilde Jalving, Adrian L. Harris   +16 more
doaj   +1 more source

An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

Cell Reports, 2023
Summary: The nucleolar scaffold protein NPM1 is a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants promoting its aberrant cytoplasmic localization, are the most frequent ...
Hannah Mende, Anshu Khatri, Carolin Lange, Sergio Alejandro Poveda-Cuevas, Georg Tascher, Adriana Covarrubias-Pinto, Frank Löhr, Sebastian E. Koschade, Ivan Dikic, Christian Münch, Anja Bremm, Lorenzo Brunetti, Christian H. Brandts, Hannah Uckelmann, Volker Dötsch, Vladimir V. Rogov, Ramachandra M. Bhaskara, Stefan Müller   +17 more
doaj   +1 more source

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources

Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation [PDF]

Journal of Cell Biology, 2018
Proteasome inhibitors are used as research tools and to treat multiple myeloma, and proteasome activity is diminished in several neurodegenerative diseases. We therefore studied how cells compensate for proteasome inhibition. In 4 h, proteasome inhibitor treatment caused dramatic and selective induction of GABARAPL1 (but not other autophagy genes) and ...
Zhe Sha, Helena M. Schnell, Kerstin Ruoff, Alfred Goldberg   +3 more
openaire   +2 more sources

Low expression of GABARAPL1 is associated with a poor outcome for patients with hepatocellular carcinoma

Oncology Reports, 2014
Autophagy is an evolutionarily conserved cellular process that degrades cytoplasmic materials through the lysosomal pathway. The deregulation of autophagy is associated with several diseases, particularly cancer. Hepatocellular carcinoma (HCC) is one of the most aggressive cancers with a poor prognosis.
Chao, Liu, Yan, Xia, Wei, Jiang, Yinkun, Liu, Long, Yu   +4 more
openaire   +3 more sources

MicroRNA-195 regulates proliferation, migration, angiogenesis and autophagy of endothelial progenitor cells by targeting GABARAPL1 [PDF]

Bioscience Reports, 2016
Deep vein thrombosis (DVT) is a common type of venous thrombosis. Successful resolution of DVT-related thrombi is important in the treatment of DVT. Endothelial progenitor cells (EPCs) have emerged as a promising therapeutic choice for DVT-related thrombus resolution; however, the clinical application of EPCs faces many challenges. In the present study,
Mo, Jianwen, Zhang, Daifen, Yang, Renze
openaire   +2 more sources

Histone lysine demethylase 3B regulates autophagy via transcriptional regulation of GABARAPL1 in acute myeloid leukemia cells

International Journal of Oncology, 2023
Macroautophagy (hereafter referred to as autophagy) is a highly conserved self‑digestion process that is critical for maintaining homeostasis in response to various stresses. The autophagy‑related protein family, including the GABA type A receptor‑associated protein (GABARAP) and microtubule‑associated protein 1 light chain 3 subfamilies, is crucial ...
Song, Ying, Zhang, Jiaqi, Wang, Haihua, Wang, Haiying, Liu, Yong, Hu, Zhenbo   +5 more
openaire   +2 more sources

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source