Insulin Inhibits Autophagy by Inhibiting the Binding of FoXO1 to the Promoter Region of GABARAPL1
Hormone and Metabolic Research, 2023 AbstractHyperinsulinemia and insulin resistance in T2D have a potent suppressive effect on hepatic autophagy, however, the underlying mechanisms remain unclear. To explore the effect of insulin on hepatic autophagy and its possible signaling pathways, HL-7702 cells were treated with insulin ...
Jie Wen +6 more
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PLoS Pathogens, 2022 Host-pathogen dynamics are constantly at play during enteroviral infection. Coxsackievirus B (CVB) is a common juvenile enterovirus that infects multiple organs and drives inflammatory diseases including acute pancreatitis and myocarditis.
Savannah Sawaged +10 more
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Mitochondrial dynamics and quality control in Huntington's disease [PDF]
, 2015 Huntington's disease (HD) is an inherited neurodegenerative disorder caused by polyglutamine expansion mutations in the huntingtin protein. Despite its ubiquitous distribution, expression of mutant huntingtin (mHtt) is particularly detrimental to medium ...
de Proença, J +5 more
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Induction of the expression of GABARAPL1 by hydrogen peroxide in C6 glioma cells [PDF]
Integrative Molecular Medicine, 2015 Ischemia-reperfusion or traumatic brain injury induces the accumulation of reactive oxygen species (ROS) in brain. ROS causes oxidative stress to astrocytes as well as neurons and oxidative stress induces the damage to organelles, proteins or lipids.
Hiromi Nochi +3 more
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PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors [PDF]
, 2015 Class I phosphatidylinositol 3-kinases (PI3Ks) are frequently activated in T-cell acute lymphoblastic leukemia (T-ALL), mainly due to the loss of PTEN function. Therefore, targeting PI3Ks is a promising innovative approach for T-ALL treatment, however at
Buontempo, Francesca +10 more
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Location, location, location: the evolutionary history of CD1 genes and the NKR-P1/ligand systems [PDF]
, 2016 CD1 genes encode cell surface molecules that present lipid antigens to various kinds of T lymphocytes of the immune system. The structures of CD1 genes and molecules are like the major histocompatibility complex (MHC) class I system, the loading of ...
Kaufman, Jim, Rogers, Sally L
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Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation [PDF]
Journal of Cell Biology, 2018 Proteasome inhibitors are used as research tools and to treat multiple myeloma, and proteasome activity is diminished in several neurodegenerative diseases. We therefore studied how cells compensate for proteasome inhibition. In 4 h, proteasome inhibitor treatment caused dramatic and selective induction of GABARAPL1 (but not other autophagy genes) and ...
Zhe Sha +3 more
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Potential function for the Huntingtin protein as a scaffold for selective autophagy [PDF]
, 2014 Although dominant gain-of-function triplet repeat expansions in the Huntingtin (HTT) gene are the underlying cause of Huntington disease (HD), understanding the normal functions of nonmutant HTT protein has remained a challenge.
Csikos, George +17 more
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The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy. [PDF]
, 2015 Autophagy plays a key role during Salmonella infection, by eliminating these pathogens following escape into the cytosol. In this process, selective autophagy receptors, including the myosin VI adaptor proteins optineurin and NDP52, have been shown to ...
Allen, Mark +6 more
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Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia [PDF]
, 2014 BACKGROUND: Evidence from cachectic cancer patients and animal models of cancer cachexia supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer-induced skeletal muscle wasting. However, the genome-wide gene networks and
Beharry, Adam W. +6 more
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