Results 61 to 70 of about 3,167 (176)
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska +4 more
wiley +1 more source
Mitophagy assays in control and GABARAPL1 KO HeLa.Kyoto cells co-transfected with V5-NIX, vIRF-1-Flag, or HA-GABARAPL1 WT and variants (VIRX, HPX, and G116A) along with the reporter mito-mCE. More than 50 cells per sample were counted.
Chang-Yong Choi (3597962) +2 more
core +1 more source
Methods for detection of cardiac glycogen-autophagy
Glycogen-autophagy (‘glycophagy’) is a selective autophagy process involved in delivering glycogen to the lysosome for bulk degradation. Glycophagy protein intermediaries include STBD1 as a glycogen tagging receptor, delivering the glycogen cargo into ...
Parisa Koutsifeli +14 more
doaj +1 more source
Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril +2 more
wiley +1 more source
GABARAPL1 expression in different neuronal populations.
Immunohistochemical analysis of WT mouse brain tissue with an anti-GABARAPL1 antibody and different neuronal population markers. Images represent double staining with anti-GABARAPL1 and either anti-choline acetyltransferase in the cerebellar cortex-CBX ...
Jianhua Zhang (6347) +7 more
core +1 more source
s: Skeletal muscles have a high demand for ATP, which is met largely through mitochondria oxidative phosphorylation. Autophagy is essential for the maintenance of skeletal muscle mass under catabolic conditions.
Kazuki Nakashima, Aiko Ishida
doaj +1 more source
Abstract figure legend Ten older healthy male adults underwent 10 days of bed rest. Vastus lateralis muscle biopsies were collected at baseline (PRE) and after 10 days of bed rest (BR10), and mitochondrial adaptations were assessed using an integrative approach combining respirometry, protein analyses, RNA sequencing and transmission electron ...
Evgeniia Motanova +16 more
wiley +1 more source
Silencing TBK1 increases the release of GABARAPL1 and GABARAPL2 in EVs.
(A) EV lysates from siSCRAMBLE and siTBK1 cells were analyzed by Western blot. Densitometric quantification of GABARAPL1 and GABARAPL2. *, p p p (TIF)
Roberta A. Gottlieb (8180970) +10 more
core +1 more source
Macroautophagy (hereafter referred to as autophagy) is a highly conserved self‑digestion process that is critical for maintaining homeostasis in response to various stresses. The autophagy‑related protein family, including the GABA type A receptor‑associated protein (GABARAP) and microtubule‑associated protein 1 light chain 3 subfamilies, is crucial ...
Song, Ying +5 more
openaire +2 more sources
Workflow for identifying HIF1A‐expression‐associated ferroptosis‐related candidate circulating biomarkers in diabetic nephropathy using whole‐blood GEO transcriptomic datasets, ferroptosis‐related gene screening, exploratory machine‐learning prioritization, external validation, RT‐qPCR validation, and estimated circulating immune‐cell composition ...
Yufeng Li +7 more
wiley +1 more source

