Results 61 to 70 of about 4,298 (193)

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors. [PDF]

, 2020
Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers.
Axelrod, Joshua, Bapat, Jaidev, Delaney, Joe R, DeStefano, John W, Haghighiabyaneh, Mina, Harismendy, Olivier, Jones, Christian M, La Spada, Albert R, Ortell, Katherine K, Patel, Chandni B, Ramos-Zapatero, Maria, Schlaepfer, David D, Stupack, Dwayne G, Tancioni, Isabelle, Tanios, Ralph   +14 more
core   +1 more source

[Retracted] Oxidative‐Damaged Mitochondria Activate GABARAPL1‐Induced NLRP3 Inflammasomes in an Autophagic‐Exosome Manner after Acute Myocardial Ischemia

Oxidative Medicine and Cellular Longevity, 2022
Objective. This study is aimed at identifying the potential diagnostic markers for circulating endothelial cells (CECs) for acute myocardial ischemia (AMI) and exploring the regulatory mechanisms of the selected biomarker in mitochondrial oxidative damage and vascular inflammation in AMI pathology. Methods. Utilizing the Gene Expression Omnibus dataset
Tiechun Zhang, Dongyao Hou, Jianrong He, Xue Zeng, Ruixue Liu, Liangming Liu, Tao Li, Yingbin Xiao, Ruiyan Ma, He Huang, Chenyang Duan   +10 more
openaire   +2 more sources

Regulation of Autophagy in Chick Skeletal Muscle: Effect of mTOR Inhibition

The Journal of Poultry Science, 2020
Autophagy in the skeletal muscle increases under catabolic conditions resulting in muscle atrophy. This study investigated the effect of inhibition of mechanistic target of rapamycin (mTOR) on autophagy in chick skeletal muscle.
Kazuki Nakashima, Aiko Ishida
doaj   +1 more source

Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation

Cell Death and Disease, 2022
Channelling of glucose via glycogen, known as the glycogen shunt, may play an important role in the metabolism of brain tumours, especially in hypoxic conditions.
Christos E. Zois, Anne M. Hendriks, Syed Haider, Elisabete Pires, Esther Bridges, Dimitra Kalamida, Dimitrios Voukantsis, B. Christoffer Lagerholm, Rudolf S. N. Fehrmann, Wilfred F. A. den Dunnen, Andrei I. Tarasov, Otto Baba, John Morris, Francesca M. Buffa, James S. O. McCullagh, Mathilde Jalving, Adrian L. Harris   +16 more
doaj   +1 more source

An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

Cell Reports, 2023
Summary: The nucleolar scaffold protein NPM1 is a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants promoting its aberrant cytoplasmic localization, are the most frequent ...
Hannah Mende, Anshu Khatri, Carolin Lange, Sergio Alejandro Poveda-Cuevas, Georg Tascher, Adriana Covarrubias-Pinto, Frank Löhr, Sebastian E. Koschade, Ivan Dikic, Christian Münch, Anja Bremm, Lorenzo Brunetti, Christian H. Brandts, Hannah Uckelmann, Volker Dötsch, Vladimir V. Rogov, Ramachandra M. Bhaskara, Stefan Müller   +17 more
doaj   +1 more source

MicroRNA-195 regulates proliferation, migration, angiogenesis and autophagy of endothelial progenitor cells by targeting GABARAPL1 [PDF]

Bioscience Reports, 2016
Deep vein thrombosis (DVT) is a common type of venous thrombosis. Successful resolution of DVT-related thrombi is important in the treatment of DVT. Endothelial progenitor cells (EPCs) have emerged as a promising therapeutic choice for DVT-related thrombus resolution; however, the clinical application of EPCs faces many challenges. In the present study,
Mo, Jianwen, Zhang, Daifen, Yang, Renze
openaire   +2 more sources

Lafora disease offers a unique window into neuronal glycogen metabolism [PDF]

, 2018
Lafora disease (LD) is a fatal, autosomal recessive, glycogen-storage disorder that manifests as severe epilepsy. LD results from mutations in the gene encoding either the glycogen phosphatase laforin or the E3 ubiquitin ligase malin. Individuals with LD
Gentry, Matthew S., Guinovart, Joan J., Minassian, Berge A., Roach, Peter J., Serratosa, Jose M.   +4 more
core   +2 more sources

The regulation of the autophagic network and its implications for human disease [PDF]

, 2013
Autophagy has attracted a lot of attention in recent years. More and more proteins and signaling pathways have been discovered that somehow feed into the autophagy regulatory pathways.
Carra, Serena, Kampinga, Harm H., Yang, Jing, Zhu, Wei Guo   +3 more
core   +2 more sources

Fifteen days of 3200m simulated hypoxia marginally regulates markers for protein synthesis and degradation in human skeletal muscle [PDF]

, 2016
Chronic hypoxia leads to muscle atrophy. The molecular mechanisms responsible for this phenomenon are not well defined in vivo. We sought to determine how chronic hypoxia regulates molecular markers of protein synthesis and degradation in human skeletal ...
Bertrand, L, Bishop, David, D'Hulst, G, Deldique, L, Ferri, Alessandra, Francaux, M, Horman, S, Naslain, D   +7 more
core   +2 more sources

β‐Aminoisobutyric Acid Alleviates Cisplatin‐Induced Muscle Atrophy by Regulating E3 Ubiquitin Ligases, Apoptosis, Amino Acid Metabolism, Autophagy, and Ferroptosis

Medicine Bulletin, EarlyView.
ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang, Wen‐Bi He, Huan Wang, Hao Wang, Wen‐Jun Fang, Meng‐Qian Li, Jiong‐Xing Huang, Fei‐Peng Chen, Hui‐Guo Wang, Lin Zhu, Xiao‐Guang Liu   +10 more
wiley   +1 more source