Results 61 to 70 of about 2,771 (143)

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, Volume 293, Issue 8, Page 2314-2340, April 2026.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

[Retracted] Oxidative‐Damaged Mitochondria Activate GABARAPL1‐Induced NLRP3 Inflammasomes in an Autophagic‐Exosome Manner after Acute Myocardial Ischemia

Oxidative Medicine and Cellular Longevity, 2022
Objective . This study is aimed at identifying the potential diagnostic markers for circulating endothelial cells (CECs) for acute myocardial ischemia (AMI) and exploring the regulatory mechanisms of the selected biomarker in mitochondrial oxidative damage and vascular inflammation in AMI pathology.
Tiechun Zhang, Dongyao Hou, Jianrong He, Xue Zeng, Ruixue Liu, Liangming Liu, Tao Li, Yingbin Xiao, Ruiyan Ma, He Huang, Chenyang Duan   +10 more
openaire   +2 more sources

Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens

Cells, 2022
As a predominant hormone in the reproductive axis, follicle-stimulating hormone (FSH) is known as the primary surviving factor for follicular growth. In this study, the alleviating effect of FSH on aging chicken granulosa cells (GCs) was investigated ...
Juan Dong, Changquan Guo, Zhaoyu Yang, Yangyang Wu, Caiqiao Zhang   +4 more
doaj   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, Volume 16, Issue 3, Page 542-560, March 2026.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

GABARAPL1 is essential in extracellular vesicle cargo loading and metastasis development

Radiotherapy and Oncology
Hypoxia is a common feature of tumours, associated with poor prognosis due to increased resistance to radio- and chemotherapy and enhanced metastasis development. Previously we demonstrated that GABARAPL1 is required for the secretion of extracellular vesicles (EV) with pro-angiogenic properties during hypoxia.
Joel E.J. Beaumont, Jinzhe Ju, Lydie M.O. Barbeau, Imke Demers, Kim G. Savelkouls, Kasper Derks, Freek G. Bouwman, Marca H.M. Wauben, Marijke I. Zonneveld, Tom G.H. Keulers, Kasper M.A. Rouschop   +10 more
openaire   +5 more sources

Deficiency of GABARAP but Not Its Paralogs Causes Enhanced EGF-Induced EGFR Degradation

Cells, 2020
The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and GABARAPL2 constitute a subfamily of the autophagy-related 8 (Atg8) protein family.
Jochen Dobner, Indra M. Simons, Kerstin Rufinatscha, Sebastian Hänsch, Melanie Schwarten, Oliver H. Weiergräber, Iman Abdollahzadeh, Thomas Gensch, Johannes G. Bode, Silke Hoffmann, Dieter Willbold   +10 more
doaj   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

p38β MAPK mediates ULK1-dependent induction of autophagy in skeletal muscle of tumor-bearing mice

Cell Stress, 2018
Muscle wasting is the key manifestation of cancer-associated cachexia, a lethal metabolic disorder seen in over 50% of cancer patients. Autophagy is activated in cachectic muscle of cancer hosts along with the ubiquitin-proteasome pathway (UPP ...
Zhelong Liu, Ka Wai Thomas Sin, Hui Ding, HoangAnh Amy Doan, Song Gao, Hongyu Miao, Yahui Wei, Yiman Wang, Guohua Zhang, Yi-Ping Li   +9 more
doaj   +1 more source

Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a progressive, age‐related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction.
Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M. A. D. Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey‐Smith, Ralph Martins, Prashant Bharadwaj   +9 more
wiley   +1 more source

A novel multi-omics approach for identifying key genes in intervertebral disc degeneration

SLAS Technology
Many different cell types and complex molecular pathways are involved in intervertebral disc degeneration (IDD). We used a multi-omics approach combining single-cell RNA sequencing (scRNA-seq), differential gene expression analysis, and Mendelian ...
Xuan Zhao, Qijun Wang, Shuaikang Wang, Wei Wang, Xiaolong Chen, Shibao Lu   +5 more
doaj   +1 more source