Results 71 to 80 of about 4,298 (193)

Protective role of the Atg8 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease [PDF]

, 2021
SummaryDiabetic heart disease is highly prevalent and characterized by diastolic dysfunction. The mechanisms of diabetic heart disease are poorly understood and no targeted therapies are available. Here we show that the diabetic myocardium (type 1 and type 2) is characterized by marked glycogen elevation and ectopic cellular localization - a ...
Kimberley M. Mellor, Upasna Varma, Parisa Koutsifeli, Claire L. Curl, Johannes V. Janssens, Lorna J. Daniels, Gabriel B. Bernasochi, Antonia J.A. Raaijmakers, Victoria L. Benson, Eleia J. Chan, Marco Annandale, Xun Li, Yohanes Nursalim, Wendy T.K. Ip, David J. Taylor, Koen Raedschelders, Aleksandr Stotland, Aaron E. Robinson, Richard J. Mills, Regis R. Lamberts, Kim L. Powell, Terence J. O’Brien, Rajesh Katare, Chanchal Chandramouli, Rebecca H. Ritchie, Shiang Y. Lim, Robert G. Parton, Xinli Hu, James R. Bell, Enzo R. Porrello, James E. Hudson, Rui-Ping Xiao, Jennifer E. Van Eyk, Roberta A. Gottlieb, Lea M.D. Delbridge   +34 more
openaire   +1 more source

Glycogen and its metabolism: some new developments and old themes [PDF]

, 2012
Glycogen is a branched polymer of glucose that acts as a store of energy in times of nutritional sufficiency for utilization in times of need. Its metabolism has been the subject of extensive investigation and much is known about its regulation by ...
Depaoli-Roach, Anna A., Hurley, Thomas D., Roach, Peter J., Tagliabracci, Vincent S.   +3 more
core   +1 more source

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

The Carboxyl-Terminal Amino Acids Render Pro-Human LC3B Migration Similar to Lipidated LC3B in SDS-PAGE [PDF]

, 2013
LC3 is widely used marker for macroautophagy assays. After translation pro-LC3 is processed by Atg4 to expose C-terminal glycine residue for downstream conjugation reactions to accomplish the conversion of LC3-I to LC3-II. SDS-PAGE based Western blot (Wb)
Billiar, Timothy R., Chen, Zhixia, Gao, Wentao, Gasset, Maria, Stang, Michael T., Wang, Wei   +5 more
core   +6 more sources

Dysfunction of astrocytic glycophagy exacerbates reperfusion injury in ischemic stroke

Redox Biology
Glycophagy has evolved from an alternative glycogen degradation pathway into a multifaceted pivot to regulate cellular metabolic hemostasis in peripheral tissues.
Haiyun Guo, Yumeng Li, Shiquan Wang, Yongheng Yang, Tiantian Xu, Jianshuai Zhao, Jin Wang, Wenqiang Zuo, Pengju Wang, Guangchao Zhao, Huaning Wang, Wugang Hou, Hailong Dong, Yanhui Cai   +13 more
doaj   +1 more source

Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis

Journal of Experimental & Clinical Cancer Research, 2018
Background Autophagy plays a crucial role in sustaining the homeostasis in various malignant diseases. It has also been reported to promote tumor development in multiple cancers.
Xing Zhang, Zheng Li, Zhe Xuan, Penghui Xu, Weizhi Wang, Zheng Chen, Sen Wang, Guangli Sun, Jianghao Xu, Zekuan Xu   +9 more
doaj   +1 more source

AMPK in the central nervous system: physiological roles and pathological implications [PDF]

, 2016
5′ AMP-activated protein kinase (AMPK) is considered the master metabolic regulator in all eukaryotes, as it maintains cellular energy homeostasis in a variety of tissues, including the brain.
Fioramonti, Marco, Fracassi, Anna, Marangoni, Martina, Rosso, Pamela, Segatto, Marco, Siteni, Silvia, Taglietti, Valentina   +6 more
core   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Triggering a switch from basal- to luminal-like breast cancer subtype by the small-molecule diptoindonesin G via induction of GABARAPL1 [PDF]

Cell Death & Disease, 2020
AbstractBreast cancer is a heterogeneous disease that includes different molecular subtypes. The basal-like subtype has a poor prognosis and a high recurrence rate, whereas the luminal-like subtype confers a more favorable patient prognosis partially due to anti-hormone therapy responsiveness.
Minmin Fan, Jingwei Chen, Jian Gao, Wenwen Xue, Yixuan Wang, Wuhao Li, Lin Zhou, Xin Li, Chengfei Jiang, Yang Sun, Xuefeng Wu, Xudong Wu, Huiming Ge, Yan Shen, Qiang Xu   +14 more
openaire   +2 more sources

Reprogramming of lysosomal gene expression by interleukin-4 and Stat6. [PDF]

, 2013
BACKGROUND: Lysosomes play important roles in multiple aspects of physiology, but the problem of how the transcription of lysosomal genes is coordinated remains incompletely understood.
Bartlett, NW, Brignull, LM, Czimmerer, Z, Daniel, B, Johnston, SL, Meira, LB, Nagy, L, Nohturfft, A, Saidi, H, Villela, I   +9 more
core   +2 more sources