Results 71 to 80 of about 3,167 (176)
Cells, 2022 As a predominant hormone in the reproductive axis, follicle-stimulating hormone (FSH) is known as the primary surviving factor for follicular growth. In this study, the alleviating effect of FSH on aging chicken granulosa cells (GCs) was investigated ...
Juan Dong +4 more
doaj +1 more source
Medicine Bulletin, Volume 2, Issue 3, Page 256-267, June 2026.ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang +10 more
wiley +1 more source
GABARAPL1 Negatively Regulates Wnt/β-catenin Signaling by Mediating Dvl2 Degradation through the Autophagy Pathway [PDF]
Cellular Physiology and Biochemistry, 2011 Wnt signaling is critical for many biological processes and is tightly regulated. In this study, we found that GABARAPL1 (GABA(A) receptor-associated protein like 1, GABARAPL1) interacts with Dvl2 by both yeast two-hybrid screening and immunoprecipitation experiments.
Yanquan, Zhang +12 more
openaire +2 more sources
Oxidative Medicine and Cellular Longevity, 2022 Objective . This study is aimed at identifying the potential diagnostic markers for circulating endothelial cells (CECs) for acute myocardial ischemia (AMI) and exploring the regulatory mechanisms of the selected biomarker in mitochondrial oxidative damage and vascular inflammation in AMI pathology.
Tiechun Zhang +10 more
openaire +2 more sources
The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao +4 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 12, Page 3355-3376, June 2026.Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire +28 more
wiley +1 more source
GABARAPL1 expression in embryonic cortical primary cultures after Baf A1 treatment.
, 2013 Immunostaining using anti-GABARAPL1 (green) and anti-p62 (red) of embryonic cortical primary neurons incubated with or without Baf A1, a described inhibitor of the autophagic flux. The control cells show a diffuse and punctiform staining of GABARAPL1 and
Jianhua Zhang (6347) +7 more
core +1 more source
Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs [PDF]
Autophagy, 2019 Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1).
Åsa Birna Birgisdottir +11 more
openaire +4 more sources
Deficiency of GABARAP but Not Its Paralogs Causes Enhanced EGF-Induced EGFR Degradation
Cells, 2020 The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and GABARAPL2 constitute a subfamily of the autophagy-related 8 (Atg8) protein family.
Jochen Dobner +10 more
doaj +1 more source
Distribution of GABARAPL1 in the Mouse Brain.
, 2013 GABARAPL1 protein expression in different regions of the mouse CNS is displayed with a relative quantification of the intensity of staining observed. 0: absence of labeling, +: weak intensity, ++ moderate intensity, +++: strong intensity.
Jianhua Zhang (6347) +7 more
core +1 more source