Results 81 to 90 of about 2,771 (143)

ZNF197-AS1/miR-425/GABARAPL1 axis: a novel regulatory mechanism in uveal melanoma.

Am J Physiol Cell Physiol
This study identifies the ZNF197-AS1/miR-425/GABARAPL1 axis as a novel regulatory mechanism in uveal melanoma. ZNF197-AS1 upregulates GABARAPL1 by sponging miR-425, inhibiting UM cell proliferation, migration, and invasion. This discovery highlights a potential therapeutic target, providing new insights into UM progression and patient outcomes.
Zhang C, Wu S.
europepmc   +3 more sources

Glycophagy is involved in cardiac glycogen regulation in response to exercise

Current Research in Physiology
Cardiac glycogen-autophagy (‘glycophagy’) is disturbed in cardiometabolic pathologies. The physiological role of cardiac glycophagy is unclear. Exercise induces transient cardiac glycogen accumulation.
Samuel L. James, Parisa Koutsifeli, Randall F. D'Souza, Stewart WC. Masson, Jonathan ST. Woodhead, Troy L. Merry, Lea MD. Delbridge, Kimberley M. Mellor   +7 more
doaj   +1 more source

MicroRNA-143 enhances chemosensitivity of Quercetin through autophagy inhibition via target GABARAPL1 in gastric cancer cells

Biomedicine & Pharmacotherapy, 2015
MicroRNAs have emerged as fundamental regulators in gene expression through silencing gene expression at the post-transcriptional and translational levels. In this study, miR-143 expression and biological functions in AGS/MNK28 cell lines was investigated.
Fangjuan, Du, Yaxin, Feng, Jingzhong, Fang, Maowu, Yang   +3 more
openaire   +2 more sources

Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization

Scientific Reports, 2017
HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Studies have shown that the association of Nef with the inner leaflet of the plasma membrane and with endocytic and perinuclear vesicles is essential for most activities of Nef. Using
Alexandra Boeske, Melanie Schwarten, Peixiang Ma, Markus Tusche, Jessica Mötter, Christina Möller, Philipp Neudecker, Silke Hoffmann, Dieter Willbold   +8 more
doaj   +1 more source

Construction and evaluation of a prognostic model of autophagy-related genes in hepatocellular carcinoma

Biochemistry and Biophysics Reports
Background: Hepatocellular carcinoma (HCC) is a globally prevalent disease. Our article evaluates risk models based on autophagy- and HCC-related genes and their prognostic value by bioinformatics analytical methods to provide a scientific basis for ...
Yutao He, Bin Du, Weiran Liao, Wei Wang, Jifeng Su, Chen Guo, Kai Zhang, Zhitian Shi   +7 more
doaj   +1 more source

YIPF3 and YIPF4 regulate autophagic turnover of the Golgi apparatus

The EMBO Journal
The degradation of organelles by autophagy is essential for cellular homeostasis. The Golgi apparatus has recently been demonstrated to be degraded by autophagy, but little is known about how the Golgi is recognized by the forming autophagosome.
Shinri Kitta, Tatsuya Kaminishi, Momoko Higashi, Takayuki Shima, Kohei Nishino, Nobuhiro Nakamura, Hidetaka Kosako, Tamotsu Yoshimori, Akiko Kuma   +8 more
doaj   +1 more source

Sleeve Gastrectomy Alters Exosomal miR-497-5p Cargo to Ameliorate Metabolic Dysfunction–Associated Steatotic Liver by Targeting GABARAPL1

Diabetes, Metabolic Syndrome and Obesity
Zenghui Li,1,2 Chenxu Tian,1,2 Mengqin Wang,1,2 Zhehong Li,1,2 Liang Wang,1,2 Zheng Wang,1,2 Chengyuan Yu,1,2 Dezhong Wang,1,2 Dongbo Lian,1,2 Nengwei Zhang1,2 1Surgery Centre of Diabetes Mellitus, Beijing Shijitan Hospital, Capital Medical University ...
Li Z, Tian C, Wang M, Li Z, Wang L, Wang Z, Yu C, Wang D, Lian D, Zhang N   +9 more
doaj  

Decoding the brain’s ATG8 paralog code: LC3–GABARAP specialization at synapses and the astrocyte–neuron interface

Frontiers in Cell and Developmental Biology
Macroautophagy is essential for the long-term health of neurons and astrocytes in the central nervous system (CNS). The six mammalian ATG8 paralogs (LC3A/B/C and GABARAP/GABARAPL1/L2) exhibit an emerging “ATG8 code”—a division of labor among these ...
Haneul Choi, Seung-Min Lee, Jin-A. Lee
doaj   +1 more source

Correction: Insulin Inhibits Autophagy by Inhibiting the Binding of FoXO1 to the Promoter Region of GABARAPL1

Hormone and Metabolic Research, 2023
Jie Wen, Tao Hong, Lang Mei, Ruixiang Li, Junlin Zhou, Jiaoyang Li, Xin-Hua Xiao   +6 more
openaire   +2 more sources

Characterization of SARS‐CoV‐2 Entry Genes in Skeletal Muscle and Impacts of In Vitro Versus In Vivo Infection

Journal of Cachexia, Sarcopenia and Muscle
Background COVID‐19 has been associated with both respiratory (diaphragm) and non‐respiratory (limb) muscle atrophy. It is unclear if SARS‐CoV‐2 infection of skeletal muscle plays a role in these changes.
Salyan Bhattarai, Eva Kaufmann, Feng Liang, Yumin Zheng, Ekaterina Gusev, Qutayba Hamid, Jun Ding, Maziar Divangahi, Basil J. Petrof   +8 more
doaj   +1 more source