Results 91 to 100 of about 4,298 (193)

Analysis of Autophagy-Related Signatures Identified Two Distinct Subtypes for Evaluating the Tumor Immune Microenvironment and Predicting Prognosis in Ovarian Cancer

Frontiers in Oncology, 2021
Ovarian cancer (OC) is one of the most lethal gynecologic malignant tumors. The interaction between autophagy and the tumor immune microenvironment has clinical importance.
Xingyu Chen, Hua Lan, Dong He, Zhanwang Wang, Runshi Xu, Jing Yuan, Mengqing Xiao, Yao Zhang, Lian Gong, Songshu Xiao, Ke Cao   +10 more
doaj   +1 more source

Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a progressive, age‐related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction.
Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M. A. D. Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey‐Smith, Ralph Martins, Prashant Bharadwaj   +9 more
wiley   +1 more source

Deficiency of GABARAP but Not Its Paralogs Causes Enhanced EGF-Induced EGFR Degradation

Cells, 2020
The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and GABARAPL2 constitute a subfamily of the autophagy-related 8 (Atg8) protein family.
Jochen Dobner, Indra M. Simons, Kerstin Rufinatscha, Sebastian Hänsch, Melanie Schwarten, Oliver H. Weiergräber, Iman Abdollahzadeh, Thomas Gensch, Johannes G. Bode, Silke Hoffmann, Dieter Willbold   +10 more
doaj   +1 more source

Exacerbations and Management of Asthma in Viral Lower Respiratory Tract Infections: The Significance of Immunoglobulin E

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Viral‐respiratory infections are the most prevalent illness among humans. A viral infection affecting lower respiratory tract infections (LRTI) is a critical health concern worldwide. The COVID‐19 pandemic has significantly impacted respiratory health, particularly in individuals with asthma.
Mandana Akhavan, Parastoo Yousefi, Alireza Tabibzadeh   +2 more
wiley   +1 more source

Peptide OH‐CATH30 Mitigates Cachexia‐Induced Muscle Atrophy via Modulation of TLR4‐Associated Inflammation

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Cachexia, characterized by severe weight loss and muscle atrophy, frequently occurs in chronic conditions such as sepsis, cancer and chemotherapy, with limited effective treatments. Despite similar clinical manifestations, the underlying mechanisms across different disease contexts remain unclear.
Qiquan Wang, Jian Li, Mengqi Yang, Caifen Guo, Ming Zhang, Chunping Huang, Xiang Wang, Dongqin Zhang, Lin Zeng, Hao Ke, Yunling Wen, Shengan Li, Wenhui Lee, Limin Zhao, Xinqiang Lan, Yang Xiang   +15 more
wiley   +1 more source

Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs [PDF]

Autophagy, 2019
Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase complex I (PtdIns3K-C1).
Åsa Birna Birgisdottir, Stephane Mouilleron, Zambarlal Bhujabal, Martina Wirth, Eva Sjøttem, Gry Evjen, Wenxin Zhang, Rebecca Lee, Nicola O’Reilly, Sharon A. Tooze, Trond Lamark, Terje Johansen   +11 more
openaire   +4 more sources

Exploring exosome-related genes as candidate biomarkers in primary immune thrombocytopenia through transcriptomics and preliminary experimental validation

Scientific Reports
Primary Immune Thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia and bleeding tendency. Exosomes mediate abnormal crosstalk between immune cells and megakaryocytes in ITP, suggesting that exosome-related genes may serve as
Fangfang Lou, Zhiyue Chen, Zihao Yuan, Jie Peng, Jiangyu Sun, Ping Huang, Zesong Yang   +6 more
doaj   +1 more source

p38β MAPK mediates ULK1-dependent induction of autophagy in skeletal muscle of tumor-bearing mice

Cell Stress, 2018
Muscle wasting is the key manifestation of cancer-associated cachexia, a lethal metabolic disorder seen in over 50% of cancer patients. Autophagy is activated in cachectic muscle of cancer hosts along with the ubiquitin-proteasome pathway (UPP ...
Zhelong Liu, Ka Wai Thomas Sin, Hui Ding, HoangAnh Amy Doan, Song Gao, Hongyu Miao, Yahui Wei, Yiman Wang, Guohua Zhang, Yi-Ping Li   +9 more
doaj   +1 more source

p62/SQSTM1 Condensation Modulates Mitochondrial Clustering to Participate in Mitochondrial Quality Control

Aging Cell, Volume 25, Issue 2, February 2026.
In normal PINK1/Parkin‐mediated mitophagy, unlike OPTN (the mitophagy receptor that mediates ATG8‐labeled autophagosome recruitment onto ubiquitinated mitochondria), p62 mediates the clustering of ubiquitinated mitochondria to form the “grape‐like” aggregates with ubiquitin.
Shan Sun, Jiaqi Xin, Yingping Zhang, Bojun Yang, Dan Su, Rui Ni, Qilian Ma, Ningning Li, Guoqiang Ma, Qiang Peng, Siqian Chen, Jochen H. M. Prehn, Kin Yip Tam, Hongfeng Wang, Zheng Ying   +14 more
wiley   +1 more source

GABARAPL1 is differentially expressed in the brains of patients with psychotic disorders.

, 2020
We used public and published microarray data (1, 2) to identify the most significant gene expression changes in the brains of patients with psychotic disorders. We identified the 𝛄-aminobutyric acid receptor-associated protein-like 1 GABARAPL13 as differentially expressed in the dorsolateral prefrontal cortex of patients with schizophrenia as well as ...
openaire   +2 more sources