Results 111 to 120 of about 4,298 (193)

Circadian Rhythm: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 11, November 2025.
This review offers a comprehensive overview of the mechanisms by which circadian rhythms modulate tissue homeostasis, alongside the associations between circadian disturbances and circadian rhythm‐related diseases. Furthermore, we offer insights into circadian rhythm‐regulating therapies, which may contribute to the development of novel strategies for ...
Kangkang Zha, Bobin Mi, Yuan Xiong, Shuyan Wu, Li Lu, Shengming Zhang, Xuan Lu, Hei Chung Mak, Jianping Huang, Adriana C. Panayi, Samuel Knoedler, Lili Chen, Guohui Liu, Sien Lin   +13 more
wiley   +1 more source

The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation. [PDF]

, 2017
Natural killer (NK) cells are a diverse population of lymphocytes with a range of biological roles including essential immune functions. NK cell diversity is in part created by the differential expression of cell surface receptors which modulate ...
Bickhart, Derek M, Gibson, Mark S, Hammond, John A, Heimeier, Dorothea, Koren, Sergey, Medrano, Juan F, Phillippy, Adam M, Schwartz, John C, Smith, Timothy PL   +8 more
core   +2 more sources

Advantages and Possibility of Transcription Factors FOXOs in HCC

Cell Biochemistry and Function, Volume 43, Issue 10, October 2025.
ABSTRACT The forkhead frame O protein (forkhead box class O proteins, FOXOs) is a highly conserved family of transcription factors, consisting of four members: FOXO 1, FOXO 3, FOXO 4, and FOXO 6. The FOXOs protein family is a ubiquitously expressed transcription factor involved in the regulation of cell cycle, cell proliferation, apoptosis, autophagy ...
Gu Xiufeng, Hu Zhiping, Wang Jingzhi
wiley   +1 more source

GABARAPL1 acts as a potential marker and promotes tumor proliferation and metastasis in triple negative breast cancer

Oncotarget, 2017
GABAA-receptor-associated protein like-1 (GABARAPL1) is involved in a variety of cancers. The purpose of this study was to investigate the expression, prognostic roles and functions of GABARAPL1 in triple negative breast cancer (TNBC). Quantitative real-time PCR (qRT-PCR) showed that GABARAPL1 was up regulated in both TNBC cell lines and clinical TNBC ...
Ran, Li, Hong, Tao, Xiao, Xinhua, Xie, Liming, Zhou, Junlin, Wen, Gebo   +5 more
openaire   +2 more sources

Regulation of Autophagy in Chick Myotubes: Effects of Insulin, Insulin-Like Growth Factor-I, and Amino Acids

The Journal of Poultry Science, 2018
Autophagy, an intracellular bulk protein degradation system in skeletal muscle, is increased under catabolic conditions resulting in muscle atrophy. This study aimed to investigate the effects of insulin, insulin-like growth factor (IGF)-I, and amino ...
Kazuki Nakashima, Aiko Ishida
doaj   +1 more source

Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacological modulation [PDF]

, 2015
Acute myeloid leukemia (AML) is characterized by the accumulation of immature blood cell precursors in the bone marrow. Pharmacologically overcoming the differentiation block in this condition is an attractive therapeutic avenue, which has achieved ...
Ablain, Adrian Britschgi, Brigger, Britschgi, Burnett, Cassinat, Chakrama, Chen, Choi, Conway, Crowley, Dos Santos, Elzinga, Feng, Finch, Focosi, Guan, Gupta, He, Humbert, Isakson, Jeanne, Jung, Kimura, Lihuan, Liu, Lo-Coco, Lorraine J. Gudas, Mario P. Tschan, Mary R. Cahill, Michelle J. Nyhan, Miller, Mizushima, Mizushima, Mortensen, Nasr, Nencioni, Nigel P. Mongan, Nina Orfali, Orfali, Pasquali, Quiroz, Renna, Sarkar, Shao, Sharon L. McKenna, Si, Sokoloski, Strohecker, Tang, Townsend, Tracey R. O'Donovan, Trocoli, Trocoli, Wang, Weidberg, White, Wu, Yousefi, Zhang, Zhang   +60 more
core   +1 more source

Establishing the role of rare coding variants in known Parkinson's disease risk loci [PDF]

, 2017
Many common genetic factors have been identified to contribute to Parkinson's disease (PD) susceptibility, improving our understanding of the related underlying biological mechanisms.
Brice, A, Gasser, T, Gibbs, JR, Hardy, J, Heutink, P, Int Parkinsons Genomics, C, Jansen, IE, Kraaij, Robert, Lubbe, S, Morris, HR, Nalls, MA, Price, T R, Sharma, M, Singleton, AB, Uitterlinden, André, van Rooij, J, Williams, NM, Wood, NW   +17 more
core   +3 more sources

The mammalian ULK1 complex and autophagy initiation [PDF]

, 2017
Autophagy is a vital lysosomal degradation pathway that serves as a quality control mechanism. It rids the cell of damaged, toxic or excess cellular components, which if left to persist could be detrimental to the cell.
Bach, Bento, Chan, Chan, Chauhan, Chen, Cheong, Chude, Di Bartolomeo, Dunlop, Egan, Egan, Farre, Fullgrabe, Gammoh, Gan, Gan, Ganley, Henckaerts, Hieke, Hosokawa, Hosokawa, Ian G. Ganley, Itakura, James T. Murray, Jiang, Jon D. Lane, Joo, Jung, Kaizuka, Kaizuka, Karanasios, Karanasios, Kim, Konno, Koyama-Honda, Kundu, Lamark, Lazarou, Lazarus, Lee, Li, Li, Li, Li, Lim, Lin, Lin, Liu, Liu, Maria Zachari, McWilliams, Mercer, Nazio, Nazio, Ochaba, Orsi, Pengo, Petherick, Pickrell, Pike, Puente, Puri, Qi, Rabanal-Ruiz, Rui, Russell, Sarraf, Schneider, Sellier, Su, Sun, Suzuki, Tian, Torii, Ugolino, Viktor I. Korolchuk, Wang, Webster, Wold, Wong, Wu, Xu, Yang, Young, Yun, Zhou, Zou   +87 more
core   +2 more sources

Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration [PDF]

, 2017
Hematopoietic stem and progenitor cells (HSPCs) are predominantly quiescent in adults, but proliferate in response to bone marrow (BM) injury. Here, we show that deletion of Ca2+/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) promotes HSPC ...
Arvai, Stephanie, Chao, Nelson, Doan, Phuong L, Harris, Jeffrey R, Huang, Wei, Lento, William, Liu, Yaping, Marcon, Fernando, Nakaya, Helder I, Racioppi, Luigi   +9 more
core   +1 more source

MicroRNA-143 enhances chemosensitivity of Quercetin through autophagy inhibition via target GABARAPL1 in gastric cancer cells

Biomedicine & Pharmacotherapy, 2015
MicroRNAs have emerged as fundamental regulators in gene expression through silencing gene expression at the post-transcriptional and translational levels. In this study, miR-143 expression and biological functions in AGS/MNK28 cell lines was investigated.
Fangjuan, Du, Yaxin, Feng, Jingzhong, Fang, Maowu, Yang   +3 more
openaire   +2 more sources