Results 121 to 130 of about 4,298 (193)

Glycophagy is involved in cardiac glycogen regulation in response to exercise

Current Research in Physiology
Cardiac glycogen-autophagy (‘glycophagy’) is disturbed in cardiometabolic pathologies. The physiological role of cardiac glycophagy is unclear. Exercise induces transient cardiac glycogen accumulation.
Samuel L. James, Parisa Koutsifeli, Randall F. D'Souza, Stewart WC. Masson, Jonathan ST. Woodhead, Troy L. Merry, Lea MD. Delbridge, Kimberley M. Mellor   +7 more
doaj   +1 more source

Rationalising the role of Keratin 9 as a biomarker for Alzheimer’s disease [PDF]

, 2016
Keratin 9 was recently identified as an important component of a biomarker panel which demonstrated a high diagnostic accuracy (87%) for Alzheimer’s disease (AD).
A Byron, A Panchaud, A Reddy, A Reis, AG Madian, AK Deo, B Catimel, B Vafadar-Isfahani, B von Eyss, BM Riederer, BS Fu, C Ballard, C Behrends, C Bohm, C Johnson, C Mueller, C Parr, CJ Tu, CW Guo, D Bohm, D Croft, D Croft, D Ghosh, DJ Araujo, DJ Fu, EA Otto, EJ Bennett, F Caraci, F Lopitz-Otsoa, G Singh, G van Niel, GN Yin, GV De Ferrari, GV De Ferrari, I Alafuzoff, J Colas, J Jin, J Kim, J Nicholson, JC Jones, JC Mellor, JD Humphries, JG Veening, JL Richens, JL Richens, JR Denery, JS Bett, KS Carmon, L Langbein, L Liu, L Sang, L Sennels, M Bassani-Sternberg, M Brehme, M Cortes-Canteli, M Homberg, M Noguchi, M Thambisetty, M Zhou, N Sato, P Buchhave, PC Havugimana, PG Hawkins, R Killick, R Moll, RL Prentice, S de Mateo, S Fatima, S Jiang, S Liebner, S Pan, SJ Roy, SK Jeong, T Bouwmeester, T Farrah, T Glatter, T Manabe, U Stelzl, WJ Qian, WJ Qian, X Li, X Liu, Y Fang, Y Shimomura, Y Yamaguchi, YS Kim, Z Hu, ZF Du   +87 more
core   +2 more sources

GABARAPL1 tumor suppressive function is independent of its conjugation to autophagosomes in MCF-7 breast cancer cells

Oncotarget, 2017
The GABARAPL1 protein belongs to the ATG8 family whose members are involved in autophagy. Our laboratory previously demonstrated that GABARAPL1 associates with autophagic vesicles, regulates autophagic flux and acts as a tumor suppressor protein in breast cancer.
Poillet-Perez, Laura, Jacquet, Marine, Hervouet, Eric, Gauthier, Thierry, Fraichard, Annick, Borg, Christophe, Pallandre, Jean-René, Gonzalez, Bruno, J., Ramdani, Yasmina, Boyer-Guittaut, Michael, Delage-Mourroux, Régis, Despouy, Gilles   +11 more
openaire   +4 more sources

Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy [PDF]

, 2016
published_or_final_versio
Ge, R, Irwin, MG, KANDULA, V, Kosuru, R, Li, H, Lian, Q, Xia, Z, YAN, D, Zhu, Q   +8 more
core   +1 more source

Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila [PDF]

, 2012
Autophagy delivers cytoplasmic material for lysosomal degradation in eukaryotic cells. Starvation induces high levels of autophagy to promote survival in the lack of nutrients. We compared genome-wide transcriptional profiles of fed and starved control,
Juhász, Gábor, Ménesi, Dalma, Nagy, Péter, Pircs, Karolina, Puskás, László G., Varga, Ágnes, Zvara, Ágnes, Érdi, Balázs   +7 more
core   +1 more source

Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization

Scientific Reports, 2017
HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Studies have shown that the association of Nef with the inner leaflet of the plasma membrane and with endocytic and perinuclear vesicles is essential for most activities of Nef. Using
Alexandra Boeske, Melanie Schwarten, Peixiang Ma, Markus Tusche, Jessica Mötter, Christina Möller, Philipp Neudecker, Silke Hoffmann, Dieter Willbold   +8 more
doaj   +1 more source

The role of Nrf2 signaling in counteracting neurodegenerative diseases [PDF]

, 2018
The transcription factor Nrf2 (nuclear factor-erythroid 2 p45-related factor 2) functions at the interface of cellular redox and intermediary metabolism.
Abeti, Acosta, Alarcon-Aguilar, Bartolome, Baxter, Bell, Bellaver, Bott, Calap-Quintana, Chen, Chowdhry, Clark, Corenblum, Csiszar, Csiszar, Cullinan, D'Oria, Dayalan Naidu, Dinkova-Kostova, Dinkova-Kostova, Dinkova-Kostova, Dinkova-Kostova, Dinkova-Kostova, East, Esteras, FangFang, Flowers, Fragoulis, Georgakopoulos, Giordano, Goode, Goode, Gotzl, Greco, Greco, Hardie, Hayes, Hensley, Hoenen, Holmstrom, Jang, Jarrott, Jazwa, Jimenez-Sanchez, Jin, Johnson, Joshi, Kandimalla, Kerr, Knatko, Kobayashi, Kobayashi, Komatsu, Kovacs, Kubben, Kumar, Kumar, Kwak, Kwon, Lastres-Becker, Lee, Liddell, Linker, Lipton, Liu, Lo, Ludtmann, Luis, Meng, Mitsuishi, Moinova, Morrison, Mota, Moujalled, Navarro, Neymotin, Olagnier, Pajares, Paupe, Piantadosi, Polymeropoulos, Prasad, Prasad, Quinti, Quinti, Rada, Rainero, Rojo, Rojo, Sabouny, Sahdeo, Serini, Shan, Sheng, Skibinski, Stack, Thimmulappa, Tian, Townsend, Tufi, Valente, Vargas, Vargas, Vargas, Wang, Wild, Williamson, Wu, Wu, Yamazaki, Yang, Zhang, Zhang   +112 more
core   +2 more sources

Morbus Crohn—a disease of failing macroautophagy in the immune system? [PDF]

, 2017
Mutations in genes involved in macroautophagy have been found to be associated with Morbus Crohn, also called Crohn's disease (CD), an inflammatory bowel disease.
Meixlsperger, Sonja, Münz, Christian
core  

Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy [PDF]

, 2013
Several myopathies are associated with defects in autophagic and lysosomal degradation of glycogen, but it remains unclear how glycogen is targeted to the lysosome and what significance this process has for muscle cells.
Nieuwenhuis, Joppe, Perrimon, Norbert, Zirin, Jonathan   +2 more
core   +3 more sources

Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells [PDF]

, 2008
BACKGROUND: Neuronal tissue has limited potential to self-renew or repair after neurological diseases. Cellular therapies using stem cells are promising approaches for the treatment of neurological diseases.
Tatiana Tondreau, Marielle Dejeneffe, Nathalie Meuleman, Basile Stamatopoulos, Alain Delforge, Philippe Martiat, Dominique Bron, Laurence Lagneaux   +7 more
core   +2 more sources