Results 51 to 60 of about 3,167 (176)

GABARAPL1 expression in the telencephalon.

, 2013
Immunohistochemical analysis of WT mouse brain tissue with an anti-GABARAPL1 antibody. Images represent typical GABARAPL1 protein expression patterns in neurons found in the cortex-CTX (b), caudate putament-CP (c) and nucleus of the diagonal band-NDB (d).
Jianhua Zhang (6347), Karine Bon (587305), Michèle Jouvenot (514243), Régis Delage-Mourroux (514244), Michaël Boyer-Guittaut (25527), Annick Fraichard (587306), Jaclyn Nicole Le Grand (587304), Pierre-Yves Risold (337103)   +7 more
core   +1 more source

Protective role of the Atg8 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease [PDF]

, 2021
Summary Diabetic heart disease is highly prevalent and characterized by diastolic dysfunction. The mechanisms of diabetic heart disease are poorly understood and no targeted therapies are available. Here we show that the diabetic myocardium (type 1 and type 2) is characterized by marked glycogen elevation and ectopic ...
Kimberley M. Mellor, Upasna Varma, Parisa Koutsifeli, Claire L. Curl, Johannes V. Janssens, Lorna J. Daniels, Gabriel B. Bernasochi, Antonia J.A. Raaijmakers, Victoria L. Benson, Eleia J. Chan, Marco Annandale, Xun Li, Yohanes Nursalim, Wendy T.K. Ip, David J. Taylor, Koen Raedschelders, Aleksandr Stotland, Aaron E. Robinson, Richard J. Mills, Regis R. Lamberts, Kim L. Powell, Terence J. O’Brien, Rajesh Katare, Chanchal Chandramouli, Rebecca H. Ritchie, Shiang Y. Lim, Robert G. Parton, Xinli Hu, James R. Bell, Enzo R. Porrello, James E. Hudson, Rui-Ping Xiao, Jennifer E. Van Eyk, Roberta A. Gottlieb, Lea M.D. Delbridge   +34 more
openaire   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

GABARAPL1 expression during embryonic development (E11 to E17).

, 2013
Western blotting analysis of WT mouse head tissue protein extracts using anti-GABARAPL1 and anti-Actin antibodies (a). Quantification of GABARAPL1 protein expression levels in the developing embryonic mouse brain (b).
Jianhua Zhang (6347), Karine Bon (587305), Michèle Jouvenot (514243), Régis Delage-Mourroux (514244), Michaël Boyer-Guittaut (25527), Annick Fraichard (587306), Jaclyn Nicole Le Grand (587304), Pierre-Yves Risold (337103)   +7 more
core   +1 more source

Distinct Gene Expression Profiles of Ara h 2‐Specific B Cells in Desensitization and Tolerance During Peanut Oral Immunotherapy

Allergy, EarlyView.
Gene expression of Ara h 2‐specific B cells over the course of the peanut OIT. Isotype of allergen‐specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen‐specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation.
Stephan R. Schneider, Juan‐Felipe López, Huseyn Babayev, Willem van de Veen, Minglin Yang, Cezmi A. Akdis, Kari Nadeau, Carolyn H. Baloh, Stacie M. Jones, Lisa M. Wheatley, Mübeccel Akdis, IMPACT, Amy M. Scurlock, D. Pesek, Joy Laurienzo‐Panza, Marshall Plaut, A. Wesley Burks, Edwin H. Kim, Mike Kulis, Anna Nowak‐Wegrzyn, Hugh A. Sampson, Julie Wang, Robert A. Wood, Sharon Chinthrajah, Robert Sayantani B. Sindher, Jacqueline Johnson, Katharine Spain, Denise C. Babineau, Hyunsook Chin, Rachel Yan, Don Whitehouse, Michelle L. Sever, Srinath Sanda, David Larson, Tielin Qin, Gina Marchesini, Kavitha Gilroy, Sylvia Posso, Sabrina Skiba, Thien‐Son Nguyen, Adam Wojno, Tuan Nguyen, Vivian Gersuk, Quynh‐Anh Nguyen, Jessica Garber, Kimberly O'Brien, Brandon Larson, C. Cousens‐Jacobs, Alex Hu   +48 more
wiley   +1 more source

Dysfunction of astrocytic glycophagy exacerbates reperfusion injury in ischemic stroke

Redox Biology
Glycophagy has evolved from an alternative glycogen degradation pathway into a multifaceted pivot to regulate cellular metabolic hemostasis in peripheral tissues.
Haiyun Guo, Yumeng Li, Shiquan Wang, Yongheng Yang, Tiantian Xu, Jianshuai Zhao, Jin Wang, Wenqiang Zuo, Pengju Wang, Guangchao Zhao, Huaning Wang, Wugang Hou, Hailong Dong, Yanhui Cai   +13 more
doaj   +1 more source

Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis

Journal of Experimental & Clinical Cancer Research, 2018
Background Autophagy plays a crucial role in sustaining the homeostasis in various malignant diseases. It has also been reported to promote tumor development in multiple cancers.
Xing Zhang, Zheng Li, Zhe Xuan, Penghui Xu, Weizhi Wang, Zheng Chen, Sen Wang, Guangli Sun, Jianghao Xu, Zekuan Xu   +9 more
doaj   +1 more source

Genetic and Pharmacologic Inhibition of Myostatin Restores Muscle Mass in a Dynamin 2‐Related Centronuclear Myopathy Mouse Model

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Autosomal dominant centronuclear myopathy (ADCNM), most commonly caused by mutations in the dynamin 2 (DNM2) gene, is a rare congenital myopathy characterized by progressive muscle weakness and atrophy. Myostatin, a key negative regulator of skeletal muscle mass, has shown therapeutic potential in several models of neuromuscular ...
Durieux Anne‐Cécile, Arnould David, Velarde Mathias, Allibert Valentine, Paret Chloé, Debelley Quentin, Kizilkilic Esra, Chambon Sidney, Girard Emmanuelle, Collin Louise, Gensel Alexandre, Castells Josiane, Pasternack Aja, Bowen Maximilien, Morel Baptiste, Hourdé Christophe, Laurent Schaeffer, Ritvos Olli, Bitoun Marc, Mounier Rémi, Freyssenet Damien   +20 more
wiley   +1 more source

MicroRNA-195 regulates proliferation, migration, angiogenesis and autophagy of endothelial progenitor cells by targeting GABARAPL1 [PDF]

Bioscience Reports, 2016
Deep vein thrombosis (DVT) is a common type of venous thrombosis. Successful resolution of DVT-related thrombi is important in the treatment of DVT. Endothelial progenitor cells (EPCs) have emerged as a promising therapeutic choice for DVT-related thrombus resolution; however, the clinical application of EPCs faces many challenges. In the present study,
Mo, Jianwen, Zhang, Daifen, Yang, Renze
openaire   +2 more sources

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources