Results 51 to 60 of about 4,298 (193)

The selectivity and specificity of autophagy in drosophila [PDF]

, 2012
Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a ...
Chou, Clark, Contamine, Deng, Dezelee, Finley, Fouillet, Goto, Kadandale, McPhee, Midorikawa, Nezis, Nisoli, Novak, Orvedahl, Pankiv, Park, Rello-Varona, Schweers, Shoji, Simonsen, Tian, Webb, Wild, Wyers, Yu, Yu, Ziviani   +27 more
core   +2 more sources

Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2 [PDF]

BioMed Research International, 2020
Background. Sevoflurane is commonly used as a general anesthetic in neonates to aged patients. Preconditioning or postconditioning with sevoflurane protects neurons from excitotoxic injury. Conversely, sevoflurane exposure induces neurotoxicity during early or late life.
Guolin Lu, Dongdong Rao, Min Zhou, null Liangpu Xu, Longxin Zhang, Sujing Zhang, Yuping Wang   +6 more
openaire   +2 more sources

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources

Identification of Hub Genes and Typing of Tuberculosis Infections Based on Autophagy-Related Genes

Polish Journal of Microbiology, 2023
Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the leading causes of morbidity and death in humans worldwide. Some autophagy genes associated with TB and some miRNAs regulating TB have been found, but the identification of autophagy ...
Sheng Yunfeng, Hua Haibo, Yong Yan, Zhou Lihong   +3 more
doaj   +1 more source

Gamma‐Aminobutyric Acid System Genes—No Evidence for a Role in Alcohol Use and Abuse in a Community‐Based Sample [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106921/1/acer12352 ...
Addolorato, Agrawal, Begleiter, Bettler, Boyle, Covault, Cui, Derringer, Dick, Dick, Drgon, Edenberg, Enoch, Enoch, Enoch, Fehr, Gao, Grant, Grobin, Heath, Hodgkinson, Hunt, Iacono, Iacono, Johnson, Kanehisa, Koob, Kumar, Kuo, Lappalainen, Li, Lind, Lind, Liu, Lobo, Matthews, McGue, McGue, Meguro, Miller, Onori, Price, Purcell, Rice, Robins, Saccone, Sander, Slutske, Uusi-Oukari, Visscher, Winterer, Yang   +51 more
core   +1 more source

GABARAPL1 suppresses metastasis by counteracting PI3K/Akt pathway in prostate cancer

Oncotarget, 2016
Metastasis remains the primary cause of prostate cancer (CaP)-related death. Using a genome wide shRNA screen, we identified GABARAPL1 as a potential CaP metastasis suppressor. GABARAPL1 mRNA levels inversely correlate with the invasive potential of a panel of human CaP cell lines.
Su, Wei, Li, Shibao, Chen, Xiaofan, Yin, Lingyu, Ma, Ping, Ma, Yingyu, Su, Bing   +6 more
openaire   +4 more sources

GABARAPL1 Negatively Regulates Wnt/β-catenin Signaling by Mediating Dvl2 Degradation through the Autophagy Pathway [PDF]

Cellular Physiology and Biochemistry, 2011
Wnt signaling is critical for many biological processes and is tightly regulated. In this study, we found that GABARAPL1 (GABA(A) receptor-associated protein like 1, GABARAPL1) interacts with Dvl2 by both yeast two-hybrid screening and immunoprecipitation experiments.
Yanquan, Zhang, Fang, Wang, Liang, Han, Yinyuan, Wu, Shan, Li, Xi, Yang, Yinyin, Wang, Fangli, Ren, Yonggong, Zhai, Dianjun, Wang, Baoqing, Jia, Yongjing, Xia, Zhijie, Chang   +12 more
openaire   +2 more sources

Histone lysine demethylase 3B regulates autophagy via transcriptional regulation of GABARAPL1 in acute myeloid leukemia cells

International Journal of Oncology, 2023
Macroautophagy (hereafter referred to as autophagy) is a highly conserved self‑digestion process that is critical for maintaining homeostasis in response to various stresses. The autophagy‑related protein family, including the GABA type A receptor‑associated protein (GABARAP) and microtubule‑associated protein 1 light chain 3 subfamilies, is crucial ...
Song, Ying, Zhang, Jiaqi, Wang, Haihua, Wang, Haiying, Liu, Yong, Hu, Zhenbo   +5 more
openaire   +2 more sources

Dysfunctional energy and future perspective of low dose H2O2 as protective agent in neurodegenerative disease

Heliyon, 2023
The number of people with neurodegenerative disease continues to increase every year. A new perspective is needed to overcome this disease. In this review, researchers collected information about dysfunctional energy in neurodegenerative diseases driven ...
Sri Widyarti, Syahputra Wibowo, Akhmad Sabarudin, Intan Abhirama, Sutiman Bambang Sumitro   +4 more
doaj   +1 more source

Gene expression profile and signaling pathways in MCF-7 breast cancer cells mediated by acyl-CoA synthetase 4 overexpression [PDF]

, 2015
Aim: Breast cancer comprises a heterogeneous group of diseases that vary in morphology, biology, behavior and response to therapy. Previous studies have identified an acyl-CoA synthetase 4 (ACSL4) gene-expression pattern correlated with very aggressive ...
Castillo, Ana Fernanda, Lopez, Paula Veronica, Maloberti, Paula Mariana, Orlando, Ulises Daniel, Podesta, Ernesto Jorge, Solano, Angela Rosario   +5 more
core   +1 more source