Results 31 to 40 of about 3,167 (176)

Bi-allelic ATG4D variants are associated with a neurodevelopmental disorder characterized by speech and motor impairment

npj Genomic Medicine, 2023
Autophagy regulates the degradation of damaged organelles and protein aggregates, and is critical for neuronal development, homeostasis, and maintenance, yet few neurodevelopmental disorders have been associated with pathogenic variants in genes encoding
Marie Morimoto, Vikas Bhambhani, Nour Gazzaz, Mariska Davids, Paalini Sathiyaseelan, Ellen F. Macnamara, Jennifer Lange, Anna Lehman, Patricia M. Zerfas, Jennifer L. Murphy, Maria T. Acosta, Camille Wang, Emily Alderman, Undiagnosed Diseases Network, Sara Reichert, Audrey Thurm, David R. Adams, Wendy J. Introne, Sharon M. Gorski, Cornelius F. Boerkoel, William A. Gahl, Cynthia J. Tifft, May Christine V. Malicdan   +22 more
doaj   +1 more source

Cytoprotective autophagy induction by withaferin A in prostate cancer cells involves GABARAPL1 [PDF]

Molecular Carcinogenesis, 2020
AbstractWithaferin A (WA) is a naturally occurring steroidal lactone with proven cancer chemopreventive activity in preclinical models of different cancers including prostate adenocarcinoma. Previously we compared the RNA‐seq data from control and WA‐treated 22Rv1 human prostate cancer cells to identify mechanistic targets of this phytochemical.
Eun‐Ryeong Hahm, Shivendra V. Singh
openaire   +2 more sources

Herpesvirus lytic infection-induced mitophagy via viral interferon regulatory factor 1

Autophagy Reports, 2023
Viral control of mitochondria via mitophagy has a dampening effect on mitochondrion-mediated innate immune responses. We previously found that human herpesvirus 8 (HHV-8) could activate mitophagy via its lytic gene product vIRF-1 (viral interferon ...
Mai Tram Vo, Young Bong Choi
doaj   +1 more source

Insulin Inhibits Autophagy by Inhibiting the Binding of FoXO1 to the Promoter Region of GABARAPL1

Hormone and Metabolic Research, 2023
AbstractHyperinsulinemia and insulin resistance in T2D have a potent suppressive effect on hepatic autophagy, however, the underlying mechanisms remain unclear. To explore the effect of insulin on hepatic autophagy and its possible signaling pathways, HL-7702 cells were treated with insulin ...
Jie Wen, Tao Hong, Lang Mei, Ruixiang Li, Junlin Zhou, Jiaoyang Li, Xin-Hua Xiao   +6 more
openaire   +2 more sources

MiR-145 inhibits the differentiation and proliferation of bone marrow stromal mesenchymal stem cells by GABARAPL1 in steroid-induced femoral head necrosis

BMC Musculoskeletal Disorders, 2022
Steroid-induced osteonecrosis of femoral head (SANFH) involves impaired differentiation of bone marrow mesenchymal stem cells (BMSC), the mechanism of which is regulated by multiple microRNAs.
Pengfei Xu, Jun Chang, Guangwen Ma, Faxue Liao, Tangbing Xu, Yunfeng Wu, Zongsheng Yin   +6 more
doaj   +1 more source

Induction of the expression of GABARAPL1 by hydrogen peroxide in C6 glioma cells [PDF]

Integrative Molecular Medicine, 2015
Ischemia-reperfusion or traumatic brain injury induces the accumulation of reactive oxygen species (ROS) in brain. ROS causes oxidative stress to astrocytes as well as neurons and oxidative stress induces the damage to organelles, proteins or lipids.
Hiromi Nochi, Yoshimitsu Kiriyama, Kunihiko Kasai, Katsuhito Kino   +3 more
openaire   +1 more source

Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2 [PDF]

BioMed Research International, 2020
Background. Sevoflurane is commonly used as a general anesthetic in neonates to aged patients. Preconditioning or postconditioning with sevoflurane protects neurons from excitotoxic injury. Conversely, sevoflurane exposure induces neurotoxicity during early or late life.
Guolin Lu, Dongdong Rao, Min Zhou, null Liangpu Xu, Longxin Zhang, Sujing Zhang, Yuping Wang   +6 more
openaire   +2 more sources

Targeting GABARAPL1/HIF-2a in nasopharyngeal carcinoma

, 2023
Abstract The primary gene mutations associated with nasopharyngeal carcinoma (NPC) are located within phosphoinositide 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling pathways. These pathways have inhibitory effects on autophagy, and autophagy has become an important area of NPC research.
Xiaopeng Huang, Liya Zhou, Jiawei Chen, Shuai Zhang   +3 more
openaire   +1 more source

Identification of single residues of GABARAPL1 required for vIRF-1 binding.

, 2023
(A-C) GST pull-down assays were performed with purified vIRF-1-T7 and the following GST-fused LC3B or GABARAPL1 variant proteins: (A) LC3B-GABARAPL1 domain-swap variants in which hexameric blocks of diverged residues of LC3B were replaced with colinear ...
Chang-Yong Choi (3597962), Young Bong Choi (9915291), Mai Tram Vo (16557911)   +2 more
core   +1 more source

GABARAPL1 antibodies: Target one protein, get one free! [PDF]

Autophagy, 2011
Atg8 is a yeast protein involved in the autophagic process and in particular in the elongation of autophagosomes. In mammals, several orthologs have been identified and are classed into two subfamilies: the LC3 subfamily and the GABARAP subfamily, referred to simply as the LC3 or GABARAP families. GABARAPL1 (GABARAP-like protein 1), one of the proteins
Legrand, Jaclyn-Nicole, Chakrama, Fatima, Seguin-Py, Stéphanie, Fraichard, Annick, Delage-Mourroux, Regis, Jouvenot, Michele, Risold, Pierre-Yves, Boyer-Guittaut, Michael   +7 more
openaire   +3 more sources