Results 31 to 40 of about 4,298 (193)
Herpesvirus lytic infection-induced mitophagy via viral interferon regulatory factor 1
Autophagy Reports, 2023 Viral control of mitochondria via mitophagy has a dampening effect on mitochondrion-mediated innate immune responses. We previously found that human herpesvirus 8 (HHV-8) could activate mitophagy via its lytic gene product vIRF-1 (viral interferon ...
Mai Tram Vo, Young Bong Choi
doaj +1 more source
BMC Musculoskeletal Disorders, 2022 Steroid-induced osteonecrosis of femoral head (SANFH) involves impaired differentiation of bone marrow mesenchymal stem cells (BMSC), the mechanism of which is regulated by multiple microRNAs.
Pengfei Xu +6 more
doaj +1 more source
Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner [PDF]
, 2016 Bladder cancer (BC) is a common urologic tumor characterized by high risk of recurrence and mortality. Capsaicin (CPS), used as an intravesical drug for overactive bladder, was demonstrated to induce cell death in different cancer cells including BC ...
Amantini, C +6 more
core +1 more source
MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins [PDF]
, 2012 Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved catabolic process necessary for normal recycling of cellular constituents and for appropriate response to cellular stress.
Chiariello, Mario +8 more
core +1 more source
Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes [PDF]
, 2016 Autophagy is a highly coordinated process that is controlled at several levels including transcriptional regulation. Here, we identify the transcription factor NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2) as a regulator of autophagy gene expression ...
Cuadrado, Antonio +9 more
core +3 more sources
Targeting GABARAPL1/HIF-2a in nasopharyngeal carcinoma
, 2023 Abstract The primary gene mutations associated with nasopharyngeal carcinoma (NPC) are located within phosphoinositide 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling pathways. These pathways have inhibitory effects on autophagy, and autophagy has become an important area of NPC research.
Xiaopeng Huang +3 more
openaire +1 more source
Receptor proteins in selective autophagy [PDF]
, 2012 Autophagy has long been thought to be an essential but unselective bulk degradation pathway. However, increasing evidence suggests selective autophagosomal turnover of a broad range of substrates.
Behrends, Christian, Fulda, Simone
core +1 more source
HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses [PDF]
, 2018 BACKGROUND: Denervation triggers numerous molecular responses in skeletal muscle, including the activation of catabolic pathways and oxidative stress, leading to progressive muscle atrophy. Histone deacetylase 4 (HDAC4) mediates skeletal muscle response
Adamo, Sergio +7 more
core +1 more source
Inferring clonal evolution of tumors from single nucleotide somatic mutations [PDF]
, 2013 High-throughput sequencing allows the detection and quantification of frequencies of somatic single nucleotide variants (SNV) in heterogeneous tumor cell populations.
Deshwar, Amit G. +4 more
core +2 more sources
, 2014 Autophagy is an evolutionary conserved intracellular degradation and stress response mechanism that is mainly responsible for the breakdown and recycling of cytoplasmic materials, including long-lived proteins, protein aggregates, and damaged organelles.
Gozuacik, Devrim +3 more
core +1 more source