Results 31 to 40 of about 2,771 (143)

Herpesvirus lytic infection-induced mitophagy via viral interferon regulatory factor 1

Autophagy Reports, 2023
Viral control of mitochondria via mitophagy has a dampening effect on mitochondrion-mediated innate immune responses. We previously found that human herpesvirus 8 (HHV-8) could activate mitophagy via its lytic gene product vIRF-1 (viral interferon ...
Mai Tram Vo, Young Bong Choi
doaj   +1 more source

Insulin Inhibits Autophagy by Inhibiting the Binding of FoXO1 to the Promoter Region of GABARAPL1

Hormone and Metabolic Research, 2023
AbstractHyperinsulinemia and insulin resistance in T2D have a potent suppressive effect on hepatic autophagy, however, the underlying mechanisms remain unclear. To explore the effect of insulin on hepatic autophagy and its possible signaling pathways, HL-7702 cells were treated with insulin ...
Jie Wen, Tao Hong, Lang Mei, Ruixiang Li, Junlin Zhou, Jiaoyang Li, Xin-Hua Xiao   +6 more
openaire   +2 more sources

Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2 [PDF]

BioMed Research International, 2020
Background. Sevoflurane is commonly used as a general anesthetic in neonates to aged patients. Preconditioning or postconditioning with sevoflurane protects neurons from excitotoxic injury. Conversely, sevoflurane exposure induces neurotoxicity during early or late life.
Guolin Lu, Dongdong Rao, Min Zhou, null Liangpu Xu, Longxin Zhang, Sujing Zhang, Yuping Wang   +6 more
openaire   +2 more sources

MiR-145 inhibits the differentiation and proliferation of bone marrow stromal mesenchymal stem cells by GABARAPL1 in steroid-induced femoral head necrosis

BMC Musculoskeletal Disorders, 2022
Steroid-induced osteonecrosis of femoral head (SANFH) involves impaired differentiation of bone marrow mesenchymal stem cells (BMSC), the mechanism of which is regulated by multiple microRNAs.
Pengfei Xu, Jun Chang, Guangwen Ma, Faxue Liao, Tangbing Xu, Yunfeng Wu, Zongsheng Yin   +6 more
doaj   +1 more source

GABARAPL1 antibodies: Target one protein, get one free! [PDF]

Autophagy, 2011
Atg8 is a yeast protein involved in the autophagic process and in particular in the elongation of autophagosomes. In mammals, several orthologs have been identified and are classed into two subfamilies: the LC3 subfamily and the GABARAP subfamily, referred to simply as the LC3 or GABARAP families. GABARAPL1 (GABARAP-like protein 1), one of the proteins
Legrand, Jaclyn-Nicole, Chakrama, Fatima, Seguin-Py, Stéphanie, Fraichard, Annick, Delage-Mourroux, Regis, Jouvenot, Michele, Risold, Pierre-Yves, Boyer-Guittaut, Michael   +7 more
openaire   +3 more sources

TBK1 and GABARAP family members suppress Coxsackievirus B infection by limiting viral production and promoting autophagic degradation of viral extracellular vesicles.

PLoS Pathogens, 2022
Host-pathogen dynamics are constantly at play during enteroviral infection. Coxsackievirus B (CVB) is a common juvenile enterovirus that infects multiple organs and drives inflammatory diseases including acute pancreatitis and myocarditis.
Savannah Sawaged, Thomas Mota, Honit Piplani, Reetu Thakur, Deepti Lall, Elizabeth McCabe, Soojung Seo, Fayyaz S Sutterwala, Ralph Feuer, Roberta A Gottlieb, Jon Sin   +10 more
doaj   +1 more source

Targeting GABARAPL1/HIF-2a in nasopharyngeal carcinoma

, 2023
Abstract The primary gene mutations associated with nasopharyngeal carcinoma (NPC) are located within phosphoinositide 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling pathways. These pathways have inhibitory effects on autophagy, and autophagy has become an important area of NPC research.
Xiaopeng Huang, Liya Zhou, Jiawei Chen, Shuai Zhang   +3 more
openaire   +1 more source

Protective role of the Atg8 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease [PDF]

, 2021
Summary Diabetic heart disease is highly prevalent and characterized by diastolic dysfunction. The mechanisms of diabetic heart disease are poorly understood and no targeted therapies are available. Here we show that the diabetic myocardium (type 1 and type 2) is characterized by marked glycogen elevation and ectopic ...
Kimberley M. Mellor, Upasna Varma, Parisa Koutsifeli, Claire L. Curl, Johannes V. Janssens, Lorna J. Daniels, Gabriel B. Bernasochi, Antonia J.A. Raaijmakers, Victoria L. Benson, Eleia J. Chan, Marco Annandale, Xun Li, Yohanes Nursalim, Wendy T.K. Ip, David J. Taylor, Koen Raedschelders, Aleksandr Stotland, Aaron E. Robinson, Richard J. Mills, Regis R. Lamberts, Kim L. Powell, Terence J. O’Brien, Rajesh Katare, Chanchal Chandramouli, Rebecca H. Ritchie, Shiang Y. Lim, Robert G. Parton, Xinli Hu, James R. Bell, Enzo R. Porrello, James E. Hudson, Rui-Ping Xiao, Jennifer E. Van Eyk, Roberta A. Gottlieb, Lea M.D. Delbridge   +34 more
openaire   +1 more source

Identification of Hub Genes and Typing of Tuberculosis Infections Based on Autophagy-Related Genes

Polish Journal of Microbiology, 2023
Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the leading causes of morbidity and death in humans worldwide. Some autophagy genes associated with TB and some miRNAs regulating TB have been found, but the identification of autophagy ...
Sheng Yunfeng, Hua Haibo, Yong Yan, Zhou Lihong   +3 more
doaj   +1 more source

Dysfunctional energy and future perspective of low dose H2O2 as protective agent in neurodegenerative disease

Heliyon, 2023
The number of people with neurodegenerative disease continues to increase every year. A new perspective is needed to overcome this disease. In this review, researchers collected information about dysfunctional energy in neurodegenerative diseases driven ...
Sri Widyarti, Syahputra Wibowo, Akhmad Sabarudin, Intan Abhirama, Sutiman Bambang Sumitro   +4 more
doaj   +1 more source