Results 21 to 30 of about 2,771 (143)

GABARAP proteins regulate the packaging of HIV-1 genomic RNA into virions [PDF]

EMBO Reports
In addition to their role in canonical autophagy, autophagy proteins (ATG) contribute to various cellular processes, including phagocytosis, membrane remodeling, and vesicle secretion.
Marjory Palaric, Margaux Versapuech, Delphine Judith, Corentin Aubé, Marjorie Leduc, Jacques Dutrieux, Emilie-Fleur Gautier, Jean-Christophe Paillart, Sarah Gallois-Montbrun, Clarisse Berlioz-Torrent   +9 more
doaj   +2 more sources

Ceramide and the membrane-fusion activity of LC3/GABARAP autophagy proteins [PDF]

Cellular and Molecular Life Sciences
Macroautophagy is a cellular degradation process characterized by the formation of the double-membrane structure termed autophagosome (AP). The process of AP formation is not fully understood, but it is thought to happen through the combined action of ...
Yaiza R. Varela, Camila C. Aguirre, Marina N. Iriondo, Uxue Ballesteros, M. Isabel Collado, Asier Etxaniz, L. Ruth Montes, Felix M. Goñi, Alicia Alonso   +8 more
doaj   +2 more sources

Integrated Transcriptomic Analysis Identifies Immune Remodeling and Prognostic Signatures in Uveal Melanoma. [PDF]

Int J Genomics
Background Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults and exhibits a high propensity for liver metastasis, often leading to poor prognosis. However, effective prognostic biomarkers and therapeutic strategies for metastatic UVM remain limited.
Li Z, Yang Y, Wang H, Wang J.
europepmc   +2 more sources

Characterization of gene expression profiles in Alzheimer's disease and osteoarthritis: A bioinformatics study. [PDF]

PLoS ONE
BackgroundAlzheimer's disease (AD) and Osteoarthritis (OA) have been shown to have a close association in previous studies, but the pathogenesis of both diseases are unclear. This study explores the potential common molecular mechanisms between AD and OA
Nian Liu, Qian Deng, Zining Peng, Danning Mao, Yuanbo Huang, Fanyu Meng, Xiaoyu Zhang, Jiayan Shen, Zhaofu Li, Weitian Yan, Jiangyun Peng   +10 more
doaj   +2 more sources

Analysis of novel therapeutic targets and construction of a prognostic model for hepatocellular carcinoma [PDF]

PeerJ
Background The prognosis of patients with hepatocellular carcinoma (HCC) remains suboptimal due to limited biomarkers. Although ferroptosis and cuproptosis have emerged as promising therapeutic targets, their prognostic significance in HCC remains ...
Pengyuan Lei, Wenfeng Li, Dafei Xie, Hua Guan, Xin Huang, Bo Huang   +5 more
doaj   +3 more sources

Detection of Autophagy-Related Gene Expression by Conjunctival Impression Cytology in Age-Related Macular Degeneration

Diagnostics, 2021
Purpose: To investigate the association of autophagy-related gene expression with age-related macular degeneration (AMD). Methods: Patients with AMD were recruited for analysis by conjunctival impression cytology.
Chih-Wen Shu, Youn-Shen Bee, Jiunn-Liang Chen, Chui-Lien Tsen, Wei-Lun Tsai, Shwu-Jiuan Sheu   +5 more
doaj   +1 more source

The mitophagy receptor NIX induces vIRF-1 oligomerization and interaction with GABARAPL1 for the promotion of HHV-8 reactivation-induced mitophagy.

PLoS Pathogens, 2023
Recently, viruses have been shown to regulate selective autophagy for productive infections. For instance, human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), activates selective autophagy of mitochondria, termed ...
Mai Tram Vo, Chang-Yong Choi, Young Bong Choi   +2 more
doaj   +1 more source

Bi-allelic ATG4D variants are associated with a neurodevelopmental disorder characterized by speech and motor impairment

npj Genomic Medicine, 2023
Autophagy regulates the degradation of damaged organelles and protein aggregates, and is critical for neuronal development, homeostasis, and maintenance, yet few neurodevelopmental disorders have been associated with pathogenic variants in genes encoding
Marie Morimoto, Vikas Bhambhani, Nour Gazzaz, Mariska Davids, Paalini Sathiyaseelan, Ellen F. Macnamara, Jennifer Lange, Anna Lehman, Patricia M. Zerfas, Jennifer L. Murphy, Maria T. Acosta, Camille Wang, Emily Alderman, Undiagnosed Diseases Network, Sara Reichert, Audrey Thurm, David R. Adams, Wendy J. Introne, Sharon M. Gorski, Cornelius F. Boerkoel, William A. Gahl, Cynthia J. Tifft, May Christine V. Malicdan   +22 more
doaj   +1 more source

Induction of the expression of GABARAPL1 by hydrogen peroxide in C6 glioma cells [PDF]

Integrative Molecular Medicine, 2015
Ischemia-reperfusion or traumatic brain injury induces the accumulation of reactive oxygen species (ROS) in brain. ROS causes oxidative stress to astrocytes as well as neurons and oxidative stress induces the damage to organelles, proteins or lipids.
Hiromi Nochi, Yoshimitsu Kiriyama, Kunihiko Kasai, Katsuhito Kino   +3 more
openaire   +1 more source

Cytoprotective autophagy induction by withaferin A in prostate cancer cells involves GABARAPL1 [PDF]

Molecular Carcinogenesis, 2020
AbstractWithaferin A (WA) is a naturally occurring steroidal lactone with proven cancer chemopreventive activity in preclinical models of different cancers including prostate adenocarcinoma. Previously we compared the RNA‐seq data from control and WA‐treated 22Rv1 human prostate cancer cells to identify mechanistic targets of this phytochemical.
Eun‐Ryeong Hahm, Shivendra V. Singh
openaire   +2 more sources