Results 21 to 30 of about 4,298 (193)

Ceramide and the membrane-fusion activity of LC3/GABARAP autophagy proteins [PDF]

Cellular and Molecular Life Sciences
Macroautophagy is a cellular degradation process characterized by the formation of the double-membrane structure termed autophagosome (AP). The process of AP formation is not fully understood, but it is thought to happen through the combined action of ...
Yaiza R. Varela, Camila C. Aguirre, Marina N. Iriondo, Uxue Ballesteros, M. Isabel Collado, Asier Etxaniz, L. Ruth Montes, Felix M. Goñi, Alicia Alonso   +8 more
doaj   +2 more sources

Characterization of gene expression profiles in Alzheimer's disease and osteoarthritis: A bioinformatics study. [PDF]

PLoS ONE
BackgroundAlzheimer's disease (AD) and Osteoarthritis (OA) have been shown to have a close association in previous studies, but the pathogenesis of both diseases are unclear. This study explores the potential common molecular mechanisms between AD and OA
Nian Liu, Qian Deng, Zining Peng, Danning Mao, Yuanbo Huang, Fanyu Meng, Xiaoyu Zhang, Jiayan Shen, Zhaofu Li, Weitian Yan, Jiangyun Peng   +10 more
doaj   +2 more sources

Analysis and identification of ferroptosis-related diagnostic markers in rheumatoid arthritis [PDF]

Annals of Medicine
Background Rheumatoid arthritis (RA) is an autoimmune, inflammatory joint disease. There is growing evidence that ferroptosis is involved in the pathogenesis of RA. This study aimed to search for diagnostic markers of ferroptosis in RA and to analyse the
Yang Cai, Lingchuan Deng, Jun Yao
doaj   +2 more sources

Analysis of novel therapeutic targets and construction of a prognostic model for hepatocellular carcinoma [PDF]

PeerJ
Background The prognosis of patients with hepatocellular carcinoma (HCC) remains suboptimal due to limited biomarkers. Although ferroptosis and cuproptosis have emerged as promising therapeutic targets, their prognostic significance in HCC remains ...
Pengyuan Lei, Wenfeng Li, Dafei Xie, Hua Guan, Xin Huang, Bo Huang   +5 more
doaj   +3 more sources

Construction and evaluation of a prognostic model of autophagy-related genes in hepatocellular carcinoma [PDF]

Biochemistry and Biophysics Reports
Background: Hepatocellular carcinoma (HCC) is a globally prevalent disease. Our article evaluates risk models based on autophagy- and HCC-related genes and their prognostic value by bioinformatics analytical methods to provide a scientific basis for ...
Yutao He, Bin Du, Weiran Liao, Wei Wang, Jifeng Su, Chen Guo, Kai Zhang, Zhitian Shi   +7 more
doaj   +2 more sources

Detection of Autophagy-Related Gene Expression by Conjunctival Impression Cytology in Age-Related Macular Degeneration

Diagnostics, 2021
Purpose: To investigate the association of autophagy-related gene expression with age-related macular degeneration (AMD). Methods: Patients with AMD were recruited for analysis by conjunctival impression cytology.
Chih-Wen Shu, Youn-Shen Bee, Jiunn-Liang Chen, Chui-Lien Tsen, Wei-Lun Tsai, Shwu-Jiuan Sheu   +5 more
doaj   +1 more source

The mitophagy receptor NIX induces vIRF-1 oligomerization and interaction with GABARAPL1 for the promotion of HHV-8 reactivation-induced mitophagy.

PLoS Pathogens, 2023
Recently, viruses have been shown to regulate selective autophagy for productive infections. For instance, human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), activates selective autophagy of mitochondria, termed ...
Mai Tram Vo, Chang-Yong Choi, Young Bong Choi   +2 more
doaj   +1 more source

GABARAPL1 antibodies: Target one protein, get one free! [PDF]

Autophagy, 2011
Atg8 is a yeast protein involved in the autophagic process and in particular in the elongation of autophagosomes. In mammals, several orthologs have been identified and are classed into two subfamilies: the LC3 subfamily and the GABARAP subfamily, referred to simply as the LC3 or GABARAP families. GABARAPL1 (GABARAP-like protein 1), one of the proteins
Legrand, Jaclyn-Nicole, Chakrama, Fatima, Seguin-Py, Stéphanie, Fraichard, Annick, Delage-Mourroux, Regis, Jouvenot, Michele, Risold, Pierre-Yves, Boyer-Guittaut, Michael   +7 more
openaire   +3 more sources

Bi-allelic ATG4D variants are associated with a neurodevelopmental disorder characterized by speech and motor impairment

npj Genomic Medicine, 2023
Autophagy regulates the degradation of damaged organelles and protein aggregates, and is critical for neuronal development, homeostasis, and maintenance, yet few neurodevelopmental disorders have been associated with pathogenic variants in genes encoding
Marie Morimoto, Vikas Bhambhani, Nour Gazzaz, Mariska Davids, Paalini Sathiyaseelan, Ellen F. Macnamara, Jennifer Lange, Anna Lehman, Patricia M. Zerfas, Jennifer L. Murphy, Maria T. Acosta, Camille Wang, Emily Alderman, Undiagnosed Diseases Network, Sara Reichert, Audrey Thurm, David R. Adams, Wendy J. Introne, Sharon M. Gorski, Cornelius F. Boerkoel, William A. Gahl, Cynthia J. Tifft, May Christine V. Malicdan   +22 more
doaj   +1 more source

Cytoprotective autophagy induction by withaferin A in prostate cancer cells involves GABARAPL1 [PDF]

Molecular Carcinogenesis, 2020
AbstractWithaferin A (WA) is a naturally occurring steroidal lactone with proven cancer chemopreventive activity in preclinical models of different cancers including prostate adenocarcinoma. Previously we compared the RNA‐seq data from control and WA‐treated 22Rv1 human prostate cancer cells to identify mechanistic targets of this phytochemical.
Eun‐Ryeong Hahm, Shivendra V. Singh
openaire   +2 more sources