Glycophagy is an ancient bilaterian pathway supporting metabolic adaptation through STBD1 structural evolution [PDF]
Communications BiologyGlycophagy, a selective form of autophagy critical for glycogen homeostasis, relies on the glycogen cargo receptor called starch-binding domain-containing protein 1 (STBD1), yet its evolutionary origins remain elusive.
Chenyu Shi +2 more
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Asiatic Acid Alleviates Renal Damage by Upregulating STBD1-Mediated Glycophagy in Diabetic Kidney Disease [PDF]
BiomedicinesBackground/Objectives: The role of glycogen metabolism in diabetic kidney disease (DKD) remains unclear. This study investigated the therapeutic potential of asiatic acid (AA) on glycogen metabolism in DKD and its underlying mechanisms.
Peili Wu, Qianjin Feng, Wu Peili
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Decoding the molecular mechanism of selective autophagy of glycogen mediated by autophagy receptor STBD1 [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaAutophagy of glycogen (glycophagy) is crucial for the maintenance of cellular glucose homeostasis and physiology in mammals. STBD1 can serve as an autophagy receptor to mediate glycophagy by specifically recognizing glycogen and relevant key autophagic factors, but with poorly understood mechanisms. Here, we systematically characterize the interactions
Yuchao Zhang, Peng Xu, Yingli Wang
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Stbd1 stimulates AMPK signaling and alleviates insulin resistance in an in vitro hepatocyte model [PDF]
FEBS JournalStarch‐binding domain‐containing protein 1 (Stbd1) is a glycogen‐binding protein which localizes to the endoplasmic reticulum (ER) membrane and ER‐mitochondria contact sites (ERMCs). The protein undergoes N ‐myristoylation, which is a major determinant of its subcellular targeting.
Thilo Speckmann +2 more
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Glycophagy: molecular mechanisms, regulatory signals, and disease associations [PDF]
Autophagy ReportsGlycophagy is a process of selective degradation of glycogen through the autophagy pathway. It relies on key proteins, such as STBD1 (glycogen-specific autophagy receptor), GABARAPL1 (member of the ATG8 family), and acid α-glucosidase (GAA), and proceeds
Jinyong Jiang
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STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma
Cell ReportsSummary: The accumulation of lipid droplets (LDs) and glycogen is a major hallmark of clear cell renal cell carcinoma (ccRCC), yet their interplay remains unclear.
Hao Wang +15 more
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Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1 [PDF]
Biochemical and Biophysical Research Communications, 2011 Glycogen, a branched polymer of glucose, acts as an intracellular carbon and energy reserve in many tissues and cell types. An important pathway for its degradation is by transport to lysosomes in an autophagy-like process. It has been proposed that starch-binding domain-containing protein 1 (Stbd1) may participate in this mechanism by anchoring ...
Clark D Wells, Peter J Roach
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Biochimie, 2022 Starch binding domain-containing protein 1 (STBD1) is an endoplasmic reticulum (ER)-resident, glycogen-binding protein. In addition to glycogen, STBD1 has been shown to interact with several proteins implicated in glycogen synthesis and degradation, yet its function in glycogen metabolism remains largely unknown.
Fabian Schumacher +2 more
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The carbohydrate-binding domain of overexpressed STBD1 is important for its stability and protein–protein interactions [PDF]
Bioscience Reports, 2014 STBD1 (starch-binding domain-containing protein 1) belongs to the CBM20 (family 20 carbohydrate binding module) group of proteins, and is implicated in glycogen metabolism and autophagy. However, very little is known about its regulation or interacting partners.
Mei Zhang, Zhu Yuanqi, Zhang Mei
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Stbd1 promotes glycogen clustering during endoplasmic reticulum stress and supports survival of mouse myoblasts [PDF]
Journal of Cell Science, 2020 ABSTRACT Imbalances in endoplasmic reticulum (ER) homeostasis provoke a condition known as ER stress and activate the unfolded protein response (UPR) pathway, an evolutionarily conserved cell survival mechanism. Here, we show that mouse myoblasts respond to UPR activation by stimulating glycogenesis and the formation of α-amylase ...
Louiza Potamiti +2 more
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