Results 1 to 10 of about 1,264 (145)

Glycophagy is an ancient bilaterian pathway supporting metabolic adaptation through STBD1 structural evolution [PDF]

Communications Biology
Glycophagy, a selective form of autophagy critical for glycogen homeostasis, relies on the glycogen cargo receptor called starch-binding domain-containing protein 1 (STBD1), yet its evolutionary origins remain elusive.
Liting Ren, Yitian Bai, Chenyu Shi, Zhengwang Hao, Qi Li, Daniel J. Macqueen, Shikai Liu   +6 more
exaly   +8 more sources

Stbd1 stimulates AMPK signaling and alleviates insulin resistance in an in vitro hepatocyte model [PDF]

FEBS Journal
Stbd1 is an N‐myristoylated, ER‐resident, glycogen‐binding protein whose loss‐of‐function has been associated with insulin resistance. We report that AML12 hepatocytes overexpressing either N‐myristoylated Stbd1 or a non‐N‐myristoylated variant display enhanced AMPK signaling and improved insulin sensitivity, independently of differences in glycogen ...
Petros P Petrou, Mihalis Ι Panayiotidis
exaly   +6 more sources

Asiatic Acid Alleviates Renal Damage by Upregulating STBD1-Mediated Glycophagy in Diabetic Kidney Disease [PDF]

Biomedicines
Background/Objectives: The role of glycogen metabolism in diabetic kidney disease (DKD) remains unclear. This study investigated the therapeutic potential of asiatic acid (AA) on glycogen metabolism in DKD and its underlying mechanisms.
Lei Guo, Peili Wu, Qijian Feng, Xiaochun Lin, Yuan Wang, Minghai Wu, Feifei Cai, Jin Zhang, Chuyi Yang, Xuelin Li, Churan Wen, Yingbei Lin, Nannan Liu, Yuxuan Hu, Huiyun Wang, Xinzhao Fan, Meiping Guan   +16 more
exaly   +6 more sources

Stbd1-deficient mice display insulin resistance associated with enhanced hepatic ER-mitochondria contact [PDF]

Biochimie, 2022
Starch binding domain-containing protein 1 (STBD1) is an endoplasmic reticulum (ER)-resident, glycogen-binding protein. In addition to glycogen, STBD1 has been shown to interact with several proteins implicated in glycogen synthesis and degradation, yet its function in glycogen metabolism remains largely unknown.
Louiza Potamiti, Fabian Schumacher, Burkhard Kleuser   +2 more
exaly   +7 more sources

Decoding the molecular mechanism of selective autophagy of glycogen mediated by autophagy receptor STBD1 [PDF]

Proceedings of the National Academy of Sciences of the United States of America
Autophagy of glycogen (glycophagy) is crucial for the maintenance of cellular glucose homeostasis and physiology in mammals. STBD1 can serve as an autophagy receptor to mediate glycophagy by specifically recognizing glycogen and relevant key autophagic factors, but with poorly understood mechanisms. Here, we systematically characterize the interactions
yuchao zhang, Peng Xu, Yingli Wang
exaly   +6 more sources

Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates [PDF]

Cellular Signalling, 2019
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis, acting as a sensor of energy and nutrient status. As such, AMPK is considered a promising drug target for treatment of medical conditions particularly associated with metabolic dysfunctions. To better understand the downstream effectors and physiological consequences
Serge Ducommun, Anja Zeigerer, Olga Goransson   +2 more
exaly   +9 more sources

STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma

Cell Reports
Summary: The accumulation of lipid droplets (LDs) and glycogen is a major hallmark of clear cell renal cell carcinoma (ccRCC), yet their interplay remains unclear.
Ruibing Chen
exaly   +5 more sources

Glycophagy: molecular mechanisms, regulatory signals, and disease associations [PDF]

Autophagy Reports
Glycophagy is a process of selective degradation of glycogen through the autophagy pathway. It relies on key proteins, such as STBD1 (glycogen-specific autophagy receptor), GABARAPL1 (member of the ATG8 family), and acid α-glucosidase (GAA), and proceeds
Lei Chen, Jinyong Jiang, Meiqing Liu, Linxi Chen   +3 more
exaly   +5 more sources

Stbd1 promotes glycogen clustering during endoplasmic reticulum stress and supports survival of mouse myoblasts [PDF]

Journal of Cell Science, 2020
ABSTRACT Imbalances in endoplasmic reticulum (ER) homeostasis provoke a condition known as ER stress and activate the unfolded protein response (UPR) pathway, an evolutionarily conserved cell survival mechanism. Here, we show that mouse myoblasts respond to UPR activation by stimulating glycogenesis and the formation of α-amylase ...
Louiza Potamiti, Kyriacos Kyriacou, Leonidas Phylactou   +2 more
exaly   +4 more sources

Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1 [PDF]

Biochemical and Biophysical Research Communications, 2011
Glycogen, a branched polymer of glucose, acts as an intracellular carbon and energy reserve in many tissues and cell types. An important pathway for its degradation is by transport to lysosomes in an autophagy-like process. It has been proposed that starch-binding domain-containing protein 1 (Stbd1) may participate in this mechanism by anchoring ...
Sixin, Jiang, Clark D, Wells, Peter J, Roach   +2 more
exaly   +4 more sources