Results 11 to 20 of about 1,264 (145)

The carbohydrate-binding domain of overexpressed STBD1 is important for its stability and protein–protein interactions [PDF]

Bioscience Reports, 2014
STBD1 (starch-binding domain-containing protein 1) belongs to the CBM20 (family 20 carbohydrate binding module) group of proteins, and is implicated in glycogen metabolism and autophagy. However, very little is known about its regulation or interacting partners.
Mei Zhang, Alan Cheng
exaly   +6 more sources

Mouse Stbd1 is N-myristoylated and affects ER–mitochondria association and mitochondrial morphology [PDF]

Journal of Cell Science, 2017
ABSTRACT Starch binding domain-containing protein 1 (Stbd1) is a carbohydrate-binding protein that has been proposed to be a selective autophagy receptor for glycogen. Here, we show that mouse Stbd1 is a transmembrane endoplasmic reticulum (ER)-resident protein with the capacity to induce the formation of organized ER structures in HeLa ...
Anthi Demetriadou, Julia Morales-Sanfrutos, Marianna Nearchou, Otto Baba, Kyriacos Kyriacou, Edward W. Tate, Anthi Drousiotou, Petros P. Petrou   +7 more
semanticscholar   +8 more sources

A two-stage meta-analysis identifies several new loci for Parkinson's disease. [PDF]

PLoS Genetics, 2011
A previous genome-wide association (GWA) meta-analysis of 12,386 PD cases and 21,026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci.
International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2)   +1 more
doaj   +7 more sources

Glycophagy is involved in cardiac glycogen regulation in response to exercise [PDF]

Current Research in Physiology
Cardiac glycogen-autophagy (‘glycophagy’) is disturbed in cardiometabolic pathologies. The physiological role of cardiac glycophagy is unclear. Exercise induces transient cardiac glycogen accumulation.
Samuel L. James, Parisa Koutsifeli, Randall F. D'Souza, Stewart WC. Masson, Jonathan ST. Woodhead, Troy L. Merry, Lea MD. Delbridge, Kimberley M. Mellor   +7 more
doaj   +3 more sources

Methods for detection of cardiac glycogen-autophagy [PDF]

Autophagy Reports
Glycogen-autophagy (‘glycophagy’) is a selective autophagy process involved in delivering glycogen to the lysosome for bulk degradation. Glycophagy protein intermediaries include STBD1 as a glycogen tagging receptor, delivering the glycogen cargo into ...
Parisa Koutsifeli, Lorna J. Daniels, Joshua Neale, Sarah Fong, Upasna Varma, Marco Annandale, Xun Li, Yohanes Nursalim, James R. Bell, Kate L. Weeks, Aleksandr Stotland, David J. Taylor, Roberta A. Gottlieb, Lea M.D. Delbridge, Kimberley M. Mellor   +14 more
doaj   +4 more sources

Clinical and Metabolic Signatures of FAM47E–SHROOM3 Haplotypes in a General Population Sample [PDF]

Kidney International Reports
Introduction: Genome-wide association studies (GWAS) identified a locus on chromosome 4q21.1, spanning the Family With Sequence Similarity 47 Member E (FAM47E), Starch Binding Domain 1 (STBD1), Coiled-Coil Domain Containing 158 (CCDC158), and Shroom ...
Dariush Ghasemi-Semeskandeh, Eva König, Luisa Foco, Nikola Dordevic, Martin Gögele, Johannes Rainer, Markus Ralser, Dianne Acoba, Francisco S. Domingues, Dorien J.M. Peters, Peter P. Pramstaller, Cristian Pattaro   +11 more
doaj   +3 more sources

Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens [PDF]

Cells, 2022
As a predominant hormone in the reproductive axis, follicle-stimulating hormone (FSH) is known as the primary surviving factor for follicular growth. In this study, the alleviating effect of FSH on aging chicken granulosa cells (GCs) was investigated ...
Juan Dong, Changquan Guo, Zhaoyu Yang, Yangyang Wu, Caiqiao Zhang   +4 more
doaj   +3 more sources

Model-based analysis uncovers mutations altering autophagy selectivity in human cancer. [PDF]

Nat Commun, 2021
Autophagy can selectively target protein aggregates, pathogens, and dysfunctional organelles for the lysosomal degradation. Aberrant regulation of autophagy promotes tumorigenesis, while it is far less clear whether and how tumor-specific alterations ...
Han Z, Zhang W, Ning W, Wang C, Deng W, Li Z, Shang Z, Shen X, Liu X, Baba O, Morita T, Chen L, Xue Y, Jia D.   +13 more
europepmc   +8 more sources

Stbd1 is highly elevated in skeletal muscle of Pompe disease mice but suppression of its expression does not affect lysosomal glycogen accumulation [PDF]

Molecular Genetics and Metabolism, 2013
Previous studies strongly suggest that starch binding domain containing protein 1 (Stbd1) plays an important role in intracellular glycogen trafficking into lysosomes. We report here that Stbd1 expression is markedly increased in skeletal muscles but not in heart and liver of GAA-KO mice.
Haiqing Yi, Baodong Sun, Priya S Kishnani   +2 more
exaly   +4 more sources

iCAL: a new pipeline to investigate autophagy selectivity and cancer [PDF]

Autophagy, 2021
Macroautophagy/autophagy can selectively degrade misfolded proteins, damaged organelles and other cargoes. It is conceivable that alteration of the degradation processes could disrupt normal cellular signaling and contribute to human diseases such as ...
Weizhi Zhang, Yu Xue, Da Jia
exaly   +3 more sources