Glycophagy is involved in cardiac glycogen regulation in response to exercise [PDF]
Current Research in PhysiologyCardiac glycogen-autophagy (‘glycophagy’) is disturbed in cardiometabolic pathologies. The physiological role of cardiac glycophagy is unclear. Exercise induces transient cardiac glycogen accumulation.
Samuel L. James +7 more
doaj +3 more sources
Stbd1 is highly elevated in skeletal muscle of Pompe disease mice but suppression of its expression does not affect lysosomal glycogen accumulation [PDF]
Molecular Genetics and Metabolism, 2013 Previous studies strongly suggest that starch binding domain containing protein 1 (Stbd1) plays an important role in intracellular glycogen trafficking into lysosomes. We report here that Stbd1 expression is markedly increased in skeletal muscles but not in heart and liver of GAA-KO mice.
Haiqing Yi +2 more
exaly +4 more sources
Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates [PDF]
Cellular Signalling, 2019 AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis, acting as a sensor of energy and nutrient status. As such, AMPK is considered a promising drug target for treatment of medical conditions particularly associated with metabolic dysfunctions. To better understand the downstream effectors and physiological consequences
Serge Ducommun +2 more
exaly +6 more sources
Methods for detection of cardiac glycogen-autophagy [PDF]
Autophagy ReportsGlycogen-autophagy (‘glycophagy’) is a selective autophagy process involved in delivering glycogen to the lysosome for bulk degradation. Glycophagy protein intermediaries include STBD1 as a glycogen tagging receptor, delivering the glycogen cargo into ...
Parisa Koutsifeli +14 more
doaj +5 more sources
Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens [PDF]
Cells, 2022 As a predominant hormone in the reproductive axis, follicle-stimulating hormone (FSH) is known as the primary surviving factor for follicular growth. In this study, the alleviating effect of FSH on aging chicken granulosa cells (GCs) was investigated ...
Juan Dong +4 more
doaj +3 more sources
Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes and Proteins with Functions in Cancer Cell Biology and Glycogen Metabolism [PDF]
Molecules, 2020 Clear cell foci (CCF) of the liver are considered to be pre-neoplastic lesions of hepatocellular adenomas and carcinomas. They are hallmarked by glycogen overload and activation of AKT (v-akt murine thymoma viral oncogene homolog)/mTOR (mammalian target ...
Christoph Metzendorf +10 more
doaj +4 more sources
A two-stage meta-analysis identifies several new loci for Parkinson's disease. [PDF]
PLoS Genetics, 2011 A previous genome-wide association (GWA) meta-analysis of 12,386 PD cases and 21,026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci.
International Parkinson's Disease Genomics Consortium (IPDGC) +1 more
doaj +8 more sources
Mouse Stbd1 is N-myristoylated and affects ER–mitochondria association and mitochondrial morphology [PDF]
Journal of Cell Science, 2017 ABSTRACT Starch binding domain-containing protein 1 (Stbd1) is a carbohydrate-binding protein that has been proposed to be a selective autophagy receptor for glycogen. Here, we show that mouse Stbd1 is a transmembrane endoplasmic reticulum (ER)-resident protein with the capacity to induce the formation of organized ER structures in HeLa ...
Anthi Demetriadou +7 more
openaire +4 more sources
The “sweet” side of ER-mitochondria contact sites
Communicative & Integrative Biology, 2017 The regions at which the ER and mitochondria come into close proximity, known as ER-mitochondria contact sites provide essential platforms for the exchange of molecules between the two organelles and the coordination of various fundamental cellular ...
Anthi Demetriadou +2 more
doaj +2 more sources
Development of GABARAP family protein-sensitive LIR-based probes for neuronal autophagy
Molecular Brain, 2019 Autophagy allows for lysosomal cellular degradation of cytosolic components. In particular, neuronal autophagy is essential for cellular homeostasis and neuronal survival and is tightly regulated by several autophagy-related (ATG) proteins in post ...
Pureum Jeon +5 more
doaj +2 more sources