Results 21 to 30 of about 1,264 (145)

Genetics of Neurogenic Orthostatic Hypotension in Parkinson’s Disease, Results from a Cross-Sectional In Silico Study

Brain Sciences, 2023
The genetic basis of Neurogenic Orthostatic Hypotension (NOH) in Parkinson’s disease (PD) has been inadequately explored. In a cross-sectional study, we examined the association between NOH and PD-related single-nucleotide polymorphisms (SNPs) and mapped
Guenson Chevalier, Lucas Udovin, Matilde Otero-Losada, Sofia Bordet, Francisco Capani, Sheng Luo, Christopher G. Goetz, Santiago Perez-Lloret   +7 more
doaj   +2 more sources

New Toolset of Reporters Reveals That Glycogen Granules Are Neutral Substrates of Bulk Autophagy in <i>Komagataella phaffii</i>. [PDF]

Int J Mol Sci
Glycogen, a branched polysaccharide organized into glycogen granules (GGs), is delivered from the cytoplasm to the lysosomes of hepatocytes by STBD1-driven selective autophagy (glycophagy).
Wijewantha NV, Battu P, Chen K, Kumar R, Nazarko TY.   +4 more
europepmc   +2 more sources

Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes and Proteins with Functions in Cancer Cell Biology and Glycogen Metabolism

Molecules, 2020
Clear cell foci (CCF) of the liver are considered to be pre-neoplastic lesions of hepatocellular adenomas and carcinomas. They are hallmarked by glycogen overload and activation of AKT (v-akt murine thymoma viral oncogene homolog)/mTOR (mammalian target ...
Christoph Metzendorf, Katharina Wineberger, Jenny Rausch, Antonio Cigliano, Kristin Peters, Baodong Sun, Daniela Mennerich, Thomas Kietzmann, Diego F. Calvisi, Frank Dombrowski, Silvia Ribback   +10 more
doaj   +2 more sources

Development of GABARAP family protein-sensitive LIR-based probes for neuronal autophagy

Molecular Brain, 2019
Autophagy allows for lysosomal cellular degradation of cytosolic components. In particular, neuronal autophagy is essential for cellular homeostasis and neuronal survival and is tightly regulated by several autophagy-related (ATG) proteins in post ...
Pureum Jeon, Ju-Hui Park, Yong-Woo Jun, You-Kyung Lee, Deok-Jin Jang, Jin-A Lee   +5 more
doaj   +2 more sources

Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib [PDF]

Molecular Metabolism
Objective: Carbohydrate Response Element Binding Protein (ChREBP) is a glucose 6-phosphate (G6P)-sensitive transcription factor that acts as a metabolic switch to maintain intracellular glucose and phosphate homeostasis.
K.A. Krishnamurthy, M.G.S. Rutten, J.A. Hoogerland, T.H. van Dijk, T. Bos, M. Koehorst, M.P. de Vries, N.J. Kloosterhuis, H. Havinga, B.V. Schomakers, M. van Weeghel, J.C. Wolters, B.M. Bakker, M.H. Oosterveer   +13 more
doaj   +2 more sources

Starch Binding Domain-containing Protein 1 Plays a Dominant Role in Glycogen Transport to Lysosomes in Liver

Journal of Biological Chemistry, 2016
A small portion of cellular glycogen is transported to and degraded in lysosomes by acid α-glucosidase (GAA) in mammals, but it is unclear why and how glycogen is transported to the lysosomes.
Haiqing Yi, Baodong Sun, Priya S Kishnani   +2 more
exaly   +2 more sources

Starch Binding Domain-containing Protein 1/Genethonin 1 Is a Novel Participant in Glycogen Metabolism

Journal of Biological Chemistry, 2010
Stbd1 is a protein of previously unknown function that is most prevalent in liver and muscle, the major sites for storage of the energy reserve glycogen.
Vincent S Tagliabracci, Anna DePaoli-roach   +1 more
exaly   +2 more sources

Genetic association study between STK39 and CCDC62/HIP1R and Parkinson's disease [PDF]

, 2013
10.1371/journal.pone.0079211PLoS ONE811 ...
Chang, X.-L., Li, N.-N., Liao, Q., Mao, X.-Y., Peng, R., Tan, E.-K., Yu, W.-J., Zhang, J.-H., Zhao, D.-M.   +8 more
core   +10 more sources

Transcriptomic and proteomic studies of condylar ossification of the temporomandibular joint in porcine embryos

Animal Models and Experimental Medicine, Volume 6, Issue 4, Page 294-305, August 2023., 2023
In this study, 15 differential genes which associated with bone development, regeneration and pathogenesis of osteoarthritis through literature reading were selected for QPCR verification. The up‐regulation or down‐regulation trend of 14 candidate genes was consistent with the results of transcriptome sequencing.
Lei Xiang, Yongfeng Li, Xuewen Wang, HuaWei Liu, Ping Chang, Xiaodan Mu, Tengyue Tianteng, Min Hu   +7 more
wiley   +1 more source

Targeting the Lysosomal Degradation of Rab22a‐NeoF1 Fusion Protein for Osteosarcoma Lung Metastasis

Advanced Science, Volume 10, Issue 5, February 14, 2023., 2023
In osteosarcoma cells, Rab22a‐NeoF1 fusion protein can be polyubiquitinated at lysine112 via the K63‐linked ubiquitin chains and then be recognized by autophagy receptor NDP52, leading to the lysosomal degradation of Rab22a‐NeoF1. This process is promoted by PINK1 kinase via phosphorylating Rab22a‐NeoF1 at serine120, and Sorafenib and Regorafenib can ...
Cuiling Zeng, Li Zhong, Wenqiang Liu, Yu Zhang, Xinhao Yu, Xin Wang, Ruhua Zhang, Tiebang Kang, Dan Liao   +8 more
wiley   +1 more source