Results 41 to 50 of about 854 (122)

DAMP Laden Extracellular Vesicles From the Airways of Patients With Severe SARS‐CoV‐2 Respiratory Infection Compromise Inflammation and Cellular Metabolism

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Extracellular vesicles from severe COVID‐19 airways carry depleted miRNAs and elevated DAMPs, reprogramming monocytes toward senescence, impaired metabolism, and predominantly reduced cytokine responses. However, they drive excess IL‐8 production, amplifying neutrophil recruitment and dysfunctional inflammation across the respiratory tract.
April Rees, Oliver Richards, Molly E Raikes, Megan Chambers, Sophie G Reed, Ceri Battle, Hannah Toghill, Luke Newey, Tyler J Joseph, Haiyan An, Hui Zhang, Iain Perry, Jason Webber, Nicholas Jones, Catherine A Thornton   +14 more
wiley   +1 more source

Comparative multi‐omics in female mice reveals tissue‐specific vulnerabilities to chronic alcohol intake

Alcohol, Clinical and Experimental Research, Volume 50, Issue 2, February 2026.
Using mice, we applied multi‐omics to compare liver and skeletal muscle after chronic alcohol consumption. The liver responded more strongly across genes, proteins, and metabolites, with a lowered PC:PE ratio. Muscle showed inflammation, extracellular matrix activation, impaired mitochondrial energetics, and an elevated PC:PE ratio. Lipidomics affected
Craig R. G. Willis, Muni Swamy Ganjayi, Austin M. Brown, Samantha E. Moser, Nathaniel J. Szewczyk, Brian C. Clark, Cory W. Baumann   +6 more
wiley   +1 more source

The Subgingival Host–Microbial Landscape in Mothers With Periodontitis and Their At‐Risk Offspring

Journal of Clinical Periodontology, Volume 53, Issue 2, Page 201-213, February 2026.
ABSTRACT Aim To evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases. Methods Forty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring.
Hélvis E. S. Paz, Camila S. Stolf, Kai Bao, Mabelle F. Monteiro, Lucas M. Carvalho, Angelika Silbereisen, Georgios N. Belibasakis, Renato C. V. Casarin, Nagihan Bostanci   +8 more
wiley   +1 more source

Starch-binding domain-containing protein 1: a novel participant in glycogen metabolism

, 2011
Indiana University-Purdue University Indianapolis (IUPUI)Glycogen, a branched polymer of glucose, acts as an intracellular carbon and energy reserve in many tissues and cell types.
Jiang, Sixin
core   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, Volume 182, Issue 19, Page 4625-4646, October 2025.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source

Transcriptome Analysis of Bovine Ovarian Follicles at Predeviation and Onset of Deviation Stages of a Follicular Wave

International Journal of Genomics, Volume 2016, Issue 1, 2016., 2016
For two libraries (PDF1 and ODF1) using Illumina sequencing 44,082,301 and 43,708,132 clean reads were obtained, respectively. After being mapped to the bovine RefSeq database, 15,533 genes were identified to be expressed in both types of follicles (cut‐off RPKM > 0.5), of which 719 were highly expressed in bovine follicles (cut‐off RPKM > 100 ...
Pengfei Li, Jinzhu Meng, Wenzhong Liu, George W. Smith, Jianbo Yao, Lihua Lyu, Ferenc Olasz   +6 more
wiley   +1 more source

Integrative bulk and single-cell transcriptome analyses reveal RNA modification–related biomarkers of spinal cord injury

Neural Regeneration Research
Aberrant RNA modification has been linked to the pathogenesis of various diseases; however, its specific molecular mechanisms in spinal cord injury remain poorly understood.
Shixue Huang, Kun Jiao, Keqing Li, Jiayan Yuan, Haoming Shu, Yinuo Zhang, Xin Zhou, Xuhui Zhou   +7 more
doaj   +1 more source

Genome‐wide study links cardiometabolic factors to cognition via APOA4‐APOA5‐ZPR1‐BUD13 and other loci in rural Indians

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION Cardiometabolic risks affect cognition during aging, yet genetic basis for both remain understudied in Indians. METHODS This study constructs an ancestry‐matched Indian haplotype reference panel for genotype imputation of 5111 rural Indians. Single‐locus, gene‐based, conditional genome‐wide association analyses are performed on 20
Shreya Chakraborty, Krithika Subramanian, Akkshaya Rajesh, Rupanwita Majumder, Khader Valli Rupanagudi, Abhishek Mensegere, TLSA study team, Thomas Gregor Issac, SANSCOG study team, Jonas Sundarakumar, Bratati Kahali   +10 more
wiley   +1 more source

Identification of Differentially Expressed Genes after Endurance Runs in Karbadian Horses to Determine Candidates for Stress Indicators and Performance Capability

, 2023
RNA sequencing makes it possible to uncover genetic mechanisms that underlie certain performance traits. In order to gain a deeper insight into the genetic background and biological processes involved in endurance performance in horses, the changes in ...
Reißmann, Monika, Armin O. Schmitt, Schmitt, Armin O., Kokov, Zaur A., Zaur A. Kokov, Abirami Rajavel, Rajavel, Abirami, Monika Reißmann   +7 more
core   +1 more source

Gaudichaudione H Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Disulfidptosis via Regulating NRF2‐SLC7A11 Signaling Pathway

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Gaudichaudione H (GH) effectively activates NRF2 signaling and its target genes, such as SLC7A11, and pharmaceutical activation of NRF2‐SLC7A11 signaling pathway aggravates uptake of cysteine, disturbance of GSH synthesis, depletion of NADPH, and accumulation of disulfide molecules, ultimately leading to the formation of disulfide bonds between ...
Mengjiao Shi, Xinyan Li, Ying Guo, Yinggang Zhang, Jiayi Xu, Liangwen Yan, Rongrong Liu, Hong Wang, Shenkang Tang, Yaping Zhao, Zongfang Li, Yetong Feng, Dongmei Ren, Pengfei Liu   +13 more
wiley   +1 more source