Results 61 to 70 of about 1,264 (145)

Transcriptome Analysis of Bovine Ovarian Follicles at Predeviation and Onset of Deviation Stages of a Follicular Wave

International Journal of Genomics, Volume 2016, Issue 1, 2016., 2016
For two libraries (PDF1 and ODF1) using Illumina sequencing 44,082,301 and 43,708,132 clean reads were obtained, respectively. After being mapped to the bovine RefSeq database, 15,533 genes were identified to be expressed in both types of follicles (cut‐off RPKM > 0.5), of which 719 were highly expressed in bovine follicles (cut‐off RPKM > 100 ...
Pengfei Li, Jinzhu Meng, Wenzhong Liu, George W. Smith, Jianbo Yao, Lihua Lyu, Ferenc Olasz   +6 more
wiley   +1 more source

Autophagy in Lysosomal Storage Disorders [PDF]

, 2012
Lysosomes are ubiquitous intracellular organelles that have an acidic internal pH, and play crucial roles in cellular clearance. Numerous functions depend on normal lysosomes, including the turnover of cellular constituents, cholesterol homeostasis ...
Ballabio, Andrea, Lieberman, Andrew P., Puertollano, Rosa, Raben, Nina, Slaugenhaupt, Susan Ann, Walkley, Steven U.   +5 more
core   +1 more source

Genome‐wide study links cardiometabolic factors to cognition via APOA4‐APOA5‐ZPR1‐BUD13 and other loci in rural Indians

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION Cardiometabolic risks affect cognition during aging, yet genetic basis for both remain understudied in Indians. METHODS This study constructs an ancestry‐matched Indian haplotype reference panel for genotype imputation of 5111 rural Indians. Single‐locus, gene‐based, conditional genome‐wide association analyses are performed on 20
Shreya Chakraborty, Krithika Subramanian, Akkshaya Rajesh, Rupanwita Majumder, Khader Valli Rupanagudi, Abhishek Mensegere, TLSA study team, Thomas Gregor Issac, SANSCOG study team, Jonas Sundarakumar, Bratati Kahali   +10 more
wiley   +1 more source

Autophagy in Drosophila: From Historical Studies to Current Knowledge

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly revolutionized this research field and made it possible to carry out functional studies on model organisms. Insects including Drosophila are classical and still popular models to study autophagy, starting from the 1960s.
Nitha C. Mulakkal, Peter Nagy, Szabolcs Takats, Radu Tusco, Gábor Juhász, Ioannis P. Nezis, Rodney J. Devenish   +6 more
wiley   +1 more source

Genome-wide association study of serum magnesium in type 2 diabetes. [PDF]

Genes Nutr
People with type 2 diabetes have a tenfold higher prevalence of hypomagnesemia, which is suggested to be caused by low dietary magnesium intake, medication use, and genetics.
Oost LJ, Slieker RC, Blom MT, 't Hart LM, Hoenderop JGJ, Beulens JWJ, de Baaij JHF.   +6 more
europepmc   +3 more sources

Protective role of the Atg8 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease

bioRxiv, 2021
Diabetic heart disease is highly prevalent and characterized by diastolic dysfunction. The mechanisms of diabetic heart disease are poorly understood and no targeted therapies are available.
K. Mellor, U. Varma, P. Koutsifeli, C. Curl, J. Janssens, L. Daniels, G. Bernasochi, A. Raaijmakers, V. Benson, E. Chan, M. Annandale, Xun Li, Y. Nursalim, Wendy T. K. Ip, David J. R. Taylor, K. Raedschelders, A. Stotland, Aaron E. Robinson, R. Mills, R. Lamberts, Kim L Powell, Terence J. O’Brien, R. Katare, C. Chandramouli, R. Ritchie, Shiang Y. Lim, R. Parton, Xinli Hu, J. Bell, E. Porrello, James E. Hudson, Rui-Ping Xiao, J. V. Van Eyk, R. Gottlieb, L. Delbridge   +34 more
semanticscholar   +1 more source

Coexpression within Integrated Mitochondrial Pathways Reveals Different Networks in Normal and Chemically Treated Transcriptomes

International Journal of Genomics, Volume 2014, Issue 1, 2014., 2014
As energy producers, mitochondria play a pivotal role in multiple cellular processes. Although several lines of evidence suggest that differential expression of mitochondrial respiratory complexes (MRCs) has a significant impact on mitochondrial function, the role of integrated MRCs in the whole coexpression network has yet to be revealed.
Cong Chen, Tae Kyung Hyun, Xiao Han, Zhihui Feng, Yuan Li, Xiaolong Liu, Jiankang Liu, Graziano Pesole   +7 more
wiley   +1 more source

Integrative bulk and single-cell transcriptome analyses reveal RNA modification–related biomarkers of spinal cord injury

Neural Regeneration Research
Aberrant RNA modification has been linked to the pathogenesis of various diseases; however, its specific molecular mechanisms in spinal cord injury remain poorly understood.
Shixue Huang, Kun Jiao, Keqing Li, Jiayan Yuan, Haoming Shu, Yinuo Zhang, Xin Zhou, Xuhui Zhou   +7 more
doaj   +1 more source

Gaudichaudione H Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Disulfidptosis via Regulating NRF2‐SLC7A11 Signaling Pathway

Advanced Science, Volume 12, Issue 11, March 20, 2025.
Gaudichaudione H (GH) effectively activates NRF2 signaling and its target genes, such as SLC7A11, and pharmaceutical activation of NRF2‐SLC7A11 signaling pathway aggravates uptake of cysteine, disturbance of GSH synthesis, depletion of NADPH, and accumulation of disulfide molecules, ultimately leading to the formation of disulfide bonds between ...
Mengjiao Shi, Xinyan Li, Ying Guo, Yinggang Zhang, Jiayi Xu, Liangwen Yan, Rongrong Liu, Hong Wang, Shenkang Tang, Yaping Zhao, Zongfang Li, Yetong Feng, Dongmei Ren, Pengfei Liu   +13 more
wiley   +1 more source

Glucose‐mediated mitochondrial reprogramming by cholesterol export at TM4SF5‐enriched mitochondria‐lysosome contact sites

Cancer Communications, Volume 44, Issue 1, Page 47-75, January 2024.
Abstract Background Transmembrane 4 L six family member 5 (TM4SF5) translocates subcellularly and functions metabolically, although it is unclear how intracellular TM4SF5 translocation is linked to metabolic contexts. It is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory
Ji Eon Kim, So‐Young Park, Chulhwan Kwak, Yoonji Lee, Dae‐Geun Song, Jae Woo Jung, Haesong Lee, Eun‐Ae Shin, Yangie Pinanga, Kyung‐hee Pyo, Eun Hae Lee, Wonsik Kim, Soyeon Kim, Chang‐Duck Jun, Jeanho Yun, Sun Choi, Hyun‐Woo Rhee, Kwang‐Hyeon Liu, Jung Weon Lee   +18 more
wiley   +1 more source