Results 31 to 40 of about 854 (122)

A gene network of uterine luminal epithelium organizes mouse blastocyst implantation

Reproductive Medicine and Biology, Volume 21, Issue 1, January/December 2022., 2022
Abstract Purpose The receptive endometrium is critical for blastocyst implantation. In mice, after blastocysts enter the uterine cavities on day 4 of pregnancy (day 1 = vaginal plug), blastocyst attachment is completed within 24 h, accompanied by dynamic interactions between the uterine luminal epithelium and the blastocysts.
Shizu Aikawa, Yasushi Hirota, Yamato Fukui, Chihiro Ishizawa, Rei IIda, Tetsuaki Kaku, Tomoyuki Hirata, Shun Akaeda, Takehiro Hiraoka, Mitsunori Matsuo, Yutaka Osuga   +10 more
wiley   +1 more source

A guide to the regulation of selective autophagy receptors

The FEBS Journal, Volume 289, Issue 1, Page 75-89, January 2022., 2022
Selective autophagy receptors are essential for bridging the cellular cargo destined for degradation with autophagy machinery. As such, their role in autophagy is strictly regulated. In this review, we outline and discuss post‐translational (phosphorylation, ubiquitination, acetylation) and structural (oligomerisation) modifications involved in ...
Andrea Gubas, Ivan Dikic
wiley   +1 more source

Gene Signatures for Latent Radiation-Induced Lung Injury Post X-ray Exposure in Mouse

Dose-Response, 2023
Objective To investigate the X-ray-specific sensitive genes and potential signaling pathways involved in the latent period of radiation-induced lung injury (RILI) in mouse models.
Tongtong Zhang, Zhaoming Zhou, Lei Wen, Changguo Shan, Mingyao Lai, Jing Liao, Xin Zeng, Gang Yan, Linbo Cai, Meijuan Zhou, Minghua Wang   +10 more
doaj   +1 more source

Bioinformatics Analysis Identifies TNFRSF1A as a Biomarker of Liver Injury in Sepsis TNFRSF1A is a Biomarker for Septic Liver Injury

Genetics Research , Volume 2022, Issue 1, 2022., 2022
Sepsis is a severe disease with high mortality, and liver injury is an independent risk factor for sepsis morbidity and mortality. We analyzed co‐differentially expressed genes (co‐DEGs) to explore potential biomarkers and therapeutic targets for sepsis‐related liver injury.
Shangxun Zhou, Wei Zhao, Junjie Li, Yang Huang, Jing Yang, Qianmei Wang, Yunyun Xu, Chujun Duan, Yutong Wang, Wen Yin, Qiuhong Xiong   +10 more
wiley   +1 more source

Modeling Phenotypic Heterogeneity of Glycogen Storage Disease Type 1a Liver Disease in Mice by Somatic CRISPR/CRISPR‐associated protein 9–Mediated Gene Editing

Hepatology, Volume 74, Issue 5, Page 2491-2507, November 2021., 2021
Background and Aims Patients with glycogen storage disease type 1a (GSD‐1a) primarily present with life‐threatening hypoglycemia and display severe liver disease characterized by hepatomegaly. Despite strict dietary management, long‐term complications still occur, such as liver tumor development.
Martijn G.S. Rutten, Terry G.J. Derks, Nicolette C.A. Huijkman, Trijnie Bos, Niels J. Kloosterhuis, Kees C.W.A. van de Kolk, Justina C. Wolters, Mirjam H. Koster, Laura Bongiovanni, Rachel E. Thomas, Alain de Bruin, Bart van de Sluis, Maaike H. Oosterveer   +12 more
wiley   +1 more source

Construction of a ceRNA coregulatory network and screening of hub biomarkers for salt‐sensitive hypertension

Journal of Cellular and Molecular Medicine, Volume 24, Issue 13, Page 7254-7265, July 2020., 2020
Abstract Salt‐sensitive hypertension (SSH) is an independent risk factor for cardiovascular disease. The regulation of long non‐coding RNAs, mRNAs and competing endogenous RNAs (ceRNAs) in the pathogenesis of SSH is uncertain. An RNA microarray was performed to discover SSH‐associated differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs ...
Ling Zhang, Han Qi, Zheng Liu, Wen‐Juan Peng, Han Cao, Chun‐Yue Guo, Yan‐Yan Sun, Christine Pao, Yu‐Tao Xiang   +8 more
wiley   +1 more source

Identification of Potential Key Genes and Pathways in Enzalutamide‐Resistant Prostate Cancer Cell Lines: A Bioinformatics Analysis with Data from the Gene Expression Omnibus (GEO) Database

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Enzalutamide (ENZ) has been approved for the treatment of advanced prostate cancer (PCa), but some patients develop ENZ resistance initially or after long‐term administration. Although a few key genes have been discovered by previous efforts, the complete mechanisms of ENZ resistance remain unsolved.
Long Zheng, Xiaojie Dou, Xiaodong Ma, Wei Qu, Xiaoshuang Tang, Sivagnanam Thamilselvan   +5 more
wiley   +1 more source

Model-based analysis uncovers mutations altering autophagy selectivity in human cancer [PDF]

, 2021
Autophagy can selectively target protein aggregates, pathogens, and dysfunctional organelles for the lysosomal degradation. Aberrant regulation of autophagy promotes tumorigenesis, while it is far less clear whether and how tumor-specific alterations ...
守田, 剛, 40804513, Morita, Tsuyoshi, 馬場, 麻人, Zhang, Weizhi, モリタ, ツヨシ, Shen, Xiaofei, Liu, Xiaohui, ババ, オト, Deng, Wankun, 304903/profile-ja.html, 871, Ning, Wanshan, Shang, Zehua, Jia, Da, Xue, Yu, Baba, Otto, 323772/profile-ja.html, 812, Chen, Lu, Wang, Chenwei, Han, Zhu, 90251545, Li, Zhidan   +23 more
core  

The selectivity and specificity of autophagy in drosophila [PDF]

, 2012
Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a ...
Nezis, I. P., Ioannis P. Nezis
core   +1 more source

A role of glycerophosphodiesterase EDI3 in glycogen metabolism [PDF]

, 2020
The glycerophosphodiesterase EDI3 (endometrial differential 3) is a key enzyme in various metabolic signalling pathways because it cross-links the triglyceride and choline signalling pathway by hydrolysing glycerophosphocholine (GPC) to glycerol-3 ...
Leonhardt, Gregor M.
core   +1 more source