BIOCHEMICAL APPROACHES FOR THE DIAGNOSIS AND TREATMENT OF LAFORA DISEASE [PDF]
, 2019 Glycogen is the sole carbohydrate storage molecule found in mammalian cells and plays an important role in cellular metabolism in nearly all tissues, including the brain.
Brewer, Mary Kathryn
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Molecular MetabolismObjective: Carbohydrate Response Element Binding Protein (ChREBP) is a glucose 6-phosphate (G6P)-sensitive transcription factor that acts as a metabolic switch to maintain intracellular glucose and phosphate homeostasis.
K.A. Krishnamurthy +13 more
doaj +1 more source
Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet [PDF]
, 2019 Annexin A6 (AnxA6) controls cholesterol and membrane transport in endo- and exocytosis,and modulates triglyceride accumulation and storage. In addition, AnxA6 acts as a scaffolding protein for negative regulators of growth factor receptors and their ...
Alvarez Guaita, Anna +11 more
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Exploring therapeutic targets for glycogen storage disease type 1 by modulating signal transduction pathways in hepatic in vivo and ex vivo models [PDF]
This PhD thesis investigates the regulation of glucose 6-phosphatase (G6PC)-independent glucose production in hepatic Glycogen Storage Disease (GSD) types Ia and Ib, aiming to optimize glucose homeostasis and reduce hepatic glycogen accumulation ...
Alagere Krishnamurthy, Kishore
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Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice [PDF]
, 2017 Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and ...
Casarini, Dulce E. +9 more
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The Role of Mitochondrial Genetic Background in Cellular Function, Response to Cell Stress and Disease Susceptability [PDF]
, 2022 There is a differential susceptibility associated with several diseases including cardiovascular disease (CVD) and hypertension, with Blacks being more likely to develop these conditions. Blacks are also more likely to die from these diseases. To explain
Brown, Jamelle A
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A role of glycerophosphodiesterase EDI3 in glycogen metabolism [PDF]
, 2020 The glycerophosphodiesterase EDI3 (endometrial differential 3) is a key enzyme in various metabolic signalling pathways because it cross-links the triglyceride and choline signalling pathway by hydrolysing glycerophosphocholine (GPC) to glycerol-3 ...
Leonhardt, Gregor M.
core
Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease [PDF]
, 2014 The prevalence of overweight and obese individuals has been recognized globally for decades. Of all countries, United States has the highest rate of obesity. One third of its adult population is obese, and around two thirds are overweight.
Fu, Ting
core
Nature Cardiovascular ResearchABSTRACT Diabetic heart disease is highly prevalent and is associated with the early development of impaired diastolic relaxation. The mechanisms of diabetic heart disease are poorly understood and it is a condition for which there are no targeted therapies.
K. M. Mellor +25 more
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Autophagy, a Highly Regulated Intracellular System Essential to Skeletal Muscle Homeostasis — Role in Disease, Exercise and Altitude Exposure [PDF]
, 2015 Autophagy is an evolutionarily conserved intracellular system that selectively eliminates protein aggregates, damaged organelles, and other cellular debris.
Bernardi, Henri +3 more
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