Results 61 to 70 of about 576 (126)

Immune modulation through secretory autophagy

Journal of Cellular Biochemistry, Volume 125, Issue 11, November 2024.
Abstract Autophagy is a central mechanism of cellular homeostasis through the degradation of a wide range of cellular constituents. However, recent evidence suggests that autophagy actively provides information to neighboring cells via a process called secretory autophagy. Secretory autophagy couples the autophagy machinery to the secretion of cellular
Andreas Weigert, Lina Herhaus
wiley   +1 more source

Impaired mitophagy in Sanfilippo A mice causes hypertriglyceridemia and brown adipose tissue activation [PDF]

, 2022
Lysosomal storage diseases result in various developmental and physiological complications, including cachexia. To study the causes for the negative energy balance associated with cachexia, we assessed the impact of sulfamidase deficiency and heparan ...
Dickson, Patricia I, et al.,, Tillo, Miguel   +2 more
core   +2 more sources

Advances in natural products modulating autophagy influenced by cellular stress conditions and their anticancer roles in the treatment of ovarian cancer

The FASEB Journal, Volume 38, Issue 19, 15 October 2024.
Natural products can influence various intracellular stress responses, thereby controlling the malignant biological behavior of ovarian cancer and affecting its progression. Abstract Autophagy is a conservative catabolic process that typically serves a cell‐protective function.
Dongxiao Li, Danbo Geng, Min Wang
wiley   +1 more source

Adipose tissue glycogen accumulation is associated with obesity-linked inflammation in humans [PDF]

, 2021
Objective: glycogen metabolism has emerged as a mediator in the control of energy homeostasis and studies in murine models reveal that adipose tissue might contain glycogen stores.
Ceperuelo-Mallafré, Victoria, Duran, Xevi, Ejarque, Miriam, Fernández-Veledo, Sonia, García-Roves, Pablo, Garrido-Sanchez, Lourdes, Gómez Foix, Anna Maria, Montori Grau, Marta, Núñez-Roa, Catalina, Puthanveetil, Prasanth, Roche, Kelly, Rodríguez, Miguel Angel, Saez, Enrique, Saltiel, Alan R., Serena, Carolina, Tinahones, Francisco J., Vendrell, Joan, Yanes, Oscar   +17 more
core   +1 more source

The glycogenolytic enzyme acid α‐glucosidase is expressed in the bovine uterine endometrium

Reproduction in Domestic Animals, Volume 59, Issue 6, June 2024.
Abstract Progesterone has been shown to stimulate glycogen catabolism in uterine epithelial cells. Acid α‐glucosidase (GAA) is an enzyme that breaks down glycogen within lysosomes. We hypothesized that progesterone may stimulate glycogenolysis in the uterine epithelium via GAA.
Malia D. Berg, Matthew Dean
wiley   +1 more source

Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation [PDF]

, 2022
Channelling of glucose via glycogen, known as the glycogen shunt, may play an important role in the metabolism of brain tumours, especially in hypoxic conditions.
304903/profile-ja.html, 812, 90251545, Baba, Otto, Bridges, Esther, Buffa, Francesca M., Dunnen, Wilfred F. A.den, Fehrmann, Rudolf S.N., Haider, Syed, Harris, Adrian L., Hendriks, Anne M., Jalving, Mathilde, Kalamida, Dimitra, Lagerholm, B. Christoffer, McCullagh, James S. O., Morris, John, Pires, Elisabete, Tarasov, Andrei I., Voukantsis, Dimitrios, Zois, Christos E., ババ, オト, 馬場, 麻人   +21 more
core  

Regulation of proteasome assembly and activity in health and disease [PDF]

, 2018
The proteasome degrades most cellular proteins in a controlled and tightly regulated manner and thereby controls many processes, including cell cycle, transcription, signalling, trafficking and protein quality control. Proteasomal degradation is vital in
A Ciechanover, A González, A Hanssum, A Hershko, A Kelly, A Kniepert, A Lehmann, A Lupas, A Mota-Peynado De La, A Navon, A Padmanabhan, A Parmigiani, A Reinke, A Roczniak-Ferguson, A Rousseau, A Schweitzer, A Suraweera, A Varshavsky, Adrien Rousseau, AG Marshall, AL Goldberg, AM Ripen, Anne Bertolotti, AR Kusmierczyk, AR Kusmierczyk, AV Gomes, B Li, B Tallec Le, B Tallec Le, B-H Lee, BI Florea, BM Stadtmueller, BM Stadtmueller, C López-Otín, C Settembre, C-W Liu, CM Dambacher, CS Arendt, D Acosta-Alvear, D Finley, D Komander, D Nandi, D Vilchez, D Vilchez, D Vilchez, D Walerych, D-H Kim, D-H Kim, DC Kraft, DM Smith, E Estrin, E Haar Vander, E Im, E Pick, E Pilla, E Witt, EE Manasanch, EM Huber, F Förster, F Li, FE Langlands, FH Schopf, G Asher, G Ben-Nissan, G Kaur, G Mannhaupt, GA Collins, GC Lander, GP Sykiotis, H Higashitsuji, H Hisamatsu, H Kimura, H Nakatogawa, H Uechi, H Yu, HM Nguyen, I Dikic, I Livneh, I Saez, J Hamazaki, J Hamazaki, J Hashimoto, J Imai, J Kaur, J Kikuchi, J Kim, J Onodera, J Roelofs, J Zhao, J Zhao, J-RQ Acquah, J-T Lin, JA Martina, JL Hopper, K Fukunaga, K Hara, K Parzych, K Satoh, K Taguchi, K Tanaka, K Tanaka, KA Waite, L Bedford, L Budenholzer, L Chantranupong, L Chantranupong, L Wang, L Wrobel, M Asai, M Bajorek, M Freeman, M Funakoshi, M Groettrup, M Groll, M Izumikawa, M Kock, M Ma, M Unno, M Zettl, M-B Barrault, M-K Kwak, M-K Kwak, M-X Qian, MA Hoyt, Marion Schmidt, ME Pereira, MF Kleijnen, MH Glickman, MJ Kunjappu, N Bergbold, N Chondrogianni, N Chondrogianni., N Livnat-Levanon, N Myeku, N Myeku, NJ Lehrbach, NP Gladman, O Coux, P Cascio, P Šledž, PC Ramos, PCA Fonseca da, PF Cho-Park, PS Wani, R Glynne, R Loewith, R Shirozu, RA Saxton, RA Saxton, RJ Tomko, RJ Tomko, RJ Tomko, RJ Tomko Jr., RJ Tomko Jr., RM Vabulas, RS Marshall, RS Marshall, S Bhattacharyya, S Dawson, S Heink, S Kapeta, S Kaushik, S Koizumi, S Lokireddy, S Meiners, S Murata, S Murata, S Nocker van, S Park, S Park, S Park, S Park, S Prakash, S Sun, S Varambally, SAH Poot de, SK Eskandari, SK Radhakrishnan, SY-C Lee, T Akahane, T Finkel, T Fujiwara, T Inobe, T Kaneko, T Luo, T Satoh, T Yamano, TA Griffin, TA Grigoreva, U Tomaru, V Cohen-Kaplan, V Ortiz-Navarrete, V Sokolova, VR Young, W Lee, X Gao, X Guo, X Guo, X Huang, X Li, X Li, X Li, X Wang, X Wang, X Zhang, Y Hirano, Y Hirano, Y Hirano, Y Ohsumi, Y Saeki, Y Saeki, Y Sancak, Y Shi, Y Xie, Y Yabuta, Y Zhang, Z Sha   +216 more
core   +2 more sources

Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles. [PDF]

The naked mole-rat Heterocephalus glaber is a eusocial mammal exhibiting extreme longevity (37-year lifespan), extraordinary resistance to hypoxia and absence of cardiovascular disease.
Aksentijevic, D, Bennett, NC, Charles, RL, Eykyn, TR, Faulkes, CG, Gilbert, JD, Hart, DW, Miljkovic, JL, Murphy, MP, Patel, N, Prag, HA   +10 more
core   +1 more source

Defective liver glycogen autophagy related to hyperinsulinemia in intrauterine growth-restricted newborn wistar rats [PDF]

, 2020
Maternal malnutrition plays a critical role in the developmental programming of later metabolic diseases susceptibility in the offspring, such as obesity and type 2 diabetes.
de Toro-Martín, Juan, Escrivá, Fernando, Fernández-Marcelo, Tamara, Fernández-Millán, Elisa, González-Rodríguez, Águeda, Valverde, Ángela M., Álvarez, Carmen   +6 more
core   +1 more source

STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma

Cell Reports
Summary: The accumulation of lipid droplets (LDs) and glycogen is a major hallmark of clear cell renal cell carcinoma (ccRCC), yet their interplay remains unclear.
Hao Wang, Tong Xiao, Hao Zhuang, Yi Liu, Kexing Jin, Jing Li, Jun Li, Yan Gao, Dan Yue, Wei Cui, Qingxia Xu, Jingxuan Pan, Kangdong Liu, Yong Wang, Ruibing Chen, Hongle Li   +15 more
doaj   +1 more source