Results 91 to 100 of about 473 (103)

Cardiomyocyte glycophagy is regulated by insulin and exposure to high extracellular glucose

American Journal of Physiology - Heart and Circulatory Physiology, 2014
Disturbed systemic glycemic and insulinemic status elicits cardiomyocyte metabolic stress and altered glucose handling. In diabetes, pathological myocardial glycogen accumulation occurs. Recently, evidence of a specific myocardial autophagic degradation pathway for glycogen (“glycophagy”) has been reported, differentiated from the more well ...
Kimberley M Mellor, Upasna Varma, Lea M D Delbridge   +2 more
exaly   +4 more sources

D‐pinitol alleviates diabetic cardiomyopathy by inhibiting the optineurin‐mediated endoplasmic reticulum stress and glycophagy signaling pathway

Phytotherapy Research
AbstractDiabetic cardiomyopathy (DCM) is an important complication resulting in heart failure and death of diabetic patients. However, there is no effective drug for treatments. This study investigated the effect of D‐pinitol (DP) on cardiac injury using diabetic mice and glycosylation injury of cardiomyocytes and its molecular mechanisms.
Wenqian Zhao, Chaochao Dai, Mei Cheng
exaly   +4 more sources

Glycophagy: A selective autophagy pathway for glycogen degradation

International Review of Cell and Molecular Biology
Pascual Sanz, Maria Adelaida Garcia-Gimeno   +1 more
exaly   +3 more sources

Glycophagy is an Effective Therapeutic Target to Remediate Diastolic Dysfunction in Diabetic Heart Disease

Heart, Lung and Circulation
Mellor, K., Koutsifeli, P., Varma, U., Curl, C., Janssens, J., Raaijmakers, A., Mills, R., Hudson, J., Porrello, E., Bell, J., Weeks, K., Delbridge, L.   +11 more
openaire   +3 more sources

Endoplasmic reticulum stress-mediated glycophagy drives macrophage M1 polarization in silica nanoparticles-induced pulmonary fibrosis

Journal of Environmental Sciences
Lei Bao, Zihan Geng, Linpeng Niu, Lili Shi, Liyi He, Yaxian Pang, Cunhui Zhang, Yan Liu, Jiawei Chen, Beibei Shi, Ruiting Wu, Jingyuan Wang, Yujie Niu, Rong Zhang   +13 more
openaire   +2 more sources

Glycogen Responses During Metabolic Stress are Accentuated in Female Hearts: A Role for Myocardial Glycophagy

Heart, Lung and Circulation, 2013
M. Reichelt, K. Mellor, D. Stapleton, L. Delbridge   +3 more
openaire   +2 more sources

sj-pdf-1-jcb-10.1177_0271678X211027384 - Supplemental material for Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity

2021
Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211027384 for Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity by Eleonora Napoli, Alexios A Panoutsopoulos, Patricia Kysar, Nathaniel Satriya, Kira Sterling, Bradley Shibata, Denise Imai, David N Ruskin, Konstantinos S Zarbalis and Cecilia Giulivi in Journal of Cerebral Blood Flow &
Napoli, Eleonora, Panoutsopoulos, Alexios A, Kysar, Patricia, Satriya, Nathaniel, Sterling, Kira, Shibata, Bradley, Imai, Denise, Ruskin, David N, Zarbalis, Konstantinos S, Giulivi, Cecilia   +9 more
openaire   +1 more source

Acid α-Glucosidase Impairs Diabetic Bone Regeneration via Altering Macrophage Polarization

Journal of dentistry research
The diabetic microenvironment intensifies M1-type macrophage–mediated inflammation and impairs bone regeneration. Glycophagy—a process of glycogen-selective autophagy that degrades intracellular glycogen into glucose—is essential for maintaining glucose ...
S.C. Yu, J.F. Liang, Y. Li, S. Ma, J. Sun, A. Li, D. Pei   +6 more
semanticscholar   +1 more source

Autophagy in Skeletal Muscle.

Cold Spring Harbor Perspectives in Biology
Skeletal muscle fibers possess, like all cells of our body, an evolutionary conserved autophagy machinery, which allows them to segregate unfolded proteins and damaged organelles within autophagosomes, and to induce fusion of autophagosomes with ...
Anais Franco-Romero, Marco Sandri, Stefano Schiaffino   +2 more
semanticscholar   +1 more source

Defect in degradation of glycogenin‐exposed residual glycogen in lysosomes is the fundamental pathomechanism of Pompe disease

Journal of Pathology
Pompe disease is a lysosomal storage disorder that preferentially affects muscles, and it is caused by GAA mutation coding acid alpha‐glucosidase in lysosome and glycophagy deficiency. While the initial pathology of Pompe disease is glycogen accumulation
Na Zhang, Fuchen Liu, Yuying Zhao, Xiaohan Sun, Bing Wen, Jian-Qiang Lu, C. Yan, Duoling Li   +7 more
semanticscholar   +1 more source