Results 31 to 40 of about 401 (96)

A chromosome‐level genome of Antechinus flavipes provides a reference for an Australian marsupial genus with male death after mating

Molecular Ecology Resources, Volume 22, Issue 2, Page 740-754, February 2022., 2022
Abstract The 15 species of small carnivorous marsupials that comprise the genus Antechinus exhibit semelparity, a rare life‐history strategy in mammals where synchronized death occurs after one breeding season. Antechinus males, but not females, age rapidly (demonstrate organismal senescence) during the breeding season and show promise as new animal ...
Ran Tian, Kai Han, Yuepan Geng, Chen Yang, Chengcheng Shi, Patrick B. Thomas, Coral Pearce, Kate Moffatt, Siming Ma, Shixia Xu, Guang Yang, Xuming Zhou, Vadim N. Gladyshev, Xin Liu, Diana O. Fisher, Lisa K. Chopin, Natália O. Leiner, Andrew M. Baker, Guangyi Fan, Inge Seim   +19 more
wiley   +1 more source

Regulation and role of glycophagy in skeletal muscle energy metabolism

, 2021
Glycophagy is the autophagic degradation of glycogen via the lysosomal enzyme GAA/alpha-acid glucosidase. Glycophagy is considered a housekeeping process to degrade poorly branched glycogen particles, but the regulation and role of glycophagy in skeletal
Timothy D. Heden (3710056), Curtis C. Hughey (3686770), Lisa S. Chow (5597075), Douglas G. Mashek (8467239)   +3 more
core   +1 more source

A guide to the regulation of selective autophagy receptors

The FEBS Journal, Volume 289, Issue 1, Page 75-89, January 2022., 2022
Selective autophagy receptors are essential for bridging the cellular cargo destined for degradation with autophagy machinery. As such, their role in autophagy is strictly regulated. In this review, we outline and discuss post‐translational (phosphorylation, ubiquitination, acetylation) and structural (oligomerisation) modifications involved in ...
Andrea Gubas, Ivan Dikic
wiley   +1 more source

Selective autophagy

Cancer Science, Volume 112, Issue 10, Page 3972-3978, October 2021., 2021
In this short review, we focus on the mechanism of "selective" autophagy, which is rapidly being elucidated. Abstract While starvation‐induced autophagy is thought to randomly degrade cellular components, under certain circumstances autophagy selectively recognizes, sequesters, and degrades specific targets via autophagosomes.
Mohammad Omar Faruk, Yoshinobu Ichimura, Masaaki Komatsu   +2 more
wiley   +1 more source

A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Lipids are integral cellular components that act as substrates for energy provision, signaling molecules, and essential constituents of biological membranes along with a variety of other biological functions. Despite their significance, lipid accumulation may result in lipotoxicity, impair autophagy, and lysosomal function that may lead to certain ...
Muhammad Babar Khawar, Muddasir Hassan Abbasi, Mussarat Rafiq, Naila Naz, Rabia Mehmood, Nadeem Sheikh, Carla Tatone   +6 more
wiley   +1 more source

Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act

Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated primarily from endogenous biochemical reactions in mitochondria, endoplasmic reticulum (ER), and peroxisomes. Typically, ROS/RNS correlate with oxidative damage and cell death; however, free radicals are also crucial for normal cellular functions, including supporting ...
Natalia Jimenez-Moreno, Jon D. Lane, Claudio De Lucia   +2 more
wiley   +1 more source

New Toolset of Reporters Reveals That Glycogen Granules Are Neutral Substrates of Bulk Autophagy in <i>Komagataella phaffii</i>. [PDF]

Int J Mol Sci
Glycogen, a branched polysaccharide organized into glycogen granules (GGs), is delivered from the cytoplasm to the lysosomes of hepatocytes by STBD1-driven selective autophagy (glycophagy).
Wijewantha NV, Battu P, Chen K, Kumar R, Nazarko TY.   +4 more
europepmc   +2 more sources

Nutritional Intervention of Zinc on Metabolic Disorders Induced by High‐Starch Diets in Largemouth Bass (Micropterus salmoides): Insights From Glycogen Metabolism and Insulin Sensitivity

Aquaculture Nutrition, Volume 2026, Issue 1, 2026.
Metabolic disorders induced by high‐starch diets are the primary cause limiting the use of carbohydrates in aquafeeds. This study aimed to investigate the intervention effects of zinc on metabolic disorders induced by high‐starch diets in Micropterus salmoides.
Bo Shi, Xiaoxuan Yu, Ziyu Yin, Bo Wang, Jiaming Kang, Baoping Zhang, Zhiyong Dong, Xiaofang Liang, Wanjie Cai, Yuexing Zhang, Antony Jesu Prabhu Philip   +10 more
wiley   +1 more source

Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 6, Issue 9, September 2025.
Astrocytes display heterogeneity in various neurological disorders and behavioral neuropsychiatric disorders. Astrocytes influence the progression of neurological diseases through neuroinflammation, oxidative stress, metabolic abnormalities, intercellular interactions, and a spectrum of other pathophysiological processes.
Shijie Mao, Rui Qiao, Qi Wang, Ling Shen, Daxing Li, Xinchen Huo, Jindou Wang, Kunxuan Liu, Wenjing Chen, Tianhao Zhu, Beicheng Zhang, Shuo Leng, Ying Bai   +12 more
wiley   +1 more source

HEPATIC GLUCOSE PRODUCTION BY GLYCOPHAGY IS CONTROLLED BY THE SMALL GTPASE RAB4B

International audienceBackground: Endocytic trafficking, controlled by small GTPases of the Rab family, regulates the intracellular transport of metabolic signaling receptors and nutrients, either for degradation via late endosomes and lysosomes, or back
Cormont, Mireille, Sabbane, Sihame, Leparc, Lucie, Zeigerer, Anja, Marion, Dussot, Chafik, Abderrahman, Gilleron, Jérôme, Tanti, Jean-Francois   +7 more
core   +4 more sources