Results 31 to 40 of about 576 (126)

Myocardial glycophagy flux dysregulation and glycogen accumulation characterize diabetic cardiomyopathy

Journal of Molecular and Cellular Cardiology
Diabetic heart disease morbidity and mortality is escalating. No specific therapeutics exist and mechanistic understanding of diabetic cardiomyopathy etiology is lacking. While lipid accumulation is a recognized cardiomyocyte phenotype of diabetes, less is known about glycolytic fuel handling and storage.
Parisa Koutsifeli, Kate L Weeks, Rajesh G Katare   +2 more
exaly   +4 more sources

Osteocalcin modulates hippocampal activities and influences glycophagy within astrocytes in a chronic unpredictable mild stress mouse model. [PDF]

Compr Psychoneuroendocrinol
Chen H, Mao J, Wang M, Zhang Q, Zheng R, Wu Y, Ma X, Liu Q.   +7 more
europepmc   +3 more sources

Increased Expression of Autophagy-Related Genes in Alzheimer’s Disease—Type 2 Diabetes Mellitus Comorbidity Models in Cells [PDF]

, 2023
The association between Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) has been extensively demonstrated, but despite this, the pathophysiological mechanisms underlying it are still unknown.
Anni D., Boriero D., Buffelli M., Carboni L., Salluzzo M., Vianello C.   +5 more
core   +4 more sources

A putative adverse outcome network for neonatal mortality and lower birth weight in rodents: Applicability to per‐ and polyfluoroalkyl substances and relevance to human health

Birth Defects Research, Volume 115, Issue 11, Page 1011-1062, June 15, 2023., 2023
Abstract Background Some per‐ and poly‐fluoroalkyl substances (PFAS) cause neonatal mortality and lower birth weight in rodents. We constructed an Adverse Outcome Pathway (AOP) network for neonatal mortality and lower birth weight in rodents, comprising three putative AOPs.
John M. Rogers, Melissa M. Heintz, Chad M. Thompson, Laurie C. Haws   +3 more
wiley   +1 more source

Decoding the molecular mechanism of selective autophagy of glycogen mediated by autophagy receptor STBD1 [PDF]

Proceedings of the National Academy of Sciences of the United States of America
yuchao zhang, Yingli Wang, Jianping Liu
exaly   +2 more sources

Lysosomal glycogen accumulation in Pompe disease results in disturbed cytoplasmic glycogen metabolism

Journal of Inherited Metabolic Disease, Volume 46, Issue 1, Page 101-115, January 2023., 2023
Abstract Pompe disease is an inherited metabolic myopathy caused by deficiency of acid alpha‐glucosidase (GAA), resulting in lysosomal glycogen accumulation. Residual GAA enzyme activity affects disease onset and severity, although other factors, including dysregulation of cytoplasmic glycogen metabolism, are suspected to modulate the disease course ...
Rodrigo Canibano‐Fraile, Laurike Harlaar, Carlos A. dos Santos, Marianne Hoogeveen‐Westerveld, Jeroen A. A. Demmers, Tim Snijders, Philip Lijnzaad, Robert M. Verdijk, Nadine A. M. E. van der Beek, Pieter A. van Doorn, Ans T. van der Ploeg, Esther Brusse, W. W. M. Pim Pijnappel, Gerben J. Schaaf   +13 more
wiley   +1 more source

Role of autophagy in aging: The good, the bad, and the ugly

Aging Cell, Volume 22, Issue 1, January 2023., 2023
Various forms of autophagy. Major types of autophagy include macroautophagy, microautophagy (inside the circle), and chaperone‐mediated autophagy. Autophagy is used for the removal of damaged biomolecules and organelles (outside the circle). Abstract Autophagy (self‐eating) is a conserved catabolic homeostatic process required for cellular metabolic ...
Siamak Tabibzadeh
wiley   +1 more source

Autophagy in health and disease: From molecular mechanisms to therapeutic target

MedComm, Volume 3, Issue 3, September 2022., 2022
Macroautophagy/autophagy is an evolutionally conserved catabolic process induced under various stress conditions to maintain intracellular homeostasis. Dysregulation of autophagy is closely associated with various human diseases. This review will focus on the molecular mechanisms in control of autophagy, the implication of autophagy in various human ...
Guang Lu, Yu Wang, Yin Shi, Zhe Zhang, Canhua Huang, Weifeng He, Chuang Wang, Han‐Ming Shen   +7 more
wiley   +1 more source

Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets. [PDF]

MedComm (2020)
Astrocytes display heterogeneity in various neurological disorders and behavioral neuropsychiatric disorders. Astrocytes influence the progression of neurological diseases through neuroinflammation, oxidative stress, metabolic abnormalities, intercellular interactions, and a spectrum of other pathophysiological processes.
Mao S, Qiao R, Wang Q, Shen L, Li D, Huo X, Wang J, Liu K, Chen W, Zhu T, Zhang B, Leng S, Bai Y.   +12 more
europepmc   +2 more sources

A chromosome‐level genome of Antechinus flavipes provides a reference for an Australian marsupial genus with male death after mating

Molecular Ecology Resources, Volume 22, Issue 2, Page 740-754, February 2022., 2022
Abstract The 15 species of small carnivorous marsupials that comprise the genus Antechinus exhibit semelparity, a rare life‐history strategy in mammals where synchronized death occurs after one breeding season. Antechinus males, but not females, age rapidly (demonstrate organismal senescence) during the breeding season and show promise as new animal ...
Ran Tian, Kai Han, Yuepan Geng, Chen Yang, Chengcheng Shi, Patrick B. Thomas, Coral Pearce, Kate Moffatt, Siming Ma, Shixia Xu, Guang Yang, Xuming Zhou, Vadim N. Gladyshev, Xin Liu, Diana O. Fisher, Lisa K. Chopin, Natália O. Leiner, Andrew M. Baker, Guangyi Fan, Inge Seim   +19 more
wiley   +1 more source