Results 31 to 40 of about 473 (103)

Autophagy at the crossroads of catabolism and anabolism [PDF]

Nature reviews. Molecular cell biology, 2015
Autophagy is a conserved catabolic process that degrades cytoplasmic constituents and organelles in the lysosome. Starvation-induced protein degradation is a salient feature of autophagy but recent progress has illuminated how autophagy, during both ...
Jasvinder Kaur, Jayanta Debnath
semanticscholar   +2 more sources

Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues

Nature Cardiovascular Research
ABSTRACT Diabetic heart disease is highly prevalent and is associated with the early development of impaired diastolic relaxation. The mechanisms of diabetic heart disease are poorly understood and it is a condition for which there are no targeted therapies.
K. M. Mellor, U. Varma, P. Koutsifeli, C. L. Curl, J. V. Janssens, L. J. Daniels, G. B. Bernasochi, A. J. A. Raaijmakers, M. Annandale, X. Li, S. L. James, D. J. Taylor, K. Raedschelders, K. L. Weeks, R. J. Mills, R. G. Parton, X. Hu, J. R. Bell, T. J. O’Brien, R. Katare, E. R. Porrello, J. E. Hudson, R. P. Xiao, J. E. Van Eyk, R. A. Gottlieb, L. M. D. Delbridge   +25 more
semanticscholar   +8 more sources

The “sweet” side of ER-mitochondria contact sites

Communicative & Integrative Biology, 2017
The regions at which the ER and mitochondria come into close proximity, known as ER-mitochondria contact sites provide essential platforms for the exchange of molecules between the two organelles and the coordination of various fundamental cellular ...
Anthi Demetriadou, Anthi Drousiotou, Petros P. Petrou   +2 more
doaj   +2 more sources

Biomedical Implications of Autophagy in Macromolecule Storage Disorders [PDF]

Frontiers in Cell and Developmental Biology, 2019
An imbalance between the production and clearance of macromolecules such as proteins, lipids and carbohydrates can lead to a category of diseases broadly known as macromolecule storage disorders.
Adina Maria Palhegyi, Elena Seranova, Simona Dimova, Sheabul Hoque, Sovan Sarkar   +4 more
doaj   +2 more sources

New Toolset of Reporters Reveals That Glycogen Granules Are Neutral Substrates of Bulk Autophagy in <i>Komagataella phaffii</i>. [PDF]

Int J Mol Sci
Glycogen, a branched polysaccharide organized into glycogen granules (GGs), is delivered from the cytoplasm to the lysosomes of hepatocytes by STBD1-driven selective autophagy (glycophagy).
Wijewantha NV, Battu P, Chen K, Kumar R, Nazarko TY.   +4 more
europepmc   +3 more sources

Targeting Autophagy to Overcome Human Diseases

International Journal of Molecular Sciences, 2019
Autophagy is an evolutionarily conserved cellular process, through which damaged organelles and superfluous proteins are degraded, for maintaining the correct cellular balance during stress insult. It involves formation of double-membrane vesicles, named
M. Condello, E. Pellegrini, M. Caraglia, S. Meschini   +3 more
semanticscholar   +3 more sources

Regulation of autophagy by plant‐based polyphenols: A critical review of current advances in glucolipid metabolic diseases and food industry applications

Food Frontiers, Volume 4, Issue 3, Page 1039-1067, September 2023., 2023
Polyphenol‐mediated metabolic functions of autophagy occur in various tissues. Multiple signaling pathways, receptors, and transcription factors are involved. Polyphenol‐regulated autophagy benefits its application in the food industry. Abstract Autophagy is a complex self‐degrading process, and its imbalance adversely affects local (metabolically ...
Zhenyu Wang, Wei Quan, Maomao Zeng, Zhaojun Wang, Qiuming Chen, Jie Chen, Mark Christian, Zhiyong He   +7 more
wiley   +1 more source

A putative adverse outcome network for neonatal mortality and lower birth weight in rodents: Applicability to per‐ and polyfluoroalkyl substances and relevance to human health

Birth Defects Research, Volume 115, Issue 11, Page 1011-1062, June 15, 2023., 2023
Abstract Background Some per‐ and poly‐fluoroalkyl substances (PFAS) cause neonatal mortality and lower birth weight in rodents. We constructed an Adverse Outcome Pathway (AOP) network for neonatal mortality and lower birth weight in rodents, comprising three putative AOPs.
John M. Rogers, Melissa M. Heintz, Chad M. Thompson, Laurie C. Haws   +3 more
wiley   +1 more source

Muscle glycogen unavailability and fat oxidation rate during exercise: Insights from McArdle disease

The Journal of Physiology, Volume 601, Issue 3, Page 551-566, 1 February 2023., 2023
Abstract figure legend McArdle disease is caused by inherited blockade of glycogen breakdown in skeletal muscle fibres, with subsequent intolerance to most exercise tasks, as well as a substantial impairment of peak aerobic capacity. The present study indicates that the exercise capacity of these patients is mainly sustained by fat oxidation, with ...
Carlos Rodriguez‐Lopez, Alfredo Santalla, Pedro. L Valenzuela, Alberto Real‐Martínez, Mónica Villarreal‐Salazar, Irene Rodriguez‐Gomez, Tomàs Pinós, Ignacio Ara, Alejandro Lucia   +8 more
wiley   +1 more source

Lysosomal glycogen accumulation in Pompe disease results in disturbed cytoplasmic glycogen metabolism

Journal of Inherited Metabolic Disease, Volume 46, Issue 1, Page 101-115, January 2023., 2023
Abstract Pompe disease is an inherited metabolic myopathy caused by deficiency of acid alpha‐glucosidase (GAA), resulting in lysosomal glycogen accumulation. Residual GAA enzyme activity affects disease onset and severity, although other factors, including dysregulation of cytoplasmic glycogen metabolism, are suspected to modulate the disease course ...
Rodrigo Canibano‐Fraile, Laurike Harlaar, Carlos A. dos Santos, Marianne Hoogeveen‐Westerveld, Jeroen A. A. Demmers, Tim Snijders, Philip Lijnzaad, Robert M. Verdijk, Nadine A. M. E. van der Beek, Pieter A. van Doorn, Ans T. van der Ploeg, Esther Brusse, W. W. M. Pim Pijnappel, Gerben J. Schaaf   +13 more
wiley   +1 more source