Results 71 to 80 of about 513,877 (318)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Radial Distribution of Production Rates, Loss Rates and Densities Corresponding to Ion Masses <=40 amu in the Inner Coma of Comet Halley: Composition and Chemistry

, 2005
In this paper we have studied the chemistry of C, H, N, O, and S compounds corresponding to ions of masses
Allen, Altwegg, Altwegg, Altwegg, Anicich, Anicich, Anicich, Anil Bhardwaj, Balsiger, Balsiger, Bhardwaj, Bhardwaj, Bhardwaj, Bhardwaj, Bhardwaj, Bhardwaj, Bhardwaj, Bhardwaj, Boice, Crovisier, Eberhardt, Eberhardt, Eberhardt, Eberhardt, Festou, Festou, Geiss, Gringauz, Haberli, Haberli, Haider, Haider, Huebner, Huebner, Huebner, Ip, Khare, Korth, Krankowsky, Marconi, Marconi, Marconi, Marconi, Meier, Meier, Mendis, Michael, Millar, Mitchell, Mitchell, Mitchell, Murad, Rao, Reme, S.A. Haider, Schmidt, Slanina, Wegmann, Wegmann   +58 more
core   +1 more source

Molecular ions in the protostellar shock L1157-B1 [PDF]

, 2014
We perform a complete census of molecular ions with an abundance larger than 1e-10 in the protostellar shock L1157-B1 by means of an unbiased high-sensitivity survey obtained with the IRAM-30m and Herschel/HIFI. By means of an LVG radiative transfer code
Bachiller, R., Ceccarelli, C., Codella, C., Lefloch, B., Podio, L.   +4 more
core   +2 more sources

Numerical analysis of reactive turbulent flow in the thrust chamber of RD-108 engine rocket

Defence Technology, 2019
Combustion chamber modeling and simulation of the liquid propellant engine with kerosene as fuel and liquid oxygen as an oxidizer in the turbulent flow field are performed by CFD technique.
Seyed Reza Taghavi, Mohammad Ali Dehnavi, Ali Ghafouri   +2 more
doaj  

Langevin Dynamics with Variable Coefficients and Nonconservative Forces: From Stationary States to Numerical Methods

Entropy, 2017
Langevin dynamics is a versatile stochastic model used in biology, chemistry, engineering, physics and computer science. Traditionally, in thermal equilibrium, one assumes (i) the forces are given as the gradient of a potential and (ii) a fluctuation ...
Matthias Sachs, Benedict Leimkuhler, Vincent Danos   +2 more
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Photochemistry in the arctic free troposphere: NOx budget and the role of odd nitrogen reservoir recycling [PDF]

, 2003
The budget of nitrogen oxides (NOx) in the arctic free troposphere is calculated with a constrained photochemical box model using aircraft observations from the Tropospheric O3 Production about the Spring Equinox (TOPSE) campaign between February and May.
Atlas, E, Blake, D, Coffey, M, Flocke, F, Fried, A, Heikes, B, Lefer, B, Madronich, S, Ridley, B, Shetter, R, Stroud, C, Talbot, B, Weinheimer, A, Wert, B   +13 more
core   +1 more source