Doubling the diagnostic rate of at-risk metabolic dysfunction-associated steatohepatitis-leave no one behind. [PDF]
Abdelgadir E +4 more
europepmc +1 more source
ABSTRACT Background Lichen sclerosus is a chronic, inflammatory, scarring disease of the skin that manifests mostly in the genital region. Objective We studied the histomorphological characteristics, grade, and pattern of inflammation in male pediatric patients with lichen sclerosus.
Valerie Flammang +10 more
wiley +1 more source
Heterogeneous outcomes in metabolic dysfunction-associated steatotic liver disease/steatohepatitis with type 2 diabetes: Rethinking risk and management approaches. [PDF]
Zheng ZX, Huang SM.
europepmc +1 more source
This study identifies biliary glutathione concentration during normothermic machine perfusion as a potential biomarker for biliary viability. Increasing GSH levels correlate with fewer biliary complications post‐transplant, supporting its role in assessing graft quality and improving decision‐making in liver transplantation.
Christina Bogensperger +10 more
wiley +1 more source
AI in steatohepatitis diagnostics: precision beyond the microscope. [PDF]
Ejaz A +4 more
europepmc +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Novel Choline-Deficient and 0.1%-Methionine-Added High-Fat Diet Induces Burned-Out Metabolic-Dysfunction-Associated Steatohepatitis with Inflammation by Rapid Immune Cell Infiltration on Male Mice [PDF]
Takatoshi Sakaguchi +6 more
openalex +1 more source
SPP1 was identified as a key driver of intratumoral fibrosis and hepatocellular carcinoma (HCC) progression through transcriptomic, histological, and functional analyses. Mechanistically, SPP1 promotes HSC activation and fibrosis via the SPP1–CD44–GLI1 axis, and pharmacologic inhibition of Hedgehog signaling effectively reduces tumor growth and ...
Atsushi Nara +16 more
wiley +1 more source
Retatrutide improves steatohepatitis in an accelerated mouse model of diet-induced steatohepatitis with a fructose binge. [PDF]
Viebahn GK +10 more
europepmc +1 more source

