Results 211 to 220 of about 170,525 (342)

Tumor‐infiltrating B cells participate in shaping the immunosuppressive microenvironment in solid tumors

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Tumor‐infiltrating B cells (TIBs) exhibit dual roles in the tumor microenvironment (TME) of solid tumors. While they can enhance anti‐tumor immunity through antibody production and immune activation, certain subsets—such as regulatory B cells (Bregs) and immunosuppressive plasma cells—contribute to immune evasion by secreting inhibitory ...
Zhitong Li   +5 more
wiley   +1 more source

Evaluation of the Pharmacokinetics, Disposition, and Metabolism of Miricorilant, a Novel Glucocorticoid Receptor Modulator for the Treatment of Metabolic Dysfunction‐Associated Steatohepatitis in Nonclinical and Clinical Studies

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Miricorilant is a novel selective glucocorticoid receptor (GR) modulator with mixed agonist/antagonist effects at the GR and modest antagonism at the mineralocorticoid receptor that is being developed for the treatment of metabolic dysfunction‐associated steatohepatitis.
Hazel J. Hunt   +3 more
wiley   +1 more source

Effects of rifaximin in fructose-induced steatohepatitis in rats. [PDF]

open access: yesHepatol Forum
Celik NC   +6 more
europepmc   +1 more source

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

open access: yesThe Lancet, 2015
B. Neuschwander‐Tetri   +17 more
semanticscholar   +1 more source

Fat‐Corrected Non‐Gaussian Diffusion MRI for Liver Fibrosis Assessment in Metabolic Dysfunction‐Associated Steatotic Liver Disease

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background In patients with metabolic dysfunction‐associated steatotic liver disease (MASLD), non‐Gaussian diffusion—weighted imaging (DWI) has been proposed for the diagnosis of liver fibrosis, but its measurement is partially confounded by steatosis.
Omaïma Saïd   +8 more
wiley   +1 more source

TRIB3 Is a Hub Gene in Steatohepatitis and Aggravates Lipid Deposition and Inflammation in Hepatocytes

open access: yesDiabetes, Metabolic Syndrome and Obesity
Wen Xia,1,* Li Xiao,1,* Huan Cheng,1 Yuwei Feng2 1Department of Cardiovascular Medicine, Wuhan No.1 Hospital, Wuhan, Hubei, People’s Republic of China; 2Department of Hepatology with Integrated Traditional Chinese and Western Medicine, Hubei No.3
Xia W, Xiao L, Cheng H, Feng Y
doaj  

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