Results 251 to 260 of about 125,716 (297)

Association Between Left Ventricular Global Longitudinal Strain and Hepatic Inflammation and Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]

Diagnostics (Basel)
Hüning AR, Egypto Rosa VE, Piardi DS, Assis DVR, Ferreira TV, Griseli L, Moreira FC, Carli LA, Hartmann CR, Coral GP, Sampaio RO, Vieira MLC, Tarasoutchi F, Leães PE, Mattos AA.   +14 more
europepmc   +1 more source

Hepatic GCGR is required for the superior weight loss and metabolic effects of a structurally related analogue of the dual GCGR/GLP‐1R agonist survodutide in mice

Diabetes, Obesity and Metabolism, EarlyView.
Fen Long, Tenagne D. Challa, Vissarion Efthymiou, Manuel Klug, Thomas Klein, Heike Neubauer, Christian Wolfrum, Carla Horvath   +7 more
wiley   +1 more source

Young Adults Are at Highest Risk of Liver Fibrosis and Mortality Associated With Steatotic Liver Disease With Metabolic Dysfunction and Alcohol Consumption

Hepatology Research, EarlyView.
ABSTRACT Background Alcohol consumption in patients with steatotic liver disease (SLD) with metabolic dysfunction (MD) increases the risk of liver fibrosis and mortality. However, whether these risks vary by age remains poorly understood. Methods Data from NHANES‐III were used, including participants with data on SLD, alcohol consumption, and mortality.
Jesse Pustjens, Laurens A. van Kleef, Zobair M. Younossi, Christophe Moreno, Harry L. A. Janssen, Maja Thiele, Willem P. Brouwer   +6 more
wiley   +1 more source

Intravascular Hepatocyte Lipid Droplets Are Commonly Present in Hepatic Sinusoids, Portal Venules, and Central Veins in MASH. [PDF]

Gastro Hep Adv
Ioannou GN, Savard C, Dempsey JL, Carr RM, Lee SP.   +4 more
europepmc   +1 more source

Preliminary In Silico Evaluation of Potential Therapeutics for Non-Alcoholic Steatohepatitis (NASH) using Molecular Docking and Pharmacokinetics Analysis

Sudarsna B, Gokulkrishnan A
openalex   +2 more sources

If treating obesity with GLP‐1‐based therapies protects the heart, could it also prevent cancer or improve cancer outcomes? The case for randomized trials

Diabetes, Obesity and Metabolism, EarlyView.
Anastasios Tentolouris, Ioannis Ntanasis‐Stathopoulos   +1 more
wiley   +1 more source

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

Hepatology Research, EarlyView.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura, Aya Naiki‐Ito, Xiaochen Kuang, Akihiro Murakami, Masayuki Komura, Takanori Suzuki, Hiroyuki Kato, Yuko Nagayasu, Kentaro Matsuura, Kei Fujiwara, Hiromi Kataoka, Satoru Takahashi   +11 more
wiley   +1 more source

Metabolic and epigenetic abnormalities cause hepatic fibrogenesis in metabolic dysfunction-associated steatohepatitis model mice. [PDF]

J Biol Chem
Miura A, Ikeda S, Kono Y, Kawate K, Hosono T, Seki T.   +5 more
europepmc   +1 more source

Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome‐Related Disorders

Hepatology Research, EarlyView.
It is speculated that the onset of obesity‐related diseases follows the sequence of obesity → SLD → MetS‐related diseases. In this study, the contribution of SLD to each MetS‐related disease was large for T2D and hypertension and SLD contributed to the onset and new onset of the disease by the 7‐year follow‐up.
Yoshihiro Kamada, Makoto Fujii, Hitoshi Nishizawa, Shiro Fukuda, Makoto Yamada, Iichiro Shimomura, Eiji Miyoshi   +6 more
wiley   +1 more source

Novel prolyl endopeptidase inhibitor from <i>Myricaria germanica</i> alleviates steatohepatitis. [PDF]

RSC Adv
Ullah K, Azam T, Sammad A, Ahmed T, Wadood A, Ali MF, Mushraf GM, Shaheen Siddiqui B, Li YX.   +8 more
europepmc   +1 more source