Results 21 to 30 of about 125,716 (297)

Bariatric Surgery Provides Long-term Resolution of Nonalcoholic Steatohepatitis and Regression of Fibrosis.

Gastroenterology, 2020
BACKGROUND & AIMS Studies are needed to determine the long-term effects of bariatric surgery for patients with nonalcoholic steatohepatitis (NASH). We evaluated sequential liver biopsies, collected the time of bariatric surgery and 1 and 5 years later ...
G. Lassailly, R. Caiazzo, Line-Carolle Ntandja-Wandji, V. Gnemmi, G. Baud, Hélène Verkindt, Massih Ningarhari, A. Louvet, E. Leteurtre, V. Raverdy, S. Dharancy, F. Pattou, P. Mathurin   +12 more
semanticscholar   +1 more source

Integration analysis identifies the role of metallothionein in the progression from hepatic steatosis to steatohepatitis

Frontiers in Endocrinology, 2022
BackgroundNon-alcoholic fatty liver disease (NAFLD), a metabolic disorder that develops from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), has become an epidemic of chronic liver dysfunction worldwide. However, mechanisms that
Xiaoya Li, Shaoping Zhong, Yifan Sun, Xinmei Huang, Yue Li, Lihong Wang, Yueyue Wu, Min Yang, Hai-Xin Yuan, Jun Liu, Shufei Zang   +10 more
doaj   +1 more source

Obeticholic acid and ferrostatin-1 differentially ameliorate non-alcoholic steatohepatitis in AMLN diet-fed ob/ob mice

Frontiers in Pharmacology, 2022
Introduction: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are common chronic liver diseases with limited treatment options.Methods: Ob/ob mice (6 weeks old) were fed with the Control diet or amylin liver NASH (AMLN)
Shengjie Li, Aoxiang Zhuge, Kaicen Wang, Jiafeng Xia, Qiangqiang Wang, Shengyi Han, Jian Shen, Lanjuan Li, Lanjuan Li   +8 more
doaj   +1 more source

Genetic predictors and pathophysiological features of non-alcoholic fat liver disease

Медицинский совет, 2021
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in highly developed countries. The risk of developing NAFLD and associated complications varies greatly among people of different nationalities and is determined by ...
O. V. Smirnova, O. L. Moskalenko, E. V. Kasparov, I. E. Kasparova,   +3 more
doaj   +1 more source

Pathogenesis of Nonalcoholic Steatohepatitis: An Overview

Hepatology Communications, 2020
Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous group of liver diseases characterized by the accumulation of fat in the liver. The heterogeneity of NAFLD is reflected in a clinical and histologic spectrum where some patients develop isolated ...
G. Parthasarathy, Xavier S. Revelo, H. Malhi   +2 more
semanticscholar   +1 more source

Metabolic dysfunction-associated fatty liver disease and metabolic-associated steatohepatitis: a review of pathogenesis and potential pharmacological targets

Fiyz̤, 2022
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most common liver diseases that results from excess fat accumulation in the hepatocytes. The progression of steatosis to hepatocellular necrosis and inflammation leads
Samaneh Olapour, Hamid Yaghooti
doaj  

PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH)

Biology, 2022
Simple Summary In the context of liver disease, one of the more growing public health problems is the transition from simple steatosis to non-alcoholic steatohepatitis.
S. Todisco, A. Santarsiero, Paolo Convertini, Giulio Francesco De Stefano, M. Gilio, V. Iacobazzi, V. Infantino   +6 more
semanticscholar   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease

Frontiers in Physiology, 2012
Alcoholic liver disease (ALD) encompasses hepatic steatosis, which may progress to alcoholic hepatitis, fibrosis, and cirrhosis. It remains a leading cause of morbidity and mortality in the US and worldwide.
Phillipp eHartmann, Wei-Chung eChen, Bernd eSchnabl   +2 more
doaj   +1 more source