Results 141 to 150 of about 236,526 (353)

Metabolic dysfunction‐associated fatty liver disease and excessive alcohol consumption are both independent risk factors for mortality

Hepatology, EarlyView., 2022
Visualisation of the study desgin, main results and key findings. Abstract Background and Aims MAFLD often cooccurs with excessive alcohol consumption, while its prognostic value in this group remains unclear. We aimed to study the mortality risk of MAFLD in relation to excessive alcohol consumption and its potential interactions.
Laurens A. van Kleef, Robert J. de Knegt, Willem Pieter Brouwer   +2 more
wiley   +1 more source

Morphometric analysis of hepatic steatosis in chronic hepatitis C infection

The Saudi Journal of Gastroenterology, 2009
Background/Aims: To quantitatively assess steatosis by a morphometric method and to study its relationship with other histological features of chronic hepatitis C (CHC). This was a comparative descriptive study.
Zubair Alia, Jamal Shahid, Mubarik Azhar
doaj  

Detecting altered hepatic lipid oxidation by MRI in an animal model of MASLD

Cell Reports Medicine
Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing annually and affects over a third of US adults. MASLD can progress to metabolic dysfunction-associated steatohepatitis (MASH), characterized by severe ...
Marc McLeod, Mario C. Chang, Anna Rushin, Mukundan Ragavan, Rohit Mahar, Gaurav Sharma, Arshee Badar, Anthony Giacalone, Max E. Glanz, Vinay R. Malut, Dalton Graham, Nishanth E. Sunny, James A. Bankson, Kenneth Cusi, Matthew E. Merritt   +14 more
doaj   +1 more source

Inverse association of circulating SIRT1 and adiposity. A study on underweight, normal weight, and obese patients [PDF]

, 2018
Context: Sirtuins (SIRTs) are NAD+-dependent deacetylases, cellular sensors to detect energy availability, and modulate metabolic processes. SIRT1, the most studied family member, influences a number of tissues including adipose tissue.
Barbaro G, BASCIANI, Sabrina, CONTINI, SAVINA, DI GIORGIO, MARIA ROSARIA, Donini LM, Genco A, GNESSI, Lucio, Lenzi A, LUBRANO, Carla, MARIANI, Stefania, Persichetti A, Poggiogalle E, Rosano A, SAN MARTINI, Pietro, SARNICOLA, Antonio   +14 more
core   +1 more source

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice[S]

Journal of Lipid Research, 2013
The objective of this study was to examine the mechanism by which conjugated linoleic acid (CLA) reduces body fat. Young male mice were fed three combinations of fatty acids at three doses (0.06%, 0.2%, and 0.6%, w/w) incorporated into AIN76 diets for 7 ...
Wan Shen, Chia-Chi Chuang, Kristina Martinez, Tanya Reid, J. Mark Brown, Lin Xi, Lindsay Hixson, Robin Hopkins, Joseph Starnes, Michael McIntosh   +9 more
doaj   +1 more source

Supplementary Figures 9-10 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors

, 2023
Barbara R. Tschida, Nuri A. Temiz, Timothy P. Kuka, Lindsey A. Lee, Jesse D. Riordan, Carlos A. Tierrablanca, Robert Hullsiek, Sandra Wagner, Wendy A. Hudson, Michael A. Linden, Khalid Amin, Pauline J. Beckmann, Rachel A. Heuer, Aaron L. Sarver, Ju Dong Yang, Lewis R. Roberts, Joseph H. Nadeau, Adam J. Dupuy, Vincent W. Keng, David A. Largaespada   +19 more
openalex   +2 more sources

Chronic PET‐Microplastic Exposure: Disruption of Gut–Liver Homeostasis and Risk of Hepatic Steatosis

Advanced Science, EarlyView.
Chronic exposure to environmentally relevant PET microplastics disrupts gut–liver homeostasis, leading to hepatic steatosis, early fibrosis, and altered gut microbiota. These effects signal metabolic imbalance and gut–liver axis impairment, emphasizing chronic microplastic ingestion as an emerging environmental health risk linked to non‐communicable ...
Surye Park, Min‐Ji Kim, Jae‐Ho Shin, Eunsoo Kim, Myeongjoo Son, Seungjun Lee   +5 more
wiley   +1 more source

Hepatobiliary diseases in patients with human immunodeficiency virus (HIV) treated with non highly active anti-retroviral therapy: frequency and clinical manifestations

Annals of Hepatology, 2005
Objective: To evaluate the frequency of hepatobiliary diseases and the clinical manifestations in patients with HIV treated with non highly active anti-retroviral therapy. Methods: Seven hundred clinical records of patients with HIV infection who entered
Javier Lizardi-Cervera, Luis E. Soto Ramírez, Jorge Luis Poo, Misael Uribe   +3 more
doaj   +1 more source