Results 191 to 200 of about 236,526 (353)

Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation. [PDF]

open access: yes, 2019
The decrease in incretin effects is an important etiologic component of type 2 diabetes with unknown mechanisms. In an attempt to understand obesity-induced changes in liver oxygen homeostasis, we found that liver HIF-1α expression was increased mainly ...
Bandyopadhyay, Guatam K   +3 more
core  

Incidence of major cardiovascular events in patients with metabolic dysfunction‐associated steatotic liver disease in the general population

open access: yesEuropean Journal of Heart Failure, EarlyView.
Aims Major adverse cardiovascular events (MACE) related to cardiovascular disease are a major cause of death in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). We explored the impact of MASLD on incident MACE and overall mortality in the general population in Germany.
Yvonne Huber   +15 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

open access: yesEpilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury   +3 more
wiley   +1 more source

Investigation of non-alcoholic steatohepatitis in labidochromis caeruleus and xiphophorus hellerii [PDF]

open access: yesEurasian Journal of Veterinary Sciences
Aim: "Labidochromis caeruleus" and "Xiphophorus hellerii" are commercially important aquarium ornamental fish. The aim of this study, upon the discovery that these species died by showing various clinical signs in optimum conditions and standard feding ...
Mustafa Ünal Boyraz   +2 more
doaj  

Gut‐Targeted Nutraceutical Delivery: Engineering Microbiome‐Responsive Nutraceutical Interfaces

open access: yesFood Bioengineering, EarlyView.
ABSTRACT The gut microbiome plays a central role in maintaining host health, influencing immunity, metabolism, epithelial integrity, and the gut–brain axis. Dysbiosis of this complex microbial ecosystem is implicated in a variety of chronic diseases, including inflammatory bowel disease, metabolic syndrome, and neurological disorders.
Jeyavelkumaran Renukadevi   +4 more
wiley   +1 more source

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity.

open access: yesJournal of Clinical Investigation, 2006
Hajime Kanda   +10 more
semanticscholar   +1 more source

Management and Modification of Flavonoids Against Nonalcoholic Fatty Liver Disease

open access: yesFood Bioengineering, EarlyView.
Flavonoids protect against NAFLD by enhancing mitochondrial function, reducing ER stress, and modulating gut microbiota. Structural modifications improve flavonoid efficacy, offering a promising dietary strategy for NAFLD management. ABSTRACT Flavonoids are small bioactive molecules commonly found in plant‐derived foods, exhibiting antioxidant, anti ...
Weidong Bai   +6 more
wiley   +1 more source

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