Results 31 to 40 of about 236,526 (353)

The Rbm38-p63 feedback loop is critical for tumor suppression and longevity. [PDF]

, 2018
The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in-turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop.
Chen, Mingyi, Chen, Xinbin, Flores, Elsa, Jiang, Yuqian, Xu, Enshun, Zhang, Jin   +5 more
core   +1 more source

Evaluation of polygenic determinants of non-alcoholic fatty liver disease (NAFLD) by a candidate genes resequencing strategy [PDF]

, 2018
NAFLD is a polygenic condition but the individual and cumulative contribution of identified genes remains to be established. To get additional insight into the genetic architecture of NAFLD, GWAS-identified GCKR, PPP1R3B, NCAN, LYPLAL1 and TM6SF2 genes ...
Angelico F, Angeloni A, Arca M, Bailetti D, Baratta F, Belardinilli F, Ceci F, D'Erasmo L, De Masi B, Del Ben M, Di Costanzo A, Giannini G, Girelli G, Montali A, Pastori D, Polimeni L, Sponziello M   +16 more
core   +1 more source

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

Science, 2019
Ceramides in focus Excess calorie intake can ultimately lead to a metabolic syndrome that interferes with fat or lipid metabolism. There are many different types of lipids, and it has been widely debated which are the true culprits underlying metabolic ...
Bhagirath Chaurasia, Trevor S. Tippetts, Rafael Mayoral Monibas, Jinqi Liu, Ying Li, Liping Wang, Joseph L. Wilkerson, C. R. Sweeney, R. F. Pereira, D. H. Sumida, J. Maschek, J. Cox, V. Kaddai, G. Lancaster, M. M. Siddique, Annelise M. Poss, M. Pearson, S. Satapati, Heather H. Zhou, D. McLaren, S. Previs, Ying Chen, Y. Qian, Aleksandr Petrov, Margaret S. Wu, Xiaolan Shen, Jun Yao, C. Nunes, A. Howard, Liangsu Wang, M. Erion, J. Rutter, J. Rutter, W. Holland, D. Kelley, S. Summers   +35 more
semanticscholar   +1 more source

The prevalence of nonalcoholic liver steatosis in patients with type 2 diabetes mellitus in the Czech Republic

Biomedical Papers, 2015
Aims: Nonalcoholic fatty liver disease (NAFLD) is associated with components of the metabolic syndrome (MS) but the prevalence of NAFLD in the Czech Republic is unknown. The aim of this study was to assess the latter in patients with type 2 diabetes (DM2)
Karel Dvorak, Radvan Hainer, Jaromir Petrtyl, Miroslav Zeman, Tomas Vareka, Ales Zak, Renata Sroubkova, Tomislav Svestka, Libor Vitek, Radan Bruha   +9 more
doaj   +1 more source

DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease. [PDF]

, 2019
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of chronic liver disorders among adults, children, and adolescents, and a growing epidemic, worldwide.
Besaratinia, Ahmad, Tommasi, Stella
core   +1 more source

Increased Oxygen Desaturation Time During Sleep Is a Risk Factor for NASH in Patients With Obstructive Sleep Apnea: A Prospective Cohort Study

Frontiers in Medicine, 2022
IntroductionGiven that obstructive sleep apnea (OSA) is commonly associated with metabolic disorders, in this prospective study, we sought to determine the prevalence and risk factors for hepatosteatosis, non-alcoholic steatohepatitis (NASH), and ...
Pedro Landete, Pedro Landete, Carlos Ernesto Fernández-García, Beatriz Aldave-Orzaiz, Marta Hernández-Olivo, Carmen M. Acosta-Gutiérrez, Enrique Zamora-García, Enrique Zamora-García, Julio Ancochea, Julio Ancochea, Águeda González-Rodríguez, Águeda González-Rodríguez, Carmelo García-Monzón   +12 more
doaj   +1 more source

Deficiency of the purinergic receptor 2X7 attenuates nonalcoholic steatohepatitis induced by high-fat diet. possible role of the NLRP3 Inflammasome [PDF]

, 2017
Molecular mechanisms driving transition from simple steatosis to nonalcoholic steatohepatitis (NASH), a critical step in the progression of nonalcoholic fatty liver disease (NAFLD) to cirrhosis, are poorly defined. This study aimed at investigating the
Blasetti Fantauzzi, Claudia, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe, Rossi, Chiara, Santini, Eleonora, Solini, Anna   +6 more
core   +3 more sources

Comparison of fatty liver index with fibroscan in non-alcoholic fatty liver disease

Journal of Family Medicine and Primary Care
Context: Non-alcoholic fatty liver disease (NAFLD) is an escalating global health issue. Early detection and precise diagnosis are imperative for effective management.
Marium Ahmed, Rabeeya Saeed, Lubna Kamani, Noureen Durrani, Faraz Ahmed   +4 more
doaj   +1 more source

Repercussions of low fructose-drinking water in male rats

Anais da Academia Brasileira de Ciências, 2019
Fructose consumption has increased worldwide, and it has been associated with the development of metabolic diseases such as insulin resistance (IR) and steatosis.
CAROLINA A. MIRANDA, TATIELE E. SCHÖNHOLZER, EDUARDO KLÖPPEL, YURI K. SINZATO, GUSTAVO T. VOLPATO, DÉBORA C. DAMASCENO, KLEBER E. CAMPOS   +6 more
doaj   +1 more source

The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation

Medicina
The gastrointestinal tract is inhabited by the gut microbiota. The main phyla are Firmicutes and Bacteroidetes. In non-alcoholic fatty liver disease, now renamed metabolic dysfunction-associated fatty liver disease (MAFLD), an alteration in Firmicutes ...
Ludovico Abenavoli, Maria Luisa Gambardella, Giuseppe Guido Maria Scarlata, Ilaria Lenci, Leonardo Baiocchi, Francesco Luzza   +5 more
doaj   +1 more source