Results 31 to 40 of about 240,641 (402)

The Rbm38-p63 feedback loop is critical for tumor suppression and longevity. [PDF]

, 2018
The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in-turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop.
Chen, Mingyi, Chen, Xinbin, Flores, Elsa, Jiang, Yuqian, Xu, Enshun, Zhang, Jin   +5 more
core   +1 more source

Genetic Polymorphisms and Diversity in Nonalcoholic Fatty Liver Disease (NAFLD): A Mini Review

Biomedicines, 2022
Nonalcoholic fatty liver disease (NAFLD) is a common liver disease with a wide spectrum of liver conditions ranging from hepatic steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma.
Siti Aishah Sulaiman, Vicneswarry Dorairaj, Muhammad Nafiz Haidi Adrus   +2 more
doaj   +1 more source

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

Science, 2019
Ceramides in focus Excess calorie intake can ultimately lead to a metabolic syndrome that interferes with fat or lipid metabolism. There are many different types of lipids, and it has been widely debated which are the true culprits underlying metabolic ...
Bhagirath Chaurasia, Trevor S. Tippetts, Rafael Mayoral Monibas, Jinqi Liu, Ying Li, Liping Wang, Joseph L. Wilkerson, C. R. Sweeney, R. F. Pereira, D. H. Sumida, J. Maschek, J. Cox, V. Kaddai, G. Lancaster, M. M. Siddique, Annelise M. Poss, M. Pearson, S. Satapati, Heather H. Zhou, D. McLaren, S. Previs, Ying Chen, Y. Qian, Aleksandr Petrov, Margaret S. Wu, Xiaolan Shen, Jun Yao, C. Nunes, A. Howard, Liangsu Wang, M. Erion, J. Rutter, J. Rutter, W. Holland, D. Kelley, S. Summers   +35 more
semanticscholar   +1 more source

Alcoholic hepatitis and metabolic disturbance in female mice: a more tractable model than Nrf2−/− animals

Disease Models & Mechanisms, 2020
Alcoholic hepatitis (AH) is the dramatic acute presentation of alcoholic liver disease, with a 15% mortality rate within 28 days in severe cases. Research into AH has been hampered by the lack of effective and reproducible murine models that can be ...
Lozan Sheriff, Reenam S. Khan, Raquel Saborano, Richard Wilkin, Nguyet-Thin Luu, Ulrich L. Gunther, Stefan G. Hubscher, Philip N. Newsome, Patricia F. Lalor   +8 more
doaj   +1 more source

Vibration-Controlled Transient Elastography and Controlled Attenuation Parameter for the Diagnosis of Liver Steatosis and Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

Diagnostics, 2021
Vibration-Controlled Transient Elastography (VCTE) with Controlled Attenuation Parameter (CAP) is a widely used non-invasive technique for concomitant assessment of liver steatosis and fibrosis in patients with nonalcoholic fatty liver disease (NAFLD ...
Sebastian Zenovia, Carol Stanciu, Catalin Sfarti, Ana-Maria Singeap, Camelia Cojocariu, Irina Girleanu, Mihaela Dimache, Stefan Chiriac, Cristina Maria Muzica, Robert Nastasa, Laura Huiban, Tudor Cuciureanu, Anca Trifan   +12 more
doaj   +1 more source

Effect of Empagliflozin on Liver Steatosis and Fibrosis in Patients With Non-Alcoholic Fatty Liver Disease Without Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial

Advances in Therapy, 2020
Despite the high prevalence of non-alcoholic fatty liver disease (NAFLD) and its associated co-morbidities, no efficient treatment in a high percentage of individuals is available. Beneficial effects of sodium–glucose co-transporter 2 inhibitors on fatty
H. Taheri, M. Malek, F. Ismail-Beigi, F. Zamani, M. Sohrabi, Mohammad Reza babaei, M. Khamseh   +6 more
semanticscholar   +1 more source

Banff consensus recommendations for steatosis assessment in donor livers

Hepatology, 2021
No consensus criteria or approaches exist regarding assessment of steatosis in the setting of human donor liver suitability for transplantation. The Banff Working Group on Liver Allograft Pathology undertook a study to determine the consistency with ...
D. Neil, M. Minervini, Maxwell L. Smith, S. Hubscher, Elizabeth M. Brunt, A. Demetris   +5 more
semanticscholar   +1 more source

Metabolite Profile Characterization of Cyanobacterial Strains with Bioactivity on Lipid Metabolism Using In Vivo and In Vitro Approaches

Marine Drugs, 2023
Cyanobacteria have demonstrated their therapeutic potential for many human diseases. In this work, cyanobacterial extracts were screened for lipid reducing activity in zebrafish larvae and in fatty-acid-overloaded human hepatocytes, as well as for ...
Tiago Ribeiro, Kristín Jónsdóttir, Rene Hernandez-Bautista, Natália Gonçalves Silva, Begoña Sánchez-Astráin, Afshin Samadi, Finnur F. Eiriksson, Margrét Thorsteinsdóttir, Siegfried Ussar, Ralph Urbatzka   +9 more
doaj   +1 more source

Quantitative ultrasound approaches for diagnosis and monitoring hepatic steatosis in nonalcoholic fatty liver disease

Theranostics, 2020
Nonalcoholic fatty liver disease is a major global health concern with increasing prevalence, associated with obesity and metabolic syndrome. Recently, quantitative ultrasound-based imaging techniques have dramatically improved the ability of ultrasound ...
Amir M Pirmoazen, Aman Khurana, A. El Kaffas, A. Kamaya   +3 more
semanticscholar   +1 more source

Relationship between adipose tissue dysfunction, Vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease [PDF]

, 2017
Non-alcoholic fatty liver disease ( NAFLD) is the most common chronic liver disease worldwide. Its pathogenesis is complex and not yet fully understood.
BARCHETTA, ILARIA, BARONI, Marco Giorgio, BERTOCCINI, LAURA, CAROTTI, Simone, CAVALLO, Maria Gisella, CIMINI, FLAVIA AGATA, Morini, Sergio, VESPASIANI GENTILUCCI, UMBERTO   +7 more
core   +1 more source