Results 21 to 30 of about 189,252 (309)

Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice

Molecular Therapy: Nucleic Acids, 2022
Fibroblast growth factor 21 (FGF21) is a promising therapeutic agent for treatment of type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH). We show that therapeutic levels of FGF21 were achieved following subcutaneous (s.c.) administration of ...
Stefano Bartesaghi, Kristina Wallenius, Daniel Hovdal, Mathias Liljeblad, Simonetta Wallin, Niek Dekker, Louise Barlind, Nigel Davies, Frank Seeliger, Maria Sörhede Winzell, Sima Patel, Matt Theisen, Luis Brito, Nils Bergenhem, Shalini Andersson, Xiao-Rong Peng   +15 more
doaj   +1 more source

Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease. [PDF]

, 2017
BackgroundReliable non-invasive markers to characterize inflammation, hepatocellular ballooning, and fibrosis in nonalcoholic fatty liver disease (NAFLD) are lacking.
Ann Scheimann, Anna Mae Diehl, Bradley Aouizerat, David Glidden, Emily R. Perito, Jean P. Molleston, Jeffrey B. Schwimmer, Joel E. Lavine, Karen F. Murray, Katherine P. Yates, Nathan M. Bass, null null, Philip Rosenthal, Ryan Gill, Veeral Ajmera   +14 more
core   +1 more source

Internal Ileal Diversion as Treatment for Progressive Familial Intrahepatic Cholestasis Type 1-Associated Graft Inflammation and Steatosis after Liver Transplantation

Children, 2022
Background: Progressive Familial Intrahepatic cholestasis type I (PFIC1) is a rare congenital hepatopathy causing cholestasis with progressive liver disease.
Anna M. Kavallar, Franka Messner, Stefan Scheidl, Rupert Oberhuber, Stefan Schneeberger, Denise Aldrian, Valeria Berchtold, Murat Sanal, Andreas Entenmann, Simon Straub, Anna Gasser, Andreas R. Janecke, Thomas Müller, Georg F. Vogel   +13 more
doaj   +1 more source

Multifocal nodular steatosis

Journal of the Belgian Society of Radiology, 2013
Background: A 62-year-old male with no medical history underwent an ultrasonography of the abdomen because of changed bowel habits and abdominal pain. CT-scan of the abdomen was performed, which initially suggested liver metastases. However, no primary tumor could be identified.
Fassaert, TA, Ranschaert, ER, Jong, MDF de, Dubelaar, I   +3 more
openaire   +5 more sources

Insulin resistance associates with hepatic lobular inflammation in subjects with obesity [PDF]

, 2019
Purpose: Obese subjects with nonalcoholic fatty liver disease (NAFLD) are more prone to develop additional metabolic disturbances such as systemic insulin resistance (IR) and type 2 diabetes.
Batens, Arsène-Hélène, Bekaert, Marlies, Geerts, Anja, Hoorens, Anne, Lapauw, Bruno, Ouwens, Margriet, Shadid, Samiah, Van de Velde, Frederique, Van Nieuwenhove, Yves   +8 more
core   +1 more source

An Effect of Ursodeoxycholic Acid on Inflammation, Steatosis and Liver Fibrosis and Atherogenesis Factors in Patients with Non-Alcoholic Fatty Liver Disease: Results of the USPEH Study

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2020
Aim. To evaluate effects of ursodeoxycholic acid (UDCA) on inflammation, steatosis and liver fibrosis and atherogenesis factors in patients with non-alcoholic fatty liver disease (NAFLD).Materials and methods.
M. V. Mayevskaya, M. Yu. Nadinskaia, V. D. Lunkov, I. Yu. Pirogova, E. V. Chesnokov, Kh. B. Kodzoeva, V. T. Ivashkin   +6 more
doaj   +1 more source

Severe drug-induced liver injury associated with prolonged use of Linezolid [PDF]

, 2010
This study aims to describe a patient developing concomitant severe liver failure and lactic acidosis after long-term treatment with linezolid. A 55-year-old Caucasian woman developed concomitant severe liver failure and lactic acidosis after a treatment
Benoit, Dominique, De Bus, Liesbet, Depuydt, Pieter, Libbrecht, Louis, NOLLET, JOKE, Van Vlierberghe, Hans, Vandekerckhove, Linos, Vogelaers, Dirk   +7 more
core   +1 more source

The role of lipid and lipoprotein metabolism in non-alcoholic fatty liver disease [PDF]

, 2017
Due to the epidemic of obesity across the world, nonalcoholic fatty liver disease (NAFLD) has become one of the most prevalent chronic liver disorders in children and adolescents.
Anania, Caterina, Lavorato, Michela, Perla, Francesco Massimo, Prelati, Maurizia, Visicchio, Daniele   +4 more
core   +2 more sources

The Emerging Role of Disturbed CoQ Metabolism in Nonalcoholic Fatty Liver Disease Development and Progression [PDF]

, 2015
Although non-alcoholic fatty liver disease (NAFLD), characterised by the accumulation of triacylglycerol in the liver, is the most common liver disorder, the causes of its development and progression to the more serious non-alcoholic steatohepatitis ...
Elena Bravo, Kathleen Botham, Mariarosaria Napolitano, Sumimoto   +3 more
core   +3 more sources

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor. [PDF]

, 2016
Background and objectivesObesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity.
Bakirtzi, K, Cheng, M, Fisseha, E, Fleshner, P, Gallo, RL, Hing, TC, Ho, S, Hoang-Ngoc Tran, D, Hoang-Yen Tran, D, Karagiannides, I, Koon, HW, Law, I, Lee, EC, Lee, JE, Li, Z, Mattai, SA, McGovern, DPB, Ortiz, C, Robbins, L, Sallam, T, Shieh, C, Shih, DQ, Sideri, A, Su, B, Targan, SR, Vu, M   +25 more
core   +1 more source