Results 31 to 40 of about 116,875 (269)

A Modular Liver–Microbial Microfluidic Platform to Evaluate Therapeutic and Adverse Effects of Microbial Metabolites

Advanced Healthcare Materials, EarlyView.
This study introduces a modular microfluidic platform that connects liver cells with live microbes to mimic key aspects of the gut–liver interaction in steatosis. Using this system, both microbial metabolites and live bacteria significantly reduced fat accumulation in liver cells, but live microbes triggered inflammation and broader metabolic changes ...
Hsih‐Yin Tan, In Young Hwang, Nanthini Jayabalan, Hui Ling Lee, Louis Jun Ye Ong, Chwee Teck Lim, Matthew Wook Chang, Yi‐Chin Toh   +7 more
wiley   +1 more source

The Root Extract of Rosa multiflora Ameliorates Nonalcoholic Steatohepatitis Development via Blockade of De Novo Lipogenesis and Inflammation

Current Issues in Molecular Biology
Nonalcoholic steatohepatitis (NASH) is characterized by severe inflammation and fibrosis due to an excessive accumulation of triglycerides (TGs) in the liver with a dysregulated de novo lipogenesis (DNL) pathway.
Nam-Hee Kim, Seung-Jin Lee, Kyeong-Jin Lee, Ae Ri Song, Hyun-Je Park, Jong Soo Kang, Joo Young Cha, Yong-Hyun Han   +7 more
doaj   +1 more source

Benefits of Physical Exercise as Approach to Prevention and Reversion of Non-Alcoholic Fatty Liver Disease in Children and Adolescents with Obesity

Children, 2022
Non-alcoholic fatty liver disease (NAFLD) is an important health concern during childhood; indeed, it is the most frequent cause of chronic liver diseases in obese children.
Valeria Calcaterra, Vittoria Carlotta Magenes, Matteo Vandoni, Clarissa Berardo, Luca Marin, Alice Bianchi, Erika Cordaro, Giustino Simone Silvestro, Dario Silvestri, Vittoria Carnevale Pellino, Cristina Cereda, Gianvincenzo Zuccotti   +11 more
doaj   +1 more source

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Imaging and immunometabolic phenotyping uncover changes in the hepatic immune response in the early phases of NAFLD

JHEP Reports, 2020
Background & Aims: The precise determination of non-alcoholic fatty liver disease (NAFLD) onset is challenging. Thus, the initial hepatic responses to fat accumulation, which may be fundamental to our understanding of NAFLD evolution and clinical ...
Ariane Barros Diniz, Maísa Mota Antunes, Viviane Aparecida de Souza Lacerda, Brenda Naemi Nakagaki, Maria Alice Freitas Lopes, Hortência Maciel de Castro-Oliveira, Matheus Silvério Mattos, Kassiana Mafra, Camila Dutra Moreira de Miranda, Karen Marques de Oliveira Costa, Mateus Eustáquio Lopes, Débora Moreira Alvarenga, Raquel Carvalho-Gontijo, Sarah Cozzer Marchesi, Debora Romualdo Lacerda, Alan Moreira de Araújo, Érika de Carvalho, Bruna Araújo David, Mônica Morais Santos, Cristiano Xavier Lima, Juliana Assis Silva Gomes, Tereza Cristina Minto Fontes Cal, Bruna Roque de Souza, Cláudia Alves Couto, Luciana Costa Faria, Paula Vieira Teixeira Vidigal, Adaliene Versiane Matos Ferreira, Sridhar Radhakrishnnan, Matthew Ricci, André Gustavo Oliveira, Rafael Machado Rezende, Gustavo Batista Menezes   +31 more
doaj   +1 more source

Exploring the Gamut of Receptor Tyrosine Kinases for Their Promise in the Management of Non-Alcoholic Fatty Liver Disease

Biomedicines, 2021
Recently, non-alcoholic fatty liver disease (NAFLD) has emerged as a predominant health concern affecting approximately a quarter of the world’s population.
Sayali Bhave, Han Kiat Ho
doaj   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Lipidomics for the Prediction of Progressive Liver Disease in Patients with Alcohol Use Disorder

Metabolites, 2022
Alcohol-related liver disease is a public health care burden globally. Only 10–20% of patients with alcohol use disorder have progressive liver disease.
Bei Gao, Suling Zeng, Luca Maccioni, Xiaochun Shi, Aaron Armando, Oswald Quehenberger, Xinlian Zhang, Peter Stärkel, Bernd Schnabl   +8 more
doaj   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source