Results 51 to 60 of about 197,639 (362)

Efficacy of pioglitazone in treatment of metabolic dysfunction-associated fatty liver disease

Al-Azhar Assiut Medical Journal
Background and aim Nonalcoholic fatty liver disease has emerged as a major public health challenge, with limited approved pharmacological therapies.
Mahmoud M. Khafagi, Hamdy M. Moustafa, Ahmed A. Ahmed, Mohamed A. Bashir, Abdelghany Aish, Amro M. Hassan   +5 more
doaj   +1 more source

Tri-Herbal Medicine Divya Sarva-Kalp-Kwath (Livogrit) Regulates Fatty Acid-Induced Steatosis in Human HepG2 Cells through Inhibition of Intracellular Triglycerides and Extracellular Glycerol Levels

Molecules, 2020
Steatosis is characterized by excessive triglycerides accumulation in liver cells. Recently, application of herbal formulations has gained importance in treating complex diseases.
Acharya Balkrishna, Vivek Gohel, Rani Singh, Monali Joshi, Yash Varshney, Jyotish Srivastava, Kunal Bhattacharya, Anurag Varshney   +7 more
doaj   +1 more source

Liver transplantation for alcoholic cirrhosis: Long term follow-up and impact of disease recurrence [PDF]

, 2001
Background. Alcoholic liver disease has emerged as a leading indication for hepatic transplantation, although it is a controversial use of resources. We aimed to examine all aspects of liver transplantation associated with alcohol abuse.
Andrea M. DiMartini, Anthony J. Demetris, Ashok Jain, Balan, Bassendine, Becker, Belle, Bellentani, Beresford, Beresford, Beresford, Berlakovich, Bernard, Bizollon, Blakolmer, Campbell, Chao, Christopher O.C. Bellamy, Conjeevaram, Cromie, Duvoux, Enomoto, Everhart, Everson, Fauerholdt, Ferrell, Forrest Dodson, Foster, Gane, Graziadei, Harrison, Hoofnagle, Howard, Iezzoni, Ishak, Jain, John J. Fung, Keeffe, Kenngott, Kris Ruppert, Kumar, Kyriacou, Lee, Levin, Levy, Lucey, Lucey, Lucey, Mendenhall, Michael Torbenson, Nabel, Neuberger, Neuberger, Neuberger, Osorio, Pageaux, Pappo, Pereira, Reed, Reich, Saunders, Schiff, Seitz, Sherlock, Shev, Starzl, Tang, Thomas E. Starzl, Tringali, Uchimura, Wiesner, Yates   +71 more
core   +2 more sources

Oxidative stress: new insights on the association of nonalcoholic fatty liver disease and atherosclerosis [PDF]

, 2015
Non-alcoholic fatty liver disease (NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to non-alcoholic steatohepatitis (NASH), which may progress ...
Albanese, Fabiana, Angelico, Francesco, Baratta, Francesco, DEL BEN, Maria, Pastori, Daniele, Perri, Ludovica, Polimeni, Licia, Violi, Francesco   +7 more
core   +1 more source

The impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes

Journal of Lipid Research, 2013
We showed earlier that nutritional stress like starvation or high-fat diet resulted in phenotypic changes in the lipidomes of hepatocyte lipid droplets (LDs), representative for the pathophysiological status of the mouse model.
Chandramohan Chitraju, Martin Trötzmüller, Jürgen Hartler, Heimo Wolinski, Gerhard G. Thallinger, Guenter Haemmerle, Rudolf Zechner, Robert Zimmermann, Harald C. Köfeler, Friedrich Spener   +9 more
doaj   +1 more source

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

Biomolecules, 2020
Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance. NAFLD involves a large spectrum of clinical conditions.
Clémence Rives, Anne Fougerat, Sandrine Ellero-Simatos, Nicolas Loiseau, Hervé Guillou, Laurence Gamet-Payrastre, Walter Wahli   +6 more
doaj   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Emerging Pathogenic Mechanisms and Therapeutic Implications

Livers
Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD), is the most common cause of chronic liver disease worldwide.
Farah Abdelhameed, Attia Mustafa, Chris Kite, Lukasz Lagojda, Alexander Dallaway, Nwe Ni Than, Eva Kassi, Ioannis Kyrou, Harpal S. Randeva   +8 more
doaj   +1 more source

Research on the Species Difference of the Hepatotoxicity of Medicine Based on Transcriptome

Frontiers in Pharmacology, 2021
In recent years, several drugs have been withdrawn from use by regulatory bodies owing to hepatotoxicity; therefore, studies on drug-induced liver injury (DILI) are being actively pursued. Most studies evaluating DILI use rats or mice as animal models to
Ziying Xu, Qianjun Kang, Zihui Yu, Zihui Yu, Zihui Yu, Lichun Tian, Jingxuan Zhang, Ting Wang   +7 more
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source