Results 51 to 60 of about 198,724 (360)

Comparative Transcriptome Analysis Reveals That Exendin-4 Improves Steatosis in HepG2 Cells by Modulating Signaling Pathways Related to Lipid Metabolism

Biomedicines, 2022
No therapy exists for non-alcoholic fatty liver disease (NAFLD). However, glucagon-like peptide receptor agonists (GLP-1RAs) showed a beneficial effect on NAFLD, although the underpinning mechanisms remain unclear due to their pleiotropic effects.
Khaoula Errafii, Olfa Khalifa, Neyla S. Al-Akl, Abdelilah Arredouani   +3 more
doaj   +1 more source

Oxidative stress: new insights on the association of nonalcoholic fatty liver disease and atherosclerosis [PDF]

, 2015
Non-alcoholic fatty liver disease (NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to non-alcoholic steatohepatitis (NASH), which may progress ...
Albanese, Fabiana, Angelico, Francesco, Baratta, Francesco, DEL BEN, Maria, Pastori, Daniele, Perri, Ludovica, Polimeni, Licia, Violi, Francesco   +7 more
core   +1 more source

Efficacy of pioglitazone in treatment of metabolic dysfunction-associated fatty liver disease

Al-Azhar Assiut Medical Journal
Background and aim Nonalcoholic fatty liver disease has emerged as a major public health challenge, with limited approved pharmacological therapies.
Mahmoud M. Khafagi, Hamdy M. Moustafa, Ahmed A. Ahmed, Mohamed A. Bashir, Abdelghany Aish, Amro M. Hassan   +5 more
doaj   +1 more source

Tri-Herbal Medicine Divya Sarva-Kalp-Kwath (Livogrit) Regulates Fatty Acid-Induced Steatosis in Human HepG2 Cells through Inhibition of Intracellular Triglycerides and Extracellular Glycerol Levels

Molecules, 2020
Steatosis is characterized by excessive triglycerides accumulation in liver cells. Recently, application of herbal formulations has gained importance in treating complex diseases.
Acharya Balkrishna, Vivek Gohel, Rani Singh, Monali Joshi, Yash Varshney, Jyotish Srivastava, Kunal Bhattacharya, Anurag Varshney   +7 more
doaj   +1 more source

Subclinical myocardial disease by cardiac magnetic resonance imaging and spectroscopy in healthy HIV/Hepatitis C virus-coinfected persons. [PDF]

, 2017
Objective The contribution of hepatitis C virus (HCV) infection to the risk of heart failure in human immunodeficiency virus (HIV)-coinfected persons is unknown.
Ambale-Venkatesh, Bharath, Bluemke, David A, Butt, Adeel A, Chew, Kara W, Currier, Judith S, Horwich, Tamara B, Liao, Diana, Lima, João AC, Liu, Chia-Ying, Paul Finn, J   +9 more
core   +2 more sources

Two-hour postload glycemia is associated to an increased risk of NAFLD in healthy subjects with family history of type 2 diabetes: a case control study [PDF]

, 2016
Nonalcoholic fatty liver disease (NAFLD) includes steatosis and nonalcoholic steatohepatitis (NASH), which can be complicated by cirrhosis and hepatocellular carcinoma [1].
CARNOVALE, ANNA, FILARDI, TIZIANA, LENZI, Andrea, MARIANI, Paola, MORANO, Susanna, Nieddu, Luciano, PALLOTTA, Nadia, VINCOLI, GIUSEPPINA   +7 more
core   +1 more source

The impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes

Journal of Lipid Research, 2013
We showed earlier that nutritional stress like starvation or high-fat diet resulted in phenotypic changes in the lipidomes of hepatocyte lipid droplets (LDs), representative for the pathophysiological status of the mouse model.
Chandramohan Chitraju, Martin Trötzmüller, Jürgen Hartler, Heimo Wolinski, Gerhard G. Thallinger, Guenter Haemmerle, Rudolf Zechner, Robert Zimmermann, Harald C. Köfeler, Friedrich Spener   +9 more
doaj   +1 more source

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

Biomolecules, 2020
Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance. NAFLD involves a large spectrum of clinical conditions.
Clémence Rives, Anne Fougerat, Sandrine Ellero-Simatos, Nicolas Loiseau, Hervé Guillou, Laurence Gamet-Payrastre, Walter Wahli   +6 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Emerging Pathogenic Mechanisms and Therapeutic Implications

Livers
Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction-associated steatotic liver disease (MASLD), is the most common cause of chronic liver disease worldwide.
Farah Abdelhameed, Attia Mustafa, Chris Kite, Lukasz Lagojda, Alexander Dallaway, Nwe Ni Than, Eva Kassi, Ioannis Kyrou, Harpal S. Randeva   +8 more
doaj   +1 more source