Results 41 to 50 of about 15,379,079 (345)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Design-related reassessment of structures integrating Bayesian updating of model safety factors

Results in Engineering, 2022
In the semi-probabilistic approach of structural design, the partial safety factors are defined by considering some degree of uncertainties to actions and resistance, associated with the parameters’ stochastic nature.
S. Chowdhury, M. Kraus
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Approach for redefining the damping factor of railway bridges with ballast superstructure: model calibration and guidelines for practical application

Railway Engineering Science
To ensure the compatibility between rolling stock and infrastructure when dynamically assessing railway bridges under high-speed traffic, the damping properties considered in the calculation model significantly influence the predicted acceleration ...
Andreas Stollwitzer, Samuel Loidl, Lara Bettinelli, Josef Fink   +3 more
doaj   +1 more source

Key Parameters and Form-Finding of an Innovative Prefabricated Steel Bridge

The Baltic Journal of Road and Bridge Engineering, 2015
Accelerated bridge construction is desired in urban areas or after natural disasters, thus, it has drawn the attention of the bridge community and transportation agencies worldwide.
Pei Chi, Zhebin Dai, Jun Dong
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Novel evaluation methods for data-based determination of damping factors in the frequency and time domains with application on railway bridges

Railway Engineering Science
A realistic and economical dynamic assessment of railway bridges requires input parameters that correspond to reality. In this context, the applied damping properties of the structure have a decisive influence on the results in the prediction of ...
Andreas Stollwitzer, Lara Bettinelli, Samuel Loidl, Janez Schellander, Michael Vospernig, Josef Fink   +5 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Case study report on design, manufacturing and digital representation of a DED-Arc steel node for construction

Scientific Reports
This report presents a comprehensive investigation into the design, manufacturing, and evaluation of a DED-Arc (also known as Wire Arc Additive Manufacturing, WAAM) Y-Node for the construction industry.
Johanna Müller, Hendrik Jahns, Marc Müggenburg, Klaus Thiele, Julian Unglaub, Jonas Hensel   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source